公开(公告)号：US5434663A

公开(公告)日：1995-07-18

申请号：US977446

申请日：1993-04-15

申请人： Colin H. Maule

发明人： Colin H. Maule

IPC分类号： G01N21/27 ,  G01N21/41 ,  G01N21/55 ,  G01N21/64 ,  G01N21/75 ,  G01N33/543 ,  G01J3/00

CPC分类号： G01N33/54373 ,  G01N21/552

摘要： A sensor, particularly a resonant optical biosensor based on the principle of frustrated total reflection, includes an optical structure comprising: a) a cavity layer (3) of transparent dielectric material of refractive index n.sub.3, b) a dielectric substrate (1) of refractive index n.sub.1, and c) interposed between the cavity layer (3) and the substrate (1), a dielectric spacer layer (2) of refractive index n.sub.2. The arrangement is such that the optical structure may be illuminated by a beam of incident radiation, internal reflection occurring at the interface between the substrate (1) and the spacer layer (2). The device is characterised in that the cavity layer (3) or the spacer layer (2) absorbs at the wavelength of the incident radiation. The cavity layer (3) or the spacer layer (2) comprises a material which is either absorbing or is doped with an absorbing species, most preferably a fluorophore.

摘要翻译： PCT No.PCT / GB91 / 01161 Sec。 371日期：1993年4月15日 102（e）日期1993年4月15日PCT提交1991年7月12日PCT公布。 公开号WO92 / 03720 日本1993年3月5日。一种传感器，特别是基于沮丧全反射原理的共振光学生物传感器，包括一种光学结构，包括：a）折射率为n3的透明介电材料的空腔层（3），b） 折射率为n1的电介质基板（1），以及c）插入在空腔层（3）和基板（1）之间的折射率为n2的电介质间隔层（2）。 该布置使得光学结构可以被入射辐射束照射，在衬底（1）和间隔层（2）之间的界面处发生内反射。 该器件的特征在于，空腔层（3）或间隔层（2）在入射辐射的波长处吸收。 空腔层（3）或间隔层（2）包括吸收或掺杂有吸收物质的材料，最优选荧光团。

公开(公告)号：US5354988A

公开(公告)日：1994-10-11

申请号：US70372

申请日：1993-06-02

申请人： Paul Jullien

发明人： Paul Jullien

IPC分类号： G01N23/225 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/4215 ,  H01J49/022

摘要： A quadrupole mass filter (1) includes a controllable RF oscillator (7) which follows any drift in the resonant frequency of a resonant circuit means (8), this circuit means (8) amplifying an alternating RF potential from the oscillator (7) and supplying it to the filter electrodes (2, 3, 4, 5). To ensure that the charge to mass ratio of the particles transmitted by the filter remains constant, a signal for controlling the amplitude of the oscillator (7) is corrected in response to any resonant frequency shift. This signal is also fed to DC supply means (12, 13, 15), to ensure that the amplitude of the DC potential applied to the electrodes (2, 3, 4, 5) remains in the correct ratio to the RF potential amplitude so that the filter resolution remains constant.

摘要翻译： PCT No.PCT / GB92 / 01961 Sec。 371日期：1993年6月2日 102（e）日期1993年6月2日PCT提交1992年10月26日PCT公布。 公开号WO93 / 08590 日本四月29日，1993.四极质量过滤器（1）包括可控制的RF振荡器（7），其遵循谐振电路装置（8）的谐振频率中的任何漂移，该电路装置（8）放大交替的RF电位 来自振荡器（7）并将其提供给滤波电极（2,3,4,5）。 为了确保由滤波器传输的颗粒的质量比保持恒定，响应于任何谐振频率偏移来校正用于控制振荡器（7）振幅的信号。 该信号也被馈送到DC电源装置（12,13,15），以确保施加到电极（2,3,4,5）的DC电位的幅度与RF电位振幅保持正确的比例，所以 滤波器分辨率保持不变。

公开(公告)号：US5341800A

公开(公告)日：1994-08-30

申请号：US897246

申请日：1992-06-11

申请人： Andrew R. Clark ,  John L. Hart

发明人： Andrew R. Clark ,  John L. Hart

IPC分类号： A61M15/00 ,  A61K9/16 ,  B65D83/06

CPC分类号： A61M15/0065 ,  A61M2202/066 ,  Y10S514/826

摘要： A method of compacting and administering a powdered inhalation medicament for use in an inhalation device includes compacting a body of loosely powdered inhalation medicament such that the degree of compaction is sufficient to hold the body together solely due to the force of compaction and placing the compacted body into the inhalation device and abrading the compacted body to obtain a plurality of unit doses of the medicament.

摘要翻译： 一种压实和施用用于吸入装置的粉末状吸入药物的方法包括压实松散粉末状吸入药物的主体，使得压实程度足以将其整体固定在一起，这仅仅是由于压实的力而将压实体 进入吸入装置并研磨压实体以获得多个单位剂量的药物。

公开(公告)号：US5285251A

公开(公告)日：1994-02-08

申请号：US512792

申请日：1990-04-23

申请人： Francis Pilloud ,  Wilfried Vogel

发明人： Francis Pilloud ,  Wilfried Vogel

IPC分类号： G01N21/67 ,  H03K3/57 ,  H03K4/00 ,  H03K4/02 ,  G01J3/30

CPC分类号： H03K4/02 ,  G01N21/67 ,  H03K3/57 ,  H03K4/00

摘要： A spark generator suitable for use in an optical emission spectrometer, and capable of generating a spark in a spark gap formed between an electrode and a sample to be analyzed, comprises a generator for generating a current of programmable amplitude in the spark gap in each of a series of discrete time intervals. The spark generator according to the invention is advantageous when compared with conventional spark generators in that it enables a higher degree of choice and control in the form of the spark. In particular, it enables the amplitudes of various portions of the spark to be independently varied, thus permitting the shape of the spark to be tailored to the particular analysis being performed. Also described are methods of optical emission spectroscopy which make use of the advantageous properties of the spark generator.

摘要翻译： 一种适用于光发射光谱仪并且能够在电极和待分析样品之间形成的火花间隙中产生火花的火花发生器包括：发生器，用于产生在每一个中的火花隙中的可编程幅度的电流 一系列离散的时间间隔。 根据本发明的火花发生器与常规火花发生器相比是有利的，因为它能够以火花的形式进行更高程度的选择和控制。 特别地，它使得火花的各个部分的幅度可以独立地变化，从而允许火花的形状适合于正在执行的特定分析。 还描述了利用火花发生器的有利特性的光发射光谱法的方法。

公开(公告)号：US5260306A

公开(公告)日：1993-11-09

申请号：US727322

申请日：1991-07-02

申请人： Terence D. Boardman ,  Raymond B. Forrester

发明人： Terence D. Boardman ,  Raymond B. Forrester

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/47 ,  A61K31/44

CPC分类号： A61K9/0075 ,  A61K31/47 ,  A61K9/1688 ,  Y10S514/826 ,  Y10S514/951

摘要： There is described finely divided nedocromil sodium, comprising a therapeutically effective proportion of individual particles capable of penetrating deep into the lung, characterized in that a bulk of the particles which is both unaggolomerated and unmixed with a coarse carrier, is sufficiently free flowing to be filled into capsules on an automatic filling machine and to empty from an opened capsule in an inhalation device.There is also described a method of making the fine particles and pharmaceutical formulations containing them.

摘要翻译： 描述了细分的奈多罗米钠，其包含能够深入肺部的治疗有效比例的单个颗粒，其特征在于，大部分未粗调和未与粗制载体混合的颗粒的体积足够自由地流动以被填充 在自动灌装机中的胶囊中，并从吸入装置中的打开的胶囊中排空。 还描述了制备含有它们的细颗粒和药物制剂的方法。

公开(公告)号：US5198221A

公开(公告)日：1993-03-30

申请号：US835014

申请日：1992-02-12

申请人： Andrew R. Clark ,  Anne M. Hollingworth

发明人： Andrew R. Clark ,  Anne M. Hollingworth

IPC分类号： A61K9/00 ,  A61K31/47

CPC分类号： A61K9/0075 ,  A61K31/47

摘要： Particulate nedocromil sodium with a mass median diameter of from 5 to 10 .mu.m is useful as a medicament for inhalation.The particulate nedocromil sodium of the invention is particularly advantageous in that its dispersion, i.e. the proportion of particles which are capable of penetrating deep into the lung, is substantially greater than the dispersion of conventional powders having smaller mass median diameters.

摘要翻译： 质量中值粒径为5至10微米的粒状奈多罗米钠可用作吸入药物。 本发明的颗粒尼多菌素钠是特别有利的，因为其分散体，即能够深入肺的颗粒的比例基本上大于具有较小质量中值直径的常规粉末的分散体。

公开(公告)号：US5179087A

公开(公告)日：1993-01-12

申请号：US568855

申请日：1990-08-17

申请人： David K. Donald ,  David N. Hardern ,  Martin E. Cooper ,  Mark Furber

发明人： David K. Donald ,  David N. Hardern ,  Martin E. Cooper ,  Mark Furber

IPC分类号： C07D498/18 ,  A61K31/445 ,  A61P37/06 ,  C07H19/01

CPC分类号： C07H19/01

摘要： There are described compounds of formula I, ##STR1## wherein R.sup.1 represents H or OH; R.sup.2 represents H; in addition, R.sup.1 and R.sup.2 may together represent a second carbon-carbon bond between the carbon atoms to which they are attached; R.sup.3 represents OH or OCH.sub.3 ; X represents O or (H,OH); and Y represents O or N--OR.sup.4, in which R.sup.4 represents H or alkyl C.sub.1-6 ; provided that when R.sup.1 is OH, R.sup.2 is H and X is O, then Y does not represent O.Processes for their production and compositions containing them, eg. for use as immunosuppressive agents, are also described.

公开(公告)号：US4935244A

公开(公告)日：1990-06-19

申请号：US272706

申请日：1988-11-17

申请人： Andrew R. Clark

发明人： Andrew R. Clark

IPC分类号： A61K9/127 ,  A61K31/47 ,  A61P11/00 ,  A61P11/08 ,  C07D491/052

CPC分类号： A61K31/47 ,  A61K9/127

摘要： There is described a pharmaceutical composition comprising nedocromil sodium and liposomes.There is also described an aqueous suspension comprising nedocromil sodium partitioned between a free aqueous phase and a liposome phase.There ae also described a method of making the compositions and their use in the manufacture of a medicament for the treatment of reversible obstructive airways disease.

公开(公告)号：US4922022A

公开(公告)日：1990-05-01

申请号：US195722

申请日：1988-05-18

申请人： John Dixon ,  Brian Springthorpe ,  Francis Ince

发明人： John Dixon ,  Brian Springthorpe ,  Francis Ince

IPC分类号： C07C313/00 ,  C07C67/00 ,  C07C213/00 ,  C07C215/54 ,  C07C231/00 ,  C07C231/12

CPC分类号： C07C215/54

摘要： Novel compounds of the formula ##STR1## in which one of R.sub.30 and R.sub.40 represents a substituted phenylalkyl group,the other of R.sub.30 and R.sub.40 represents hydrogen or halogen, andR.sub.50 and R.sub.60 each independently represent hydrogen or alkyl; in addition R.sub.60 may represent a substituted alkyl chain interrupted by N.The compounds of the invention are useful for the treatment or prophylaxis of renal failure or cardiovascular disease.

公开(公告)号：US4914126A

公开(公告)日：1990-04-03

申请号：US102781

申请日：1987-09-23

申请人： John Dixon ,  Francis Ince

发明人： John Dixon ,  Francis Ince

IPC分类号： A61K31/135 ,  A61K31/38 ,  C07C20060101 ,  C07C317/04 ,  C07C323/25 ,  C07D20060101 ,  C07D333/20

CPC分类号： C07C323/25 ,  C07C323/00 ,  C07D333/20

摘要： ##STR1## Compounds of formula (I), in which Z represent O, S, SO
2 , CO, NR or a single bond, G represents a one or two ring, saturated or unsaturated carbocyclic or heterocyclic group optionally substituted by phenyl thrihalomethyl or at least groups selected from alkoxy C1 to 6 or halogen atoms, provided that when Z represents a single bond G does not represent phenyl, R represents hydrogen or alkyl C1-6, m and n each independently represent 2, 3 or 4, and q represents an integer from 1 to 3 inclusive, and pharmaceutically acceptable derivatives thereof. There are also described processes for producing the compounds and pharmaceutical, e.g. cardiac, compositions containing them.

摘要翻译： 其中Z表示O，S，SO2，CO，NR或单键的式（I）化合物，G表示任选被苯基三卤代甲基取代的一个或两个环，饱和或不饱和的碳环或杂环基， 至少选自烷氧基C1至6或卤原子的基团，条件是当Z表示单键时，G不表示苯基，R表示氢或C1-6烷基，m和n各自独立地表示2,3或4，且q 表示1〜3的整数，以及其药学上可接受的衍生物。 还描述了用于生产化合物和药物的方法，例如。 心脏，含有它们的组合物。