公开(公告)号：US20230390376A1

公开(公告)日：2023-12-07

申请号：US18453684

申请日：2023-08-22

申请人： Intervet Inc.

发明人： Antonius Arnoldus Christiaan Jacobs

IPC分类号： A61K39/09

CPC分类号： A61K39/092 ,  C12N9/52

摘要： The present invention pertains to a vaccine comprising an immunologically effective amount of an IgM protease antigen of Streptococcus suis, for use in a method for protecting pigs against a pathogenic infection with Streptococcus suis by administering the vaccine only once, wherein the vaccine comprises at most 120 μg per dose of the antigen.

公开(公告)号：US20230250177A1

公开(公告)日：2023-08-10

申请号：US17785232

申请日：2020-12-18

申请人： Intervet Inc.

发明人： Mohamad Morsey ,  Yuanzheng Zhang ,  Anasuya Saha

IPC分类号： C07K16/28 ,  C07K16/24

CPC分类号： C07K16/2866 ,  C07K16/247 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/522

摘要： The present invention provides compositions for treating canine atopic dermatitis that comprise a caninized anti-proliferative antibody, a caninized anti-pruritic antibody, and a caninized anti-inflammatory antibody. The present invention further relates to compositions that comprise a bispecific antibody that comprises a caninized anti -pruritic antibody and a caninized anti-proliferative antibody or alternatively a bispecific antibody comprising a caninized anti-pruritic antibody and a caninized anti-inflammatory antibody.

公开(公告)号：US11712416B2

公开(公告)日：2023-08-01

申请号：US17189939

申请日：2021-03-02

申请人： Intervet Inc.

发明人： Keith Freehauf ,  Niki Waldron ,  Jürgen Lutz ,  Frank Guerino

IPC分类号： A61K9/00 ,  A61K31/42 ,  A61K31/7048 ,  A61K31/35 ,  A61K31/422 ,  A61K47/38 ,  A61K47/22 ,  A61K47/16 ,  A61K45/06 ,  A61K47/18 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/51 ,  A61P43/00 ,  A61P33/14 ,  A61P33/00 ,  A61K47/12 ,  A61K31/365 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61K47/44 ,  A61K47/36 ,  A61K47/42

CPC分类号： A61K9/0056 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/2013 ,  A61K9/282 ,  A61K9/4858 ,  A61K9/5015 ,  A61K9/5123 ,  A61K31/35 ,  A61K31/365 ,  A61K31/42 ,  A61K31/422 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61P33/00 ,  A61P33/14 ,  A61P43/00

摘要： A solid oral pharmaceutical composition for delivery of a pharmaceutically acceptable active ingredient to an animal where the composition comprises an isoxazoline compound, a solvent and an excipient, a process for the manufacture of such solid oral pharmaceutical composition and a method of controlling a parasite infection administering such solid oral pharmaceutical composition.

公开(公告)号：US11596687B2

公开(公告)日：2023-03-07

申请号：US16309297

申请日：2017-06-15

申请人： Intervet Inc.

发明人： Stephanie Cook ,  Mohamad Morsey ,  Ian Tarpey ,  Iwan Verstegen ,  Paulus Jacobus Antonius Sondermeijer ,  Paul Vermeij

IPC分类号： A61K39/245 ,  C12N7/00 ,  A61P31/22 ,  A61K39/00

摘要： The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.

公开(公告)号：US20230062746A1

公开(公告)日：2023-03-02

申请号：US17785665

申请日：2020-12-18

申请人： Intervet Inc.

发明人： Christopher D. Kulczar ,  Luke Ryan Schenck ,  Yongjun Li ,  Alfred C.F. Rumondor

IPC分类号： A61K9/20 ,  A61K31/4439 ,  A61P17/00

摘要： A pharmaceutical composition of pyrazole compound dispersed in a polymer matrix and a method of using the same to treat atopic dermatitis.

公开(公告)号：US20230044037A1

公开(公告)日：2023-02-09

申请号：US17785229

申请日：2020-12-18

申请人： Intervet Inc.

发明人： Mohamad Morsey ,  Yuanzheng Zhang

IPC分类号： C07K16/28 ,  A61P17/00 ,  C12N15/85 ,  C12N5/071

摘要： The present invention provides antibodies to canine IL-4 receptor alpha that have a high binding affinity for canine IL-4 receptor alpha, and that can block the binding of canine IL-4 and/or IL-13 to canine IL-4 receptor alpha. The present invention further relates to epitopes of IL-4 receptor alpha that bind to the antibodies to canine IL-4 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.

公开(公告)号：US20220323421A1

公开(公告)日：2022-10-13

申请号：US17628062

申请日：2020-07-21

申请人： Intervet Inc.

发明人： Laura Ann Northrup ,  Keith Freehauf ,  Niki Waldron ,  Timothy Susko

IPC分类号： A61K31/422 ,  A61K9/00 ,  A61K31/42 ,  A61K31/4155 ,  A61K31/365 ,  A61K47/10 ,  A61K47/36 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44

摘要： The present application relates to a soft chewable veterinary dosage form comprising a systemic parasiticide as well as a physiologically active macrocyclic lactone and to a method for preparing said soft chewable veterinary dosage form.

公开(公告)号：US11423679B2

公开(公告)日：2022-08-23

申请号：US16442310

申请日：2019-06-14

申请人： Intervet Inc.

发明人： Pavel Vácha ,  Petr Jankuj ,  Richard Josef Marhoefer ,  Václav Belák ,  Jind{hacek over (r)}ich Soukup ,  Brunhilde Schölzke ,  Britta von Oepen

IPC分类号： G06V20/00 ,  G06V20/69 ,  G06T7/00

摘要： A parasite analysis system includes a pressure vessel configured to store a biological sample, an imaging cell connected to the pressure vessel, and a waste depository connected to the imaging cell. An input valve controls whether biological sample can flow from the pressure vessel into the imaging cell and an output valve controls whether biological sample can flow from the imaging cell into the waste depository. The parasite analysis system also includes a camera that captures a chronological set of images of a portion of the biological sample in the imaging cell and an image analysis system that analyzes the chronological set of images to generate an estimate of a number of parasites in the portion of the biological sample. Estimates for multiple portions of the biological sample may be generated and sampling techniques used to estimate the number of parasites in the entire biological sample.

公开(公告)号：US11406617B2

公开(公告)日：2022-08-09

申请号：US16472084

申请日：2017-12-22

申请人： Intervet Inc.

发明人： Thorsten Meyer ,  Ralf Warrass ,  Joachim Ullrich ,  Michael Berger ,  Michael Linder

IPC分类号： A61K31/27 ,  A61P31/04 ,  A61P11/00 ,  A61K9/00 ,  A61K31/166 ,  A61K31/222 ,  A61K31/357 ,  A61K31/40 ,  A61K31/445 ,  A61K31/472 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/695

摘要： The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20220233675A1

公开(公告)日：2022-07-28

申请号：US17721115

申请日：2022-04-14

申请人： Intervet Inc.

发明人： Maarten Hendrik Witvliet ,  Johanna Jacoba Elisabeth Bijlsma

IPC分类号： A61K39/102

摘要： The present invention pertains to a vaccine to protect a pig against an infection with Actinobacillus pleuropneumoniae, the vaccine comprising an RTX toxin of Actinobacillus pleuropneumoniae recombinantly expressed by a baculovirus, and a pharmaceutically acceptable carrier.