Patent search ap:("GILEAD SCIENCES Page INC.") AND inv:"Scott E. Lazerwith"

101.

发明申请
SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS 审中-公开
Title translation: 多环碳酰亚胺基化合物的合成

公开(公告)号：US20150368264A1

公开(公告)日：2015-12-24

申请号：US14740954

申请日：2015-06-16

Applicant: Gilead Sciences, Inc.

Inventor： Anna Chiu , John Enquist, JR. , Nolan Griggs , Christopher Hale , Norihiro Ikemoto , Katie Ann Keaton , Matt Kraft , Scott E. Lazerwith , Michel Leeman , Zhihui Peng , Kate Schrier , Jonathan Trinidad , Jochem Van Herpt , Andrew W. Waltman

IPC: C07D498/14 , C07D309/40 , C07C237/20 , C07D213/82 , C07D319/06 , C07C235/78

Abstract: Methods of making compounds of Formula I are disclosed:

Abstract translation: 公开了制备式I化合物的方法：

102.

发明授权
Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepines and methods for treating viral infections 有权
Title translation: 取代的2,3,4,5,7,9,13,13a-八氢吡啶并[1'，2'：4,5]吡嗪并[2,1-b] [1,3]氧氮杂和治疗病毒感染的方法

公开(公告)号：US09216996B2

公开(公告)日：2015-12-22

申请号：US14133858

申请日：2013-12-19

Applicant: Gilead Sciences, Inc.

Inventor： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun

IPC: A61K31/4985 , C07D241/38 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18

CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

103.

发明申请
SYK INHIBITORS 有权
Title translation: SYK抑制剂

公开(公告)号：US20150038488A1

公开(公告)日：2015-02-05

申请号：US14448160

申请日：2014-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Kevin S. Currie , Zhimin Du , Julie Farand , Juan A. Guerrero , Ashley A. Katana , Darryl Kato , Scott E. Lazerwith , Jiayao Li , John O. Link , Nicholas Mai , Gregory Notte , Hyung-Jung Pyun , Michael Sangi , Aaron C. Schmitt , Adam J. Schrier , Kirk L. Stevens , Chandrasekar Venkataramani , William J. Watkins , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel

IPC: C07D487/04 , C07D417/04 , C07D417/12 , C07D403/12 , C07D471/04 , C07D401/14

CPC classification number: C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/08 , C07D498/04 , C07D519/00

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract translation: 本公开涉及作为Syk抑制剂的化合物及其在治疗各种疾病状态（包括癌症和炎性病症）中的用途。在具体实施方案中，化合物的结构由式I给出，其中X 1，X 2，X 3，R 2，R 3，R 4，R 5和Y如本文所述。本公开进一步提供包含式I化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物和组合物治疗由Syk介导的病症的方法。

104.

发明授权
Inhibitors of Flaviviridae viruses 有权
Title translation: 黄病毒科病毒的抑制剂

公开(公告)号：US08884030B2

公开(公告)日：2014-11-11

申请号：US13958424

申请日：2013-08-02

Applicant: Gilead Sciences, Inc.

Inventor： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Michael Mertzman , Philip A. Morganelli , William J. Watkins

IPC: C07D409/00 , A61K31/497 , A61K31/427 , C07D493/04 , A61K31/4545 , A61K45/06 , C07D409/14 , A61K31/4535 , A61K31/454 , A61K31/4025 , C07D413/12 , C07D333/38 , A61K31/501 , A61K31/381 , C07D409/12

CPC classification number: C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Abstract translation: 提供式I化合物及其药学上可接受的盐和酯。所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。