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170 条记录 (耗时 0.077 秒)

    Antisense oligonucleotide inhibition of the ras gene
    104.
    发明授权
    Antisense oligonucleotide inhibition of the ras gene 失效
    反义寡核苷酸抑制ras基因

    公开(公告)号：US5582986A

    公开(公告)日：1996-12-10

    申请号：US293086

    申请日：1994-08-19

    申请人： Brett P. Monia ,  Susan M. Freier ,  David J. Ecker

    发明人： Brett P. Monia ,  Susan M. Freier ,  David J. Ecker

    IPC分类号： A61K38/00 ,  C07K14/82 ,  C12N9/02 ,  C12N15/113 ,  C12Q1/68 ,  A61K31/70 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1135 ,  C07K14/82 ,  C12N9/0069 ,  C12Q1/6886 ,  A61K38/00 ,  C07K2319/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12N2310/3535 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from the human ras gene, having nucleotide units sufficient in identity and number to effect such specific hybridization. Oligonucleotides or oligonucleotide analogs specifically hybridizable with a translation initiation site or with the codon-12 mutation of activated ras are provided. Such oligonucleotides and oligonucleotide analogs can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides or oligonucleotide analogs provided, and for specific modulation of expression of the activated ras gene. Methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene are also disclosed.

    摘要翻译： 提供组合物和方法用于调节正常和活化形式的人ras基因的表达。 提供了与来自人ras基因的RNA或DNA特异性杂交的寡核苷酸，其具有足以实现这种特异性杂交的同一性和数目的核苷酸单元。 提供了与翻译起始位点或活化ras的密码子-12突变特异性杂交的寡核苷酸或寡核苷酸类似物。 这样的寡核苷酸和寡核苷酸类似物可用于诊断以及用于研究目的。 还公开了使用提供的寡核苷酸或寡核苷酸类似物以及用于特异性调节活化的ras基因的表达来调节细胞和组织中的ras基因表达的方法。 还公开了用于诊断，检测和治疗由H-ras基因激活引起的病症的方法。

    Compositions and methods for modulating &bgr;-amyloid
    110.
    发明授权
    Compositions and methods for modulating &bgr;-amyloid 失效
    用于调节β-淀粉样蛋白的组合物和方法

    公开(公告)号：US06177246B1

    公开(公告)日：2001-01-23

    申请号：US09192657

    申请日：1998-11-16

    申请人： Brett P. Monia ,  Susan M. Freier ,  David J. Ecker

    发明人： Brett P. Monia ,  Susan M. Freier ,  David J. Ecker

    IPC分类号： C12Q168

    CPC分类号： A61K31/70 ,  C07H21/00 ,  C07K14/4711 ,  C07K2319/00 ,  C12N9/0069 ,  C12N15/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： Compositions and methods are provided for the modulation of abnormal expression of &bgr;-amyloid. oligonucleotides are provided which are specifically hybridizable with RNA or DNA encoding &bgr;-amyloid. Oligonucleotides specifically hybridizable with a translation initiation site, codon 717, codon 670 or codon 671 of RAPP are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating &bgr;-amyloid expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the mutant RAPP gene. Methods for diagnosis, detection and treatment of diseases associated with abnormal &bgr;APP expression are also disclosed.

    摘要翻译： 提供了用于调节β-淀粉样蛋白异常表达的组合物和方法。 提供了与编码β-淀粉样蛋白的RNA或DNA特异性杂交的寡核苷酸。 提供与翻译起始位点，密码子717，密码子670或betaAPP密码子671特异性杂交的寡核苷酸。 这样的寡核苷酸可用于诊断以及用于研究目的。 还公开了使用提供的寡核苷酸调节细胞和组织中β-淀粉样蛋白表达的方法，以及用于突变型βAPP基因表达的特异性调节。 还公开了与异常βAPP表达相关的疾病的诊断，检测和治疗的方法。