公开(公告)号：US20060119135A1

公开(公告)日：2006-06-08

申请号：US11272281

申请日：2005-11-10

Applicant: Kerry McClure ,  Yaniv Rock ,  Nick Massaro ,  David Edwards ,  Robb Augustine

Inventor： Kerry McClure ,  Yaniv Rock ,  Nick Massaro ,  David Edwards ,  Robb Augustine

IPC: B60J7/00

CPC classification number: B62D33/0273 ,  B62D25/087 ,  B62D33/02 ,  B62D43/10

Abstract: A vehicle frame includes a pair of spaced frame rails and at least one cross member connecting the frame rails. A tower structure is on one of the spaced frame rails for supporting a floor of a load-carrying bed spaced above the frame rails.

Abstract translation: 车架包括一对隔开的框架轨道和连接框架轨道的至少一个横向构件。 塔架结构位于隔开的框架轨道之一上，用于支撑在框架轨道上方间隔开的承载床的地板。

公开(公告)号：US07052672B2

公开(公告)日：2006-05-30

申请号：US10465974

申请日：2001-04-11

Applicant: Alan Michael Forster ,  David Edwards ,  Ole Kristian Hjelstuen

Inventor： Alan Michael Forster ,  David Edwards ,  Ole Kristian Hjelstuen

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K51/121

Abstract: The present invention relates to stabilized 99mTc radiopharmaceutical compositions, which include both a radioprotectant and one or more antimicrobial preservative(s), and hence have an extended lifetime of use. The radioprotectant is ascorbic acid, para-aminobenzoic acid, gentisic acid or a salt thereof with a biocompatible cation, and the antimicrobial preservative is one or more compound from the paraben series of preservatives. The invention is particularly useful for cationic, lipophilic 99mTc heart imaging agents such as Myoview™.

Abstract translation: 本发明涉及稳定的99m Tc放射性药物组合物，其包括放射防护剂和一种或多种抗微生物防腐剂，因此具有延长的使用寿命。 抗生素防腐剂是抗坏血酸，对氨基苯甲酸，龙胆酸或其与生物相容性阳离子的盐，抗微生物防腐剂是一种或多种来自对羟基苯甲酸酯系列防腐剂的化合物。 本发明对于阳离子亲脂99m Tc心脏显像剂如Myoview TM是特别有用的。

公开(公告)号：US20060090927A1

公开(公告)日：2006-05-04

申请号：US10904276

申请日：2004-11-02

Applicant: David Edwards ,  Ronald Hering ,  David Long ,  Jason Miller ,  Carl Peterson

Inventor： David Edwards ,  Ronald Hering ,  David Long ,  Jason Miller ,  Carl Peterson

IPC: H05K3/30

CPC classification number: H05K7/142

Abstract: A cam-action expanding standoff connector and related method are disclosed for mounting a circuit board. The standoff connector includes a body and a plurality of mounting members having interior longitudinally-extending camming portions for engagement by a cam. A cam is configured to be positioned within the mounting members in a first position in which the mounting members are not expanded against the interior of a mounting opening and in a second position in which the cam engages the camming portions to expand the plurality of mounting members against the interior of the mounting opening. Since the camming action is horizontal only (purely radial), practically no vertical forces are applied to the circuit board and a best-fit alignment between a circuit board and heatsink can be established and maintained.

Abstract translation: 公开了一种用于安装电路板的凸轮动作扩展型支座连接器及相关方法。 支座连接器包括主体和多个安装构件，其具有用于由凸轮接合的内部纵向延伸的凸轮部分。 凸轮构造成在安装构件内定位在第一位置，在第一位置，安装构件不会抵靠安装开口的内部膨胀，并且在第二位置中凸轮接合凸轮部分以使多个安装构件 抵靠安装开口的内部。 由于凸轮作用仅仅是水平的（纯径向的），实际上没有垂直力施加到电路板上，并且可以建立和维持电路板和散热器之间的最佳配合。

公开(公告)号：USD514998S1

公开(公告)日：2006-02-14

申请号：US29190108

申请日：2003-09-16

Applicant: Jarad W. Hall ,  Donald Lariviere ,  David Edwards

Designer： Jarad W. Hall ,  Donald Lariviere ,  David Edwards

公开(公告)号：US20050244341A1

公开(公告)日：2005-11-03

申请号：US11177719

申请日：2005-07-08

Applicant: David Edwards ,  Giovannia Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdell Ben-Jebria ,  Robert Langer

Inventor： David Edwards ,  Giovannia Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdell Ben-Jebria ,  Robert Langer

IPC: A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/57 ,  A61K38/28 ,  A61K47/34 ,  A61L9/04 ,  G06F7/00 ,  G06F17/30

CPC classification number: A61K31/57 ,  A61K9/0075 ,  A61K9/1647 ,  A61K9/1682 ,  A61K38/28 ,  A61K47/34 ,  G06F16/284

Abstract: Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.

Abstract translation: 提供用于递送至肺系统的改善的空气动力学轻微颗粒，以及其制备和给药方法。 在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚（氨基酸）侧链上的直链α-羟基酸聚酯主链组成 集团在聚酯骨干。 在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。 空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂，并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。

公开(公告)号：US20050220720A1

公开(公告)日：2005-10-06

申请号：US10513165

申请日：2003-05-01

Applicant: David Edwards ,  Howard Stone

Inventor： David Edwards ,  Howard Stone

IPC: A61K9/00 ,  A61K9/14 ,  A61L9/04 ,  A61M11/00

CPC classification number: A61K9/0078 ,  A61K9/0075 ,  A61K9/008

Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

Abstract translation: 已经开发了用于肺部输送以治疗或减少诸如病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。

公开(公告)号：US20050207758A1

公开(公告)日：2005-09-22

申请号：US11130192

申请日：2005-05-17

Applicant: David Edwards ,  Dominic O'Brien ,  Grahame Faulkner ,  David Holburn ,  Robert Mears

Inventor： David Edwards ,  Dominic O'Brien ,  Grahame Faulkner ,  David Holburn ,  Robert Mears

IPC: H01L31/12 ,  H04B10/114 ,  H04B10/00

CPC classification number: H04B10/114 ,  H04B10/1149

Abstract: An optical wireless local area network using line of sight optical links. The base station and terminal stations are provided with optical transceivers which include a transmitter array and detector array. The transmitter array consists of an array of resonant cavity light emitting diodes integrated using flip-chip technology with a CMOS driver circuit. The driver circuit includes constant bias, current peaking and charge extraction. The driver circuitry is compact and can be confined within a region underlying the corresponding light source. The detector array consists of an array of photo diodes, provided with sense circuitry consisting of a pre-amplifier and post-amplifier. The diodes and sense circuitry are also integrated using a flip-chip technique. The light emitter and the detector may include adaptive optical elements to steer and/or focus the light beams.

Abstract translation: 一种使用视线光链路的光无线局域网。 基站和终端设置有光收发器，其包括发射机阵列和检测器阵列。 发射器阵列由使用倒装芯片技术与CMOS驱动器电路集成的谐振腔发光二极管阵列组成。 驱动电路包括恒定偏置，电流峰化和电荷抽取。 驱动器电路紧凑，并且可以限制在相应光源下面的区域内。 检测器阵列由一组光电二极管组成，具有由前置放大器和后置放大器组成的感测电路。 二极管和感测电路也使用倒装芯片技术集成。 光发射器和检测器可以包括用于引导和/或聚焦光束的自适应光学元件。

公开(公告)号：US20050182746A1

公开(公告)日：2005-08-18

申请号：US10997687

申请日：2004-11-24

Applicant: Steven Potts ,  Sandor Szalma ,  Yin Yu ,  Scott Kahn ,  David Edwards

Inventor： Steven Potts ,  Sandor Szalma ,  Yin Yu ,  Scott Kahn ,  David Edwards

IPC: G06F7/00 ,  G06F17/30 ,  G06F19/16 ,  G06F19/28

CPC classification number: G16B50/00 ,  G16B15/00

Abstract: Systems and methods for storing protein structure information are provided. The system comprises a non-public database storing protein structure information, wherein the non-public database is coupled to a public database of non-proprietary protein structure information and to non-public sources of proprietary protein structure information. The non-public database may also be coupled to a database having protein structure information for substantially all the proteins of at least one organism genome. The method may comprise loading protein structure data from at least one public database and loading protein structure data from one or more proprietary sources of protein structure information. The public database may comprise the Protein Data Bank (PDB). Certain types of additional information are also advantageously loaded into the database. These may include classification data corresponding to at least one protein ontology. Mass spectroscopy data, NMR data and x-ray crystallography data may also be loaded into the database.

Abstract translation: 提供了存储蛋白质结构信息的系统和方法。 该系统包括存储蛋白质结构信息的非公开数据库，其中非公开数据库耦合到非专有蛋白质结构信息的公共数据库以及专有蛋白质结构信息的非公有源。 非公开数据库还可以耦合到具有至少一个生物基因组的基本上所有蛋白质的蛋白质结构信息的数据库。 该方法可以包括从至少一个公共数据库加载蛋白质结构数据并从蛋白质结构信息的一个或多个专有来源加载蛋白质结构数据。 公共数据库可以包括蛋白质数据库（PDB）。 某些类型的附加信息也有利地被加载到数据库中。 这些可以包括对应于至少一个蛋白质本体的分类数据。 质谱数据，NMR数据和X射线晶体学数据也可以加载到数据库中。

公开(公告)号：US20050057074A1

公开(公告)日：2005-03-17

申请号：US10663269

申请日：2003-09-16

Applicant: Robb Augustine ,  David Edwards

Inventor： Robb Augustine ,  David Edwards

IPC: B62D25/20 ,  B62D33/023 ,  B62D33/02

CPC classification number: B62D33/023 ,  B62D25/2054 ,  B62D25/2072

Abstract: A bed system for a pickup truck includes a first member adapted for securement to a first support component associated with a truck bed. The first member has a first surface for contacting cargo and a first edge portion extending at least partially along the periphery of the first member. A second member is adapted for securement to a second support component associated with a truck bed. The second member has a second surface for contacting cargo and has a second edge portion extending at least partially along the periphery of the second member. At least a portion of the second edge portion is oriented in at least a partially overlapping spaced relationship to at least a portion of the first edge portion at an interface. A cushioning element is located between the overlapping first and second edge portions at the interface. The cushioning element is resiliently compressible and permits relative movement between the first and second edge portions at the interface.

Abstract translation: 用于皮卡车的床系统包括适于固定到与卡车床相关联的第一支撑部件的第一部件。 第一构件具有用于接触货物的第一表面和至少部分地沿着第一构件的周边延伸的第一边缘部分。 第二构件适于固定到与卡车床相关联的第二支撑构件。 第二构件具有用于接触货物的第二表面，并且具有至少部分地沿着第二构件的周边延伸的第二边缘部分。 第二边缘部分的至少一部分在界面处至少部分地与第一边缘部分的部分重叠的间隔关系定向。 缓冲元件位于界面处的重叠的第一和第二边缘部分之间。 缓冲元件是可弹性压缩的并且允许在界面处的第一和第二边缘部分之间的相对移动。

公开(公告)号：US20050057060A1

公开(公告)日：2005-03-17

申请号：US10663273

申请日：2003-09-16

Applicant: David Edwards ,  Robb Augustine ,  Kerry McClure ,  James Ryan ,  Dennis Chung

Inventor： David Edwards ,  Robb Augustine ,  Kerry McClure ,  James Ryan ,  Dennis Chung

IPC: B60P7/08 ,  B62D25/08 ,  B62D27/06 ,  B62D29/04 ,  B62D43/10 ,  B62D25/00

CPC classification number: B62D29/048 ,  B60P7/0807 ,  B62D25/087 ,  B62D27/065 ,  B62D43/10

Abstract: Exemplary embodiments disclose a fastening system with an object including a securement structure with an extension element adapted to be compressed by a fastener. A portion of the securement structure extends above a first end of a compression reinforcement device. The extension element is adapted to be compressed by a fastener such that the portion of the securement structure is positioned substantially level with the first end and wherein the compression reinforcement device and the securement structure both receive compressive force from a fastener.

Abstract translation: 示例性实施例公开了具有物体的紧固系统，该物体包括具有适于被紧固件压缩的延伸元件的固定结构。 固定结构的一部分延伸到压缩加强装置的第一端之上。 延伸元件适于被紧固件压缩，使得固定结构的部分与第一端大致平齐，并且其中压缩加强装置和固定结构均接收来自紧固件的压缩力。