公开(公告)号：US20100249876A1

公开(公告)日：2010-09-30

申请号：US12815084

申请日：2010-06-14

申请人： Jonathon E. Giftakis ,  Martin T. Gerber

发明人： Jonathon E. Giftakis ,  Martin T. Gerber

IPC分类号： A61N1/34

CPC分类号： A61K31/485 ,  A61K31/7076 ,  A61K38/31 ,  A61M5/14276 ,  A61M5/172 ,  A61M2005/1405 ,  A61M2205/054 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/1021 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/37288

摘要： The disclosure describes a method and system for applying electrical stimulation to an iliohypogastric nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both iliohypogastric nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to an anterior cutaneous branch of one or both iliohypogastric nerves, a lateral cutaneous branch of one or both iliohypogastric nerves, or one or both of iliohypogastric nerves above the branch point.

摘要翻译： 本公开描述了一种对患者的髂腹下神经施加电刺激的方法和系统。 该系统包括电刺激器，其应用电刺激以缓解盆腔疼痛。 该系统可以对男性或女性进行电刺激用于骨盆疼痛。 电刺激器可以包括各种类型的电极，例如袖带电极，电极引线和微刺激器，其植入在靠近患者的单个或两个髂腹下神经的各个位置处。 特别地，电极可以被植入邻近或邻近髂腹下神经的一个或两个的前皮肤分支，一个或两个髂腹下神经的外侧皮肤分支，或在分支点之上的髂腹下神经中的一个或两个。

公开(公告)号：US20100240949A1

公开(公告)日：2010-09-23

申请号：US12795336

申请日：2010-06-07

申请人： Martin T. Gerber

发明人： Martin T. Gerber

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61B5/204 ,  A61B5/686

摘要： The disclosure describes a sensing device that is implantable to sense bladder conditions, as well as a neurostimulation system and method that make use of such a sensor for alleviation of urinary incontinence. The sensing device is implantable outside the bladder, but includes a lead that penetrates the bladder wall to deployed a sensor within the bladder. Using the sensor on the lead, the sensing device outside the bladder is able to detect a condition within the interior of the bladder. In this sense, the sensing device provides transmembrane sensing of internal bladder conditions. The condition may be indicative of bladder filling or bladder contraction, and may be used to control electrical stimulation applied to the patient to alleviate urinary incontinence.

摘要翻译： 本公开描述了可植入以感测膀胱状况的感测装置，以及利用这种传感器来减轻尿失禁的神经刺激系统和方法。 感测装置可植入膀胱外部，但包括穿过膀胱壁以在囊内部署传感器的引线。 使用导线上的传感器，膀胱外部的感测装置能够检测膀胱内部的状况。 在这个意义上，感测装置提供内部膀胱条件的跨膜感测。 该病症可以指示膀胱充盈或膀胱收缩，并且可以用于控制施加到患者的电刺激以减轻尿失禁。

公开(公告)号：US07761166B2

公开(公告)日：2010-07-20

申请号：US11414614

申请日：2006-04-28

申请人： Jonathan E. Giftakis ,  Martin T. Gerber

发明人： Jonathan E. Giftakis ,  Martin T. Gerber

IPC分类号： A61N1/36

CPC分类号： A61K31/485 ,  A61K31/7076 ,  A61K38/31 ,  A61M5/14276 ,  A61M5/172 ,  A61M2005/1405 ,  A61M2205/054 ,  A61M2205/3523 ,  A61M2205/50 ,  A61M2210/1021 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/37288

摘要： A method and system for applying electrical stimulation to an iliohypogastric nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both iliohypogastric nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to an anterior cutaneous branch of one or both iliohypogastric nerves, a lateral cutaneous branch of one or both iliohypogastric nerves, or one or both of iliohypogastric nerves above the branch point.

摘要翻译： 一种将电刺激施加到患者的髂腹下神经的方法和系统。 该系统包括电刺激器，其应用电刺激以缓解盆腔疼痛。 该系统可以对男性或女性进行电刺激用于骨盆疼痛。 电刺激器可以包括各种类型的电极，例如袖带电极，电极引线和微刺激器，其植入在靠近患者的单个或两个髂腹下神经的各个位置处。 特别地，电极可以被植入邻近或邻近髂腹下神经的一个或两个的前皮肤分支，一个或两个髂腹下神经的外侧皮肤分支，或在分支点之上的髂腹下神经中的一个或两个。

公开(公告)号：US20100030297A1

公开(公告)日：2010-02-04

申请号：US12576881

申请日：2009-10-09

申请人： Martin T. Gerber ,  Keith A. Miesel ,  Steven J. Shumaker

发明人： Martin T. Gerber ,  Keith A. Miesel ,  Steven J. Shumaker

IPC分类号： A61N1/05

CPC分类号： A61B5/202 ,  A61B5/205 ,  A61N1/36007

摘要： The disclosure describes an optical fiber pressure sensor to measure sphincter pressure which may be incorporated into a therapeutic sphincter control system. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of an optical fiber connected to flexible tube section placed through the sphincter, where properties of the emitted light are changed proportional to the pressure on the tube section. The light is returned to a light detector to measure light properties and create an electrical signal representative of the pressure on the tube section. The signal may then be sent by wireless telemetry to an implanted stimulator or external programmer.

摘要翻译： 本公开描述了一种用于测量括约肌压力的光纤压力传感器，该压力传感器可并入治疗括约肌控制系统中。 该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。 通过使用连接到通过括约肌放置的柔性管部分的光纤来实现测量括约肌压力，其中发射的光的性质与管部分上的压力成比例地变化。 光返回到光检测器以测量光性质并产生代表管部分上的压力的电信号。 然后可以通过无线遥测将信号发送到植入的刺激器或外部编程器。

公开(公告)号：US07611483B2

公开(公告)日：2009-11-03

申请号：US11737180

申请日：2007-04-19

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61M31/00

CPC分类号： A61B5/01 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/6846 ,  A61M5/14276 ,  A61M5/16836 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61N1/08 ,  A61N1/36521 ,  A61N1/37258 ,  A61N1/3756

摘要： A method for monitoring an infection in proximity to an implantable medical device includes monitoring an indicator of infection in proximity to an implanted medical device; determining whether the indicator crosses a first threshold indicative of infection for a first period of time; and issuing a first alert if the indicator crosses the first threshold for the first period of time. The method further includes determining whether the indicator crosses a second threshold indicative of infection for a second period of time. A value associated with the second threshold is less indicative of an infection than a comparable value associated with the first threshold. The second period of time is greater than the first period of time. The method further includes issuing a second alert if the indicator crosses the second threshold for the second period of time. The first and second alert may be the same or different.

摘要翻译： 用于监测靠近可植入医疗装置的感染的方法包括监测植入医疗装置附近的感染指示器; 确定所述指示符是否跨越指示第一时间段的感染的第一阈值; 以及如果所述指示符在所述第一时间段内跨过所述第一阈值，则发出第一​​警报。 该方法还包括确定指示符是否穿过指示第二时间段的感染的第二阈值。 与第二阈值相关联的值比与第一阈值相关联的可比值更少表示感染。 第二段时间大于第一时间段。 所述方法还包括：如果所述指示符在所述第二时间段内跨越所述第二阈值，则发出第二警报。 第一和第二警报可以相同或不同。

公开(公告)号：US07522061B2

公开(公告)日：2009-04-21

申请号：US11414626

申请日：2006-04-28

申请人： John C. Rondoni ,  Martin T. Gerber

发明人： John C. Rondoni ,  Martin T. Gerber

IPC分类号： G08B23/00

CPC分类号： A61B5/202 ,  A61B5/0002 ,  A61B5/14507 ,  A61B5/208 ,  A61B5/6804 ,  A61F13/42 ,  A61N1/36007 ,  G06F19/00

摘要： The disclosure describes an external sensor attached to an undergarment worn by a patient that detects voiding information. The sensor stores the voiding information in a voiding log and transmits the voiding log to an external device. The external device includes a user interface that displays the voiding log to the patient for review. The patient may correct any incorrect voiding information that was logged in error or due to a non-voiding event. A user, such as a clinician or the patient, may use the voiding information to diagnose a condition of the patient. In addition, the voiding information of the voiding log may be used by the user to adjust a stimulation therapy or the external device to automatically adjust stimulation therapy. The undergarment may be disposable or washable after patient use.

摘要翻译： 本公开描述了附接到由患者佩戴的检查排泄信息的内衣的外部传感器。 传感器将排泄信息存储在排空日志中，并将排气日志传送到外部设备。 外部设备包括用户界面，其向病人显示排尿日志以进行审查。 患者可能会纠正任何不正确的排泄信息，这些信息被记录错误或由于无排泄事件。 用户，例如临床医生或患者，可以使用排尿信息来诊断患者的状况。 此外，使用者可以使用排尿日志的排泄信息来调整刺激疗法或外部装置以自动调节刺激疗法。 使用后，内衣可以是一次性的或可洗涤的。

公开(公告)号：US20080300470A1

公开(公告)日：2008-12-04

申请号：US11755553

申请日：2007-05-30

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61B5/00

CPC分类号： A61B5/1116 ,  A61B5/02055 ,  A61B5/02438 ,  A61B5/0488 ,  A61B5/0816 ,  A61B5/091 ,  A61B5/202 ,  A61B5/6823 ,  A61B5/6825 ,  A61B5/686 ,  A61B2562/0219 ,  G06F19/00

摘要： Systems and methods for determining whether an involuntary voiding event was attributable to stress or urge incontinence include determining an activity level of a patient that coincides with the occurrence of the involuntary voiding event or the activity level within a certain time range of the involuntary voiding event. Patient activity data may be collected via a signal that varies as a function of patient activity. The signal may be generated with one or more sensors that detect motion, such as an accelerometer or a piezoelectric crystal, and/or one or more sensors that monitor a physiological parameter of the patient that varies as a function of patient activity, such as heart rate, respiratory rate, electrocardiogram morphology, respiration rate, respiratory volume, core temperature, muscular activity level or subcutaneous temperature of the patient.

摘要翻译： 用于确定非自愿排尿事件是否归因于压力或急迫性尿失禁的系统和方法包括确定与非自愿排尿事件的发生或非自愿排尿事件的特定时间范围内的活动水平一致的患者的活动水平。 患者活动数据可以通过根据患者活动而变化的信号来收集。 可以用一个或多个检测运动的传感器（例如加速度计或压电晶体）和/或监测根据患者活动而变化的患者的生理参数的一个或多个传感器来生成信号，例如心脏 速率，呼吸频率，心电图形态，呼吸频率，呼吸体积，核心温度，肌肉活动水平或皮下温度。

公开(公告)号：US20080281376A1

公开(公告)日：2008-11-13

申请号：US11800654

申请日：2007-05-07

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61N1/00

CPC分类号： A61N1/36003 ,  A61N1/36082 ,  A61N1/36135

摘要： The invention is directed to controlling therapy delivery based on a relative motion between a first and second activity sensor. The relative motion between the activity sensors is representative of the relative motion between the locations of the body of the patient at which the respective activity sensors are located. The use of relative motion, however, may substantially remove motion experienced by both the activity sensors, e.g., motion caused by the environment in which patient is located, thus providing a new reference frame from which to analyze the motion measurements. The relative motion may be used to detect a condition of a movement disorder and/or control delivery of the therapy delivered to patient to treat or reduce the condition.

摘要翻译： 本发明涉及基于第一和第二活动传感器之间的相对运动来控制治疗递送。 活动传感器之间的相对运动代表了相应活动传感器所位于的患者身体的位置之间的相对运动。 然而，相对运动的使用可以基本上消除活动传感器所经历的运动，例如由患者位于的环境引起的运动，从而提供新的参考框架，从中分析运动测量结果。 相对运动可以用于检测递送给患者的治疗或减少病症的运动障碍和/或控制递送的状况。

公开(公告)号：US20080269843A1

公开(公告)日：2008-10-30

申请号：US11799112

申请日：2007-04-30

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61N1/05

CPC分类号： G06F19/3418 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36571 ,  G06F19/00 ,  G06F19/3456 ,  G16H40/63

摘要： Systems and methods for adjusting a therapy delivered to a patient include detecting a value of at least one sensed patient parameter and adjusting a therapy program to accommodate different patient parameter values. A data structure including a plurality of patient parameter values and associated therapy programs may be stored within a medical device or a programming device. Upon detecting a patient parameter value, an associated therapy program from the data structure may be selected. If no therapy program is associated with the detected patient parameter value, an intermediate program that best suits the detected patient parameter value may be generated by interpolating between the most recently implemented therapy program and a stored therapy program. In some embodiments, the rate of shifting between parameters of two stored or interpolated therapy programs may be based on the rate of change of the patient parameter value over time.

摘要翻译： 用于调整递送给患者的治疗的系统和方法包括检测至少一个感测到的患者参数的值并且调整治疗程序以适应不同的患者参数值。 包括多个患者参数值和相关治疗程序的数据结构可以存储在医疗装置或编程装置内。 在检测到患者参数值时，可以选择来自数据结构的相关治疗程序。 如果没有治疗程序与检测到的患者参数值相关联，则可以通过在最近实施的治疗程序和存储的治疗程序之间进行内插来产生最适合检测到的患者参数值的中间程序。 在一些实施例中，两个存储或内插治疗程序的参数之间的偏移速率可以基于随时间推移的患者参数值的变化率。

公开(公告)号：US20080269763A1

公开(公告)日：2008-10-30

申请号：US11740049

申请日：2007-04-25

申请人： Eric H. Bonde ,  Martin T. Gerber

发明人： Eric H. Bonde ,  Martin T. Gerber

IPC分类号： A61B17/58

CPC分类号： A61B17/3468 ,  A61B17/3415 ,  A61B17/3417 ,  A61B17/3421 ,  A61B90/39 ,  A61B2017/00039 ,  A61B2017/00212 ,  A61B2017/00221 ,  A61B2017/00734 ,  A61B2017/00867 ,  A61M25/06 ,  A61M25/0631 ,  A61N1/0551

摘要： The disclosure is directed to an implant tool used to facilitate the implantation of a medical device into a patient. The implant tool includes a housing that is held by a user and a needle attached to the housing. The needle is configured so that a cannula may be positioned over the needle and delivered to the target tissue. The implant tool also includes a release mechanism that pushes the cannula off of the needle. The release mechanism may help the user to keep the cannula at the desired location while removing the needle from the cannula. The implant tool may also include a flange that extends from the housing adjacent to a side of the needle such that the user may provide force against the needle during advancement of the needle into the patient.

摘要翻译： 本公开涉及用于促进将医疗装置植入患者体内的植入工具。 植入物工具包括由使用者保持的壳体和附接到壳体的针。 针被构造成使得套管可以定位在针上方并被递送到目标组织。 植入工具还包括将套管从针上推出的释放机构。 释放机构可以帮助使用者将插管保持在期望的位置，同时从插管中移除针头。 植入工具还可以包括从壳体邻近针的一侧延伸的凸缘，使得使用者可以在针进入患者期间向针提供力。