公开(公告)号：US20130190810A1

公开(公告)日：2013-07-25

申请号：US13791829

申请日：2013-03-08

Applicant: Wouter E. Roorda ,  Kelly J. McCrystle ,  Ian J. Clark ,  Laveille K. Voss ,  Ni Ding

Inventor： Wouter E. Roorda ,  Kelly J. McCrystle ,  Ian J. Clark ,  Laveille K. Voss ,  Ni Ding

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00986 ,  A61B2017/00991 ,  A61B2090/0811

Abstract: A device for closing an opening in a wall of a body lumen includes a closure element with a first flange and a second flange. Both the first flange and the second flange may have a delivery cross-sectional dimension and a deployed cross-sectional dimension. The device for closing an opening further includes a first coupler element disposed on the first flange and a second coupler element disposed on the second flange, the first and second coupler elements cooperating to couple the first flange to the second flange.

Abstract translation: 用于关闭体腔内的开口的装置包括具有第一凸缘和第二凸缘的闭合元件。 第一凸缘和第二凸缘都可以具有输送横截面尺寸和展开的横截面尺寸。 用于关闭开口的装置还包括设置在第一凸缘上的第一耦合器元件和设置在第二凸缘上的第二耦合器元件，第一和第二耦合器元件协作以将第一凸缘耦合到第二凸缘。

公开(公告)号：US20130041129A1

公开(公告)日：2013-02-14

申请号：US13207656

申请日：2011-08-11

Applicant: Bethany Steichen ,  Stephen D. Pacetti ,  Manish Gada ,  Thierry Glauser ,  Lothar W. Kleiner ,  Yunbing Wang ,  James P. Oberhauser ,  Ni Ding

Inventor： Bethany Steichen ,  Stephen D. Pacetti ,  Manish Gada ,  Thierry Glauser ,  Lothar W. Kleiner ,  Yunbing Wang ,  James P. Oberhauser ,  Ni Ding

IPC: A61L31/06 ,  C08G63/90 ,  G05B1/00

CPC classification number: B29C47/0078 ,  B29B13/06 ,  B29B13/065 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/1018 ,  B29C47/1072 ,  B29C47/76 ,  B29C47/92 ,  B29C2947/922 ,  B29C2947/92228 ,  B29C2947/92342 ,  B29C2947/92695 ,  B29C2947/92704 ,  B29C2947/92723 ,  B29K2995/006

Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。

公开(公告)号：US20120328770A1

公开(公告)日：2012-12-27

申请号：US13605795

申请日：2012-09-06

Applicant: Shaw Ling Hsu ,  Ni Ding ,  Yiwen Tang ,  Fuh-Wei Tang ,  Lothar Walter Kleiner ,  Syed Faiyaz Ahmed Hossainy

Inventor： Shaw Ling Hsu ,  Ni Ding ,  Yiwen Tang ,  Fuh-Wei Tang ,  Lothar Walter Kleiner ,  Syed Faiyaz Ahmed Hossainy

IPC: B05D7/00

CPC classification number: A61L31/10 ,  A61F2240/001 ,  A61F2250/0056 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/60 ,  C08L33/10 ,  C08L27/16 ,  C08L27/20 ,  C08L29/04

Abstract: Methods for modulating the release rate of a drug coated stent are disclosed.

Abstract translation: 公开了调节药物涂层支架释放速率的方法。

公开(公告)号：US08293318B1

公开(公告)日：2012-10-23

申请号：US11847222

申请日：2007-08-29

Applicant: Shaw Ling Hsu ,  Ni Ding ,  Yiwen Tang ,  Fuh-Wei Tang ,  Lothar Walter Kleiner ,  Syed Faiyaz Ahmed Hossainy

Inventor： Shaw Ling Hsu ,  Ni Ding ,  Yiwen Tang ,  Fuh-Wei Tang ,  Lothar Walter Kleiner ,  Syed Faiyaz Ahmed Hossainy

IPC: B05D3/02 ,  A61L33/00 ,  A61F2/06

CPC classification number: A61L31/10 ,  A61F2240/001 ,  A61F2250/0056 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/60 ,  C08L33/10 ,  C08L27/16 ,  C08L27/20 ,  C08L29/04

Abstract: Methods for modulating the release rate of a drug coated stent are disclosed.

Abstract translation: 公开了调节药物涂层支架释放速率的方法。

公开(公告)号：US08007858B2

公开(公告)日：2011-08-30

申请号：US12363538

申请日：2009-01-30

Applicant: Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

IPC: A61L33/00

CPC classification number: B05D3/0466 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D3/0473 ,  B05D3/048 ,  Y10T428/1393 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: A method and system of coating an implantable device, such as a stent, are provided.

Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。

公开(公告)号：US07985441B1

公开(公告)日：2011-07-26

申请号：US11418697

申请日：2006-05-04

Applicant: Yiwen Tang ,  Stephen D. Pacetti ,  Qing Lin ,  Ni Ding

Inventor： Yiwen Tang ,  Stephen D. Pacetti ,  Qing Lin ,  Ni Ding

IPC: B05D3/00 ,  C08F6/28

CPC classification number: C08F6/005 ,  A61L31/10 ,  A61L2420/02 ,  C08L27/20 ,  C08L27/16

Abstract: Various embodiments of methods and devices for coating stents are described herein. Among these embodiments are methods of manufacturing an implantable medical device by purifying a polymer with a fluid capable of swelling the polymer, and subsequently coating a device with the purified polymer or fabricating a device from the purified polymer. A preferred polymer is poly(vinylidene fluoride-co-hexafluoropropylene).

Abstract translation: 本文描述了用于涂覆支架的方法和装置的各种实施例。 在这些实施方案中，通过用能够使聚合物膨胀的流体纯化聚合物，随后用纯化的聚合物涂覆装置或从纯化的聚合物制造装置来制造可植入医疗装置的方法。 优选的聚合物是聚（偏二氟乙烯 - 共 - 六氟丙烯）。

公开(公告)号：US07955615B2

公开(公告)日：2011-06-07

申请号：US11212376

申请日：2005-08-26

Applicant: Stephen D. Pacetti ,  Eugene T. Michal ,  Syed F. A. Hossainy ,  Ni Ding ,  Wouter E. Roorda

Inventor： Stephen D. Pacetti ,  Eugene T. Michal ,  Syed F. A. Hossainy ,  Ni Ding ,  Wouter E. Roorda

IPC: A61F2/04

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

公开(公告)号：US07875286B2

公开(公告)日：2011-01-25

申请号：US11213290

申请日：2005-08-26

Applicant: Stephen D. Pacetti ,  Eugene T. Michal ,  Syed F. A. Hossainy ,  Ni Ding ,  Wouter E. Roorda

Inventor： Stephen D. Pacetti ,  Eugene T. Michal ,  Syed F. A. Hossainy ,  Ni Ding ,  Wouter E. Roorda

IPC: A61F2/02

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

Abstract translation: 公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。

公开(公告)号：US07815561B2

公开(公告)日：2010-10-19

申请号：US10742445

申请日：2003-12-19

Applicant: Michael R. Forman ,  Darius Francescatti ,  Ni Ding

Inventor： Michael R. Forman ,  Darius Francescatti ,  Ni Ding

IPC: A61N5/00

CPC classification number: A61N5/1015 ,  A61N5/1027

Abstract: A breast brachytherapy applicator providing a stable semi permanent/permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent/decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.

Abstract translation: 一种乳房近距离放射治疗仪，其提供稳定的半永久/永久性住宅平台，其被配置为在解剖学上复制切除的癌床，并允许更精确的解剖学上正确的有限的放射治疗递送。 该装置可用于将切除的组织空间重建为其手术前的大小和形状，以便于1）促进乳腺癌手术后辅助乳房近距离放射治疗的准确和精确的传递，以及2）由于以下原因：预防/减少术后畸形 手术切除，无论是良性还是恶性疾病，特别是放射治疗乳房肿瘤切除术后患者的恶性疾病。

公开(公告)号：US07803406B2

公开(公告)日：2010-09-28

申请号：US11213288

申请日：2005-08-26

Applicant: Stephen D. Pacetti ,  Eugene T. Michal ,  Syed F. A. Hossainy ,  Ni Ding ,  Wouter E. Roorda

Inventor： Stephen D. Pacetti ,  Eugene T. Michal ,  Syed F. A. Hossainy ,  Ni Ding ,  Wouter E. Roorda

IPC: A61K9/50

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.

Abstract translation: 公开了形成包含用于医疗装置的聚阳离子肽的涂层的方法。 还公开了包含聚阳离子肽的涂层。