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公开(公告)号：US20230017342A1
公开(公告)日：2023-01-19
申请号：US17954553
申请日：2022-09-28
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Daixi XIN
Abstract: The present disclosure is drawn to microfluidic cellular membrane modification. In one example, a method of modifying cells can include pumping a fluid comprising cells in a forward direction through a microfluidic channel, applying an electric field within the microfluidic channel as cells flow in the forward direction through the electric field and beyond within the microfluidic channel, and pumping the fluid in a backward direction through the microfluidic channel, wherein cells flow in the backward direction returning through the electric field.
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公开(公告)号：US20230008110A1
公开(公告)日：2023-01-12
申请号：US17778957
申请日：2020-04-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Alexander N. Govyadinov
Abstract: An integrated fluid ejection and spectroscopic sensing system may include a fluid ejector to eject a droplet of fluid through an ejection orifice towards a deposition site, a sensor array, a dispersive element to project light onto the sensor array. The dispersive element, the sensor and the fluid ejector are joined as part of an integrated unit.
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公开(公告)号：US20220414894A1
公开(公告)日：2022-12-29
申请号：US17778574
申请日：2019-12-12
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Yang Lei , Viktor Shkolnikov
IPC: G06T7/20
Abstract: In example implementations, an apparatus is provided. The apparatus includes a channel, a camera, and a processor. The channel contains a fluid and an object. The fluid is to move the object through the channel. The camera system is to capture video images of the object in the channel. The processor is to track movement of the object in the channel via the video images based on known flow dynamics of the channel.
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公开(公告)号：US11485944B2
公开(公告)日：2022-11-01
申请号：US16606841
申请日：2018-04-04
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Daixi Xin
Abstract: The present disclosure is drawn to microfluidic cellular membrane modification devices. In one example, a microfluidic cellular membrane modification device can include a microfluidic channel including a pumping portion and an electric field portion. An electrode pair can be positioned about the electric field portion. A bidirectional pump can be in fluid communication with the microfluidic channel at the pumping portion to move fluid backward and forward through the electric field portion.
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公开(公告)号：US11478793B2
公开(公告)日：2022-10-25
申请号：US16605619
申请日：2017-10-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Chien-Hua Chen , Michael W Cumbie
Abstract: In an example implementation, a microfluidic device includes a first layer with a first microfluidic channel and a second layer with a second microfluidic channel. The first and second channels are adjacent to one another at a channel intersection, and a conductive membrane valve extends across and covers the channel intersection to separate the first and second channels. The microfluidic device includes a conductive trace to open the membrane valve and join the first and second channels by supplying an electric current to heat and melt a thinned region of the membrane valve.
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Patent Agency Ranking
公开(公告)号：US20220280942A1
公开(公告)日：2022-09-08
申请号：US17752394
申请日：2022-05-24
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Anita ROGACS
Abstract: An apparatus of an enzymatic sample purifier can include a reaction chamber containing a polypeptide synthesizing enzyme capable of reacting with a protein degradation product to form polypeptides having a size of at least 1,000 Da and including the protein degradation product, the reaction chamber having a port configured to receive a fluid sample including a target analyte having a size of no greater than 500 Da and the protein degradation product. The apparatus can also include a product chamber, an electrophoretic transport mechanism to move a purified portion of the fluid sample including the target analyte to the product chamber, and a separator positioned to retain the formed polypeptides resulting from reaction of the protein degradation product with the polypeptide synthesizing enzyme in the reaction chamber and to pass the target analyte to the product chamber, wherein the separator comprises a porous matrix.
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公开(公告)号：US20220250070A1
公开(公告)日：2022-08-11
申请号：US17415213
申请日：2019-09-14
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Chien-Hua Chen , Daixi Xin
Abstract: A fluid entrained particle separation system may include a particle separator, a main fluid passage extending along an axis to guide translational fluid flow along the axis to the particle separator and a side fluid inlet connected to the main fluid passage to generate a vortex about the axis. The vortex concentrates less dense material in the fluid flow towards the axis.
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公开(公告)号：US11364503B2
公开(公告)日：2022-06-21
申请号：US16077362
申请日：2017-07-17
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Kenneth Ward
Abstract: A microfluidic device may, in an example, include at least one microfluidic channel, a dielectrophoresis separator to separate a plurality of cells passing within the at least one microfluidic channel, and a thermal resistor to eject at least one cell from the microfluidic device. A cassette may, in an example, include a die coupled to a substrate of the cassette, the die including at least one microfluidic channel, a dielectrophoresis separator along the microfluidic channel to separate a plurality of cells passing within the microfluidic channel, and an ejection device to eject at least one of the plurality of cells into an assay well.
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公开(公告)号：US20220145331A1
公开(公告)日：2022-05-12
申请号：US17429962
申请日：2019-06-24
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: Examples disclosed herein relate to single cell transfection with interchangeable reagent. The present disclosure relates generally to a device, method, and system for single cell transfection including a transfection chamber on a transfection chip. The example system may include a fluidic channel located on the transfection chip for guiding a cell towards the transfection chamber, the fluidic channel sized to allow no more than a single cell to arrive at the transfection chamber at a time. The example system may also include a reagent receiver located on the transfection chip guiding received reagent towards the transfection chamber and intersecting with the path of the fluidic channel.
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公开(公告)号：US20220072549A1
公开(公告)日：2022-03-10
申请号：US17417280
申请日：2019-04-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Viktor Shkolnikov , Alexander Govyadinov
Abstract: The present disclosure relates to a microfluidic concentrating particlizers including a particle generator, a particle concentrator, and a fluid movement network. The particle generator includes a sample inlet microchannel and a reagent inlet microchannel. The sample inlet microchannel is operable to direct a source sample. The reagent inlet microchannel is operable to direct reagent. The source sample and reagent come in contact to form a sample fluid dispersion including sample-modified particulates and fluid. The particle concentrator includes a filtering chamber fluidly coupled to the particle generator to concentrate sample-modified particulates relative to the fluid. The fluid movement network includes multiple pumps to generate fluidic flow through both the particle generator and the particle concentrator.
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