-
公开(公告)号：US08415377B2
公开(公告)日：2013-04-09
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/14 , C07D403/04 , A61K31/4196 , A61K31/4709
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
-
公开(公告)号：US20110105483A1
公开(公告)日：2011-05-05
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
IPC分类号： A61K31/4196 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P37/00 , A61P31/10 , A61P7/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperprolif erative disorders, such as cancer, in a subject in need thereof.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的多药耐药性疾病如癌症的药物中的用途。
-
公开(公告)号：US08053456B2
公开(公告)日：2011-11-08
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
-
公开(公告)号：US20080176840A1
公开(公告)日：2008-07-24
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D401/14 , A61K31/4439 , C07D471/04 , A61K31/538 , A61K31/496 , A61P37/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61K31/5377 , C07D413/14 , A61K31/52 , A61K31/4709 , C07D403/02
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
-
公开(公告)号：US20110319447A1
公开(公告)日：2011-12-29
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4709 , C07D413/14 , A61P35/00 , A61K31/4196 , A61K31/422 , C07D403/12 , C07D403/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
-
公开(公告)号：US20070249661A1
公开(公告)日：2007-10-25
申请号：US11233224
申请日：2005-09-21
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
IPC分类号： A61K31/44 , A61K31/40 , A61K31/415 , A61P19/02 , A61P5/00 , C07D235/28 , C07D471/02 , C07D455/02 , C07D235/00 , A61P3/10 , A61P17/00 , A61K31/437
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
-
公开(公告)号：US07709518B2
公开(公告)日：2010-05-04
申请号：US11233224
申请日：2005-09-21
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
IPC分类号： A61K31/415 , A01N43/52 , C07D235/00 , C07D235/18
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
-
公开(公告)号：US08314134B2
公开(公告)日：2012-11-20
申请号：US12718366
申请日：2010-03-05
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
IPC分类号： C07D235/00 , A01N43/52 , A61K31/415
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
-
公开(公告)号：US20100311787A1
公开(公告)日：2010-12-09
申请号：US12718366
申请日：2010-03-05
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
IPC分类号： A61K31/437 , A61K31/4184 , A61K31/4439 , A61K31/433 , A61P37/00 , A61P35/00 , A61P17/06 , A61P1/04 , A61P3/10 , A61P19/02 , A61P11/00 , A61P25/28 , C12N5/0783
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
-
公开(公告)号：US20130142831A1
公开(公告)日：2013-06-06
申请号：US13652878
申请日：2012-10-16
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
IPC分类号： A61K31/437
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
-
-
-
-
-
-
-
-
-
搜索结果
194 条记录 (耗时 0.05 秒)
