摘要:
The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要:
A radio communication system performs radio communication between a terminal station installed on a vehicle and a plurality of base stations provided along a roadside. The system detects a vehicle traveling speed in each communication area formed by each base station. The vehicle traveling speed is detected by a method which uses radio communication between the terminal station and the base stations. The time of the vehicle stay in the communication area is estimated based on the detected vehicle traveling speed, and the length of a packet is determined based on the estimated time of the vehicle stay in the communication area. In this way, the present system performs data transmission using a packet of an appropriate length according to the detected vehicle traveling speed.
摘要:
The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要:
The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.
摘要:
An orally administrable uncompressed rapidly dissolving molded dosage form comprises a drug and either one or more saccharides or one saccharide and polyvinylpyrrolidone. Saccarides are chosen and used in proportion based on their solubilities. Methods for producing uncompressed rapidly dissolving solid preparations comprise mixing a drug and carriers according to the present invention and charging the mixture in a mold. Rapidly dissolving oral dosage forms facilitate administration of drugs to patients having a difficulty in swallowing such as children and the elderly.
摘要:
This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and biocompatibility, and (b) a drug. When applied directly to a joint area, this preparation can achieve a high drug concentration at the target area, can inhibit occurrence of general side effect, and can maintain drug efficacy over a long term. The preparation can therefore alleviate the burden on the patient.
摘要:
A carbostyril derivative of the formula (1): ##STR1## wherein A is lower alkylene, R is H, halogen or lower alkoxy, R.sup.1 and R.sup.2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl, R.sup.3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that when R and R.sup.3 are H, R.sup.1 and R.sup.2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.
摘要:
A multi-frequency quadrature modulated signal is divided into a plurality of frequency bands. Each frequency band component is estimated as to variation in phase due to multi-path phasing, using its guard interval waveform so as to compensate the variation.
摘要:
A magnetic card (10) has a base card (11), a magnetic stripe (12) formed on the base card (11), and a plurality of optical fibers (15) extended within the base card (11) substantially perpendicularly to the magnetic stripe (12). The magnetic stripe (12) consists of an arrangement of a plurality of unit magnetic segments (12a) each having a recording capacity of a predetermined number of bits, for example, eleven bits. The optical fibers (15) are assigned to the unit magnetic segments (12a), respectively. A read/write head (23) reads magnetic information from the magnetic stripe (12), an optical read device including a light-emitting device (20) and a light-receiving device (22) read optical information from the optical fibers (15), and a controller (25) examines the magnetic information with reference to the optical information to authenticate the magnetic information.
摘要:
An eddy current flaw detecting endoscope apparatus has an endoscope having an elongate insertable part and an objective optical system provided on the tip side of the insertable part. A flaw detecting device is provided on the tip side of the endoscope. A signal processing device processes a signal for the flaw detecting device. An eddy current flaw detecting apparatus detects a flaw in an object to be inspected and generates a flaw detecting signal. A controlling device generates a control signal controlling a controlled device with a flaw detecting signal of the eddy current flaw detecting apparatus.