公开(公告)号：US20090118609A1

公开(公告)日：2009-05-07

申请号：US11983027

申请日：2007-11-06

Applicant: Norbert Rahn

Inventor： Norbert Rahn

IPC: A61B6/00 ,  A61B18/12 ,  A61B5/055

CPC classification number: A61B6/12 ,  A61B5/7289 ,  A61B18/1492 ,  A61B34/25 ,  A61B34/30 ,  A61B90/361 ,  A61B2018/00351 ,  A61B2018/00839 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2034/301 ,  A61B2090/3762

Abstract: A system and method of treating tachycardias and similar syndromes by the use of catheter ablation of tissue is described. A computed tomography (CT)-like image of the heart is obtained and processed to segment the various types of tissue. Papillary muscle areas are identified and displayed differently from the other nearby tissues so that the muscles can be avoided during treatment to avoid or minimize damage to the muscles during ablation treatment. Electrophysical data and scar tissue may also be identified in the image, which may be of the endoscopic type. The position of the catheter may be displayed as a synthetic image on the endoscopic view.

Abstract translation: 描述了通过使用导管消融组织治疗心动过速和类似综合征的系统和方法。 获得心脏的计算机断层摄影（CT）样图像并进行处理以分割各种类型的组织。 识别和显示乳头肌区域与其他附近组织不同，使得在治疗期间可以避免肌肉以避免或最小化在消融治疗期间对肌肉的损伤。 也可以在图像中识别电物理数据和瘢痕组织，其可以是内窥镜型。 导管的位置可以在内窥镜视图上显示为合成图像。

公开(公告)号：US20090082660A1

公开(公告)日：2009-03-26

申请号：US12233230

申请日：2008-09-18

Applicant: Norbert Rahn ,  Stefan Lautenschlager

Inventor： Norbert Rahn ,  Stefan Lautenschlager

IPC: A61B5/05 ,  A61B6/00 ,  A61B18/14

CPC classification number: A61B6/504 ,  A61B5/7285 ,  A61B5/7289 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/463 ,  A61B6/466 ,  A61B6/481 ,  A61B6/527 ,  A61B6/541 ,  A61B6/547 ,  A61B18/1492 ,  A61B2018/00577 ,  G06T5/50 ,  G06T7/12 ,  G06T2207/10081 ,  G06T2207/10121 ,  G06T2207/20221 ,  G06T2207/30048

Abstract: A system and method of treatment of a patient in a catheterization laboratory is described. A three dimensional (3D) voxel data set of the patient is obtained using a computed tomography device. The data is displayed in a multiplanar slice format, or as a segmented 3D image, and a particular bodily structure identified. The identified structure coordinates are registered, if necessary, with respect to the patient when the patient is positioned for obtaining real-time fluoroscopic images during the treatment, and the bodily structure information is superimposed on the displayed fluoroscopic image. The treatment may be, for example, an electrophysiological (EP) ablation procedure for atrial fibrulation.

Abstract translation: 描述了在导管实验室中治疗患者的系统和方法。 使用计算机断层摄影装置获得患者的三维（3D）体素数据集。 数据以多平面切片格式显示，或以分割的3D图像显示，并标识特定的身体结构。 如果需要，在患者被定位以获得实时荧光透视图像的处理期间，如果必要，登记所识别的结构坐标，并且将身体结构信息叠加在所显示的荧光透视图像上。 该治疗可以是例如心房纤颤的电生理（EP）消融手术。

公开(公告)号：US07480398B2

公开(公告)日：2009-01-20

申请号：US11076536

申请日：2005-03-08

Applicant: Martin Kleen ,  Marcus Pfister ,  Norbert Rahn

Inventor： Martin Kleen ,  Marcus Pfister ,  Norbert Rahn

IPC: G06K9/00 ,  G06K9/36 ,  A61B5/05

CPC classification number: G06T3/0037 ,  A61B8/12 ,  A61B8/483 ,  A61B8/5238 ,  G06T7/33 ,  G06T7/38 ,  G06T7/66 ,  G06T2207/30101

Abstract: The present invention relates to a method for registration of a sequence of 2D image data (5) of a hollow channel (2), in particular of a vessel, recorded with an imaging endoluminal instrument (1) when the relative displacement positions of the instrument (1) in the hollow channel (2) are known, with 3D image data (8) of the hollow channel (2). In the method a three-dimensional path of a central axis (10) of a definable section of the hollow channel (2) is determined from the 3D image data (8), the three-dimensional path of the central axis (10) is converted into a rectilinear path by a first transformation of the 3D image data (8) of the definable section of the hollow channel (2) and transformation parameters required for the first transformation are stored. A combined 3D image data record (11) is generated from the sequence of 2D image data (5) by a parallel side-by-side arrangement on a central straight line in accordance with the known relative displacement positions, and is first registered with the transformed 3D image data (9) by equating the central straight line with the rectilinear path of the central axis (10) and suitable translation for superposition of a shared reference point. The combined 3D image data record (11) or 2D image data (5) contained therein is then registered with the 3D image data (3), taking into account the stored transformation parameters.

Abstract translation: 本发明涉及用于记录仪器的相对位移位置时记录有成像腔内仪器（1）的中空通道（2）的二维图像数据序列（2）的序列的方法，特别是记录有成像腔内仪器（1）的容器 （2）中的3D图像数据（8）已知在空心通道（2）中的（1）。 在该方法中，根据3D图像数据（8）确定空心通道（2）的可定义部分的中心轴线（10）的三维路径，中心轴线（10）的三维路径为 通过中空通道（2）的可定义部分的3D图像数据（8）的第一变换，转换为直线路径，并存储第一变换所需的变换参数。 根据已知的相对位移位置，通过平行并排布置在中央直线上从2D图像数据（5）的序列生成组合的3D图像数据记录（11），并且首先与 通过将中心直线与中心轴线（10）的直线路径相等，以及用于叠加共享参考点的合适的平移来改变3D图像数据（9）。 然后将其中包含的组合3D图像数据记录（11）或2D图像数据（5）与3D图像数据（3）一起注册，同时考虑所存储的变换参数。

公开(公告)号：US07479141B2

公开(公告)日：2009-01-20

申请号：US10992181

申请日：2004-11-18

Applicant: Martin Kleen ,  Norbert Rahn

Inventor： Martin Kleen ,  Norbert Rahn

IPC: A61B18/18

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/042 ,  A61B8/12 ,  A61B18/1492 ,  A61B90/361 ,  A61B2018/00839

Abstract: Catheter device comprising a catheter (2), particularly an intravascular catheter, for insertion into an organ or vessel of the human or animal body, with a device for ablation of the adjacent organ tissue or vessel tissue using high-frequency currents in the region of the tip of the catheter, a device (3, 11, 12, 18, 19, 23, 24) being integrated for capturing images of the organ or vessel in the region of the tip of the catheter (10, 17, 22).

Abstract translation: 导管装置包括导管（2），特别是血管内导管，用于插入到人体或动物体的器官或血管中，其具有用于在邻近的器官组织或血管组织的区域中使用高频电流 导管的尖端，被整合用于捕获在导管（10,17,22）的尖端区域中的器官或血管的图像的装置（3,11,12,18,19,23,24）。

公开(公告)号：US20080147086A1

公开(公告)日：2008-06-19

申请号：US11544846

申请日：2006-10-05

Applicant: Marcus Pfister ,  Michael Maschke ,  Jan Boese ,  Norbert Rahn

Inventor： Marcus Pfister ,  Michael Maschke ,  Jan Boese ,  Norbert Rahn

IPC: A61B19/00

CPC classification number: A61B90/36 ,  A61B34/10 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/364

Abstract: Three-dimensional image datasets are used to assist in the visualization of an interventional procedure. The three-dimensional image datasets are registered to two-dimensional images acquired by a medical imaging device. A display device can display a fusion visualization of the three-dimensional image datasets and the two-dimensional image. A monitoring device can monitor the progress of a medical instrument used in the interventional procedure. A processor can incorporate the position of the medical instrument in the fusion visualization displayed by the display device.

Abstract translation: 三维图像数据集用于辅助介入程序的可视化。 将三维图像数据集登记到由医学成像装置获取的二维图像。 显示装置可以显示三维图像数据集和二维图像的融合可视化。 监测装置可以监测介入手术中使用的医疗仪器的进度。 处理器可以将医疗仪器的位置结合在由显示装置显示的融合可视化中。

公开(公告)号：US20080056447A1

公开(公告)日：2008-03-06

申请号：US11897372

申请日：2007-08-30

Applicant: Jan Boese ,  Norbert Rahn

Inventor： Jan Boese ,  Norbert Rahn

IPC: G01N23/04 ,  G06K5/00

CPC classification number: A61B6/504 ,  A61B6/4441 ,  A61B6/541

Abstract: The invention relates to a method for providing a 3D x-ray image data record of a patient, in particular of the heart, by an x-ray imaging system connected to a measuring facility which monitors the breathing phases of the patient. The x-ray image system is automatically activated repeatedly when a predetermined breathing phase is reached and an image acquisition operation is carried out, during which a plurality of 2D x-ray images are recorded. An individual 3D image data record is reconstructed from the 2D x-ray images of each image acquisition operation and the different 3D image data records are registered in pairs in order to assign them in a correct positional and dimensional arrangement. Registration parameters are obtained during the registration. The 3D image data record is reconstructed from 2D x-ray images from all image acquisition operations using the registration parameters.

Abstract translation: 本发明涉及一种用于通过连接到监测患者的呼吸阶段的测量设备的x射线成像系统来提供患者，特别是心脏的3D X射线图像数据记录的方法。 当达到预定呼吸阶段并且执行图像获取操作时，X射线图像系统被重复地自动激活，在此期间记录多个2D X射线图像。 从每个图像获取操作的2D X射线图像重建单独的3D图像数据记录，并且成对登记不同的3D图像数据记录，以便将它们分配在正确的位置和尺寸排列中。 在注册期间获得注册参数。 使用注册参数从所有图像获取操作的2D x射线图像重建3D图像数据记录。

公开(公告)号：US20070248262A1

公开(公告)日：2007-10-25

申请号：US11725517

申请日：2007-03-19

Applicant: Jan Boese ,  Andreas Meyer ,  Norbert Rahn ,  Bernhard Sandkamp

Inventor： Jan Boese ,  Andreas Meyer ,  Norbert Rahn ,  Bernhard Sandkamp

IPC: G06K9/00

CPC classification number: A61B6/541 ,  A61B5/7285 ,  A61B6/503 ,  A61B90/36 ,  A61B90/37 ,  A61B2090/3612 ,  A61B2090/364

Abstract: The present invention relates to a device and a method for synchronizing an image capture device with a first image data set. The image capture device is used for recording a second image data set of a periodically moving area or object. Each first image data set contains information as to the point in time, relative to the periodically moving area or object, when recording took place. The device additionally acquires periodically recurring, current information of the area as well as information concerning the recording instant of the first image data set. From the periodically recurring information and the recording instant of the first image data set, a triggering instant is derived which controls at least one recording of the second image data set by the image capture device in such a way that the second image data set contains image data synchronized to the first image data set.

Abstract translation: 本发明涉及一种用于使图像捕获装置与第一图像数据组同步的装置和方法。 图像捕获装置用于记录周期性移动的区域或对象的第二图像数据集。 当记录发生时，每个第一图像数据集包含关于相对于周期性移动的区域或对象的时间点的信息。 该设备还周期性地获取周期性地重复出现的该区域的当前信息以及关于第一图像数据集的记录时刻的信息。 从第一图像数据集的周期性重复信息和记录时刻，导出触发时刻，其控制由图像捕获装置设置的第二图像数据的至少一次记录，使得第二图像数据集包含图像 与第一图像数据集同步的数据。

公开(公告)号：US20070238952A1

公开(公告)日：2007-10-11

申请号：US11496069

申请日：2006-07-28

Applicant: Jan Boese ,  Martin Kleen ,  Klaus Klingenbeck-Regn ,  Marcus Pfister ,  Norbert Rahn

Inventor： Jan Boese ,  Martin Kleen ,  Klaus Klingenbeck-Regn ,  Marcus Pfister ,  Norbert Rahn

IPC: A61B5/05

CPC classification number: G06T7/55 ,  G06T7/38 ,  G06T7/50 ,  G06T2207/30004

Abstract: The invention relates to a method for registering intra-operative image data set with pre-operative 3D image data set, comprising: spatial calibrating an optical 3D sensor system with an intra-operative imaging modality, intra-operative detecting the surface of an examination area of interest with the 3D sensor system to produce an intra-operative surface mask, intra-operative recording the area of interest for examination with the intra-operative modality at least partly containing the intra-operative surface mask to obtain an intra-operative image data set, computing the same surface from the pre-operative 3D image data set containing the detected surface to obtain a pre-operative surface mask, registering the intra-operative and pre-operative surface mask with each other, determining a mapping specification between pre-operative 3D image data set and intra-operative image data set based on the calibration and the registration, and overlaying the intra-operative image data set with the pre-operative 3D data set based on the mapping specification.

Abstract translation: 本发明涉及一种用于记录术前图像数据组与手术前3D图像数据集的方法，包括：用术中成像模态对光学3D传感器系统进行空间校准，手术中检测检查区域的表面 感兴趣的3D传感器系统以产生术中表面掩模，用至少部分地包含术中表面掩模的手术内模式手术内记录用于检查的感兴趣区域以获得手术中图像数据 设置，从包含检测到的表面的术前3D图像数据集计算相同的表面，以获得术前表面掩模，将手术前和手术前表面掩模彼此对准， 基于校准和注册的手术3D图像数据集和手术中图像数据集，并且将术中图像数据集合与t 他基于映射规范进行手术前3D数据集。

公开(公告)号：US20070232899A1

公开(公告)日：2007-10-04

申请号：US11729756

申请日：2007-03-29

Applicant: Ulrich Bill ,  Jan Boese ,  Norbert Rahn ,  Bernhard Sandkamp

Inventor： Ulrich Bill ,  Jan Boese ,  Norbert Rahn ,  Bernhard Sandkamp

IPC: A61B5/05

CPC classification number: A61B5/06 ,  A61B5/0515 ,  A61B5/062 ,  A61B34/20 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2090/376 ,  A61B2090/3954 ,  A61M25/01

Abstract: The invention is based on a new type of method which can be used to localize magnetizable small particles. According to the invention an invasive instrument, a catheter for example, is provided with a magnetizable marker, whereby a magnetic fluid is arranged in a fluid container. Such an invasive instrument can be localized during an invasive intervention on a patient by using a coil system which on the one hand generates an inhomogeneous basic magnetic field and on the other hand generates a superimposed temporally varying magnetic field. Previous localization methods, which are considerably more complex, can be dispensed with.

Abstract translation: 本发明基于可用于定位可磁化小颗粒的新型方法。 根据本发明，例如具有可磁化标记的入侵器械，例如导管，由此将磁性流体布置在流体容器中。 通过使用一方面产生不均匀的基本磁场并且另一方面产生叠加的时间上不同的磁场的线圈系统，这种侵入性器械可以在对患者的侵入性介入期间进行局部化。 以前的定位方法，这些方法要复杂得多，可以省略。

公开(公告)号：US20070167700A1

公开(公告)日：2007-07-19

申请号：US11314589

申请日：2005-12-21

Applicant: Norbert Rahn ,  Jan Boese ,  Martin Kleen

Inventor： Norbert Rahn ,  Jan Boese ,  Martin Kleen

IPC: A61B5/05

CPC classification number: A61B17/3478 ,  A61B34/20 ,  A61B90/36 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/376 ,  A61K35/12 ,  A61M25/0082 ,  A61M25/0084 ,  A61M2025/0091

Abstract: In a method for accurately delivering a therapeutic agent to a target area of an organ of a living subject, such as for injecting stem cells into the myocardium of the heart, a 3D image, in which the target area and a delivery path thereto are visible, is obtained prior to delivery of the therapeutic agent. The 3D image is displayed, and a catheter is introduced into the subject and a real time positional indication of the catheter in the subject is obtained and incorporated into the displayed image, providing visual support for guiding the catheter to the target area. When the catheter is at the target area, the therapeutic agent is injected into the target area via the catheter. The distribution of the injected therapeutic agent relative to the target area is then monitored in the displayed image.

Abstract translation: 在将用于将干细胞注入心脏心脏的活体受试者的器官的目标区域精确输送的方法中，其中目标区域和其输送路径可见的3D图像 在递送治疗剂之前获得。 显示3D图像，并且将导管引入到对象中，并且获得被检体内的导管的实时位置指示并将其合并到所显示的图像中，从而提供用于将导管引导到目标区域的视觉支撑。 当导管位于目标区域时，经由导管将治疗剂注入目标区域。 然后在所显示的图像中监测注射的治疗剂相对于目标区域的分布。