公开(公告)号：US20140319042A1

公开(公告)日：2014-10-30

申请号：US14273040

申请日：2014-05-08

Applicant: Waters Technologies Corporation

Inventor： David P. Prentice ,  Russell L. Keene ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Paul E. Linderson

IPC: B01D15/10 ,  B05B1/02

CPC classification number: B01D15/10 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0883 ,  B05B1/00 ,  B05B1/02 ,  G01N27/44791 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/724 ,  G01N30/7266 ,  H01J49/167 ,  Y10T137/598 ,  Y10T436/24

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

Abstract translation: 一种用于化学分离的装置包括具有用于输出样品洗脱液的出口孔的微流体衬底，具有用于接收洗脱液的入口的喷雾单元和用于喷射洗脱液的出口以及施力单元。 喷射单元具有限定入口的可变形部分，并且具有低于微流体衬底的弹性模量的弹性模量。 力施加单元（例如弹簧）被设置成推动与基底接触的可变形部分以形成基本上流体密封的密封。