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    DILUENT PREPARATION MODULE
    111.
    发明公开
    DILUENT PREPARATION MODULE 审中-公开

    公开(公告)号：US20240192247A1

    公开(公告)日：2024-06-13

    申请号：US18584136

    申请日：2024-02-22

    Applicant: Beckman Coulter, Inc.

    Inventor： Craig R. Veiner

    IPC: G01N35/10 ,  G01N1/38 ,  G01N33/50 ,  G01N33/53 ,  G01N35/00

    CPC classification number: G01N35/1016 ,  G01N1/38 ,  G01N33/5008 ,  G01N35/1002 ,  G01N2001/383 ,  G01N33/5302 ,  G01N35/00693 ,  G01N2035/1058

    Abstract: Certain types of automated medical analysis equipment are used to analyze blood or other fluids. The equipment may thus use various diluents or reagents that allow the blood or other fluids to be run through the analysis equipment for analysis and data collection. Disclosed is a diluent preparation module that combines purified water and reagent concentrate for use by this equipment. Also disclosed is a diluent preparation unit that combines more than one diluent preparation modules for redundancy and back-up purposes. Also disclosed are systems for supplying the Diluent prepared by the diluent preparation module or diluent preparation unit to one or more analytic instruments.

    Solid state ion selective electrodes
    113.
    发明授权
    Solid state ion selective electrodes 有权

    公开(公告)号：US11994489B2

    公开(公告)日：2024-05-28

    申请号：US17144633

    申请日：2021-01-08

    Applicant: Beckman Coulter, Inc.

    Inventor： John M. Wallach ,  Xihai Mu

    IPC: G01N27/333 ,  G01N33/487

    CPC classification number: G01N27/333 ,  G01N33/48735

    Abstract: An ion selective electrode (“ISE”) assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion.

    CLINICAL LABORATORY AUTOMATION SYSTEM WITH SINGLE CALIBRATOR
    115.
    发明公开
    CLINICAL LABORATORY AUTOMATION SYSTEM WITH SINGLE CALIBRATOR 审中-公开

    公开(公告)号：US20240061001A1

    公开(公告)日：2024-02-22

    申请号：US18269668

    申请日：2021-11-23

    Applicant: Beckman Coulter, Inc. ,  DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Takayuki MIZUTANI ,  Thomas W. ROSCOE ,  John J. BLACKWOOD

    IPC: G01N35/00 ,  G01N35/10

    CPC classification number: G01N35/00693 ,  G01N35/1016 ,  G01N2035/00702

    Abstract: An external calibration curve relies on external calibrators containing known concentrations of a target analyte that can deteriorate over time, leading to inaccurate results. Generating new calibration curves often requires preparing several calibrators to obtain calibration points needed for generating the calibration curves. Preparing the calibrators necessary for multi-point calibration curves requires operator preparation time and can introduce handling errors. The presently claimed and described technology provides a clinical laboratory automation system, including a fluid handling system, an analyzer component, and a mass spectrometer. The clinical laboratory automation system can provide automated calibration using one calibrator to prepare one or more calibrator dilutions used to generate a calibration curve for the quantitative measurement of a target analyte in a sample. The clinical laboratory automation analyzer may also provide an automated evaluation of pipettor dispensing volume and adjustment of the pipettor actuator to deliver an accurate dispensing volume.

    COMPOSITIONS AND METHODS FOR STABLE TRYPAN BLUE SOLUTIONS
    116.
    发明公开
    COMPOSITIONS AND METHODS FOR STABLE TRYPAN BLUE SOLUTIONS 审中-公开

    公开(公告)号：US20240059898A1

    公开(公告)日：2024-02-22

    申请号：US18255761

    申请日：2021-12-03

    Applicant: BECKMAN COULTER, INC.

    Inventor： Alec LUTZKE ,  Blake R. MCCARTY

    IPC: C09B67/44 ,  C09B35/029

    CPC classification number: C09B67/0083 ,  C09B35/029

    Abstract: Compositions, methods, and kits for stable Trypan Blue solutions are provided. In one example, a method includes: cooling a solution of Trypan Blue; and filtering the cooled solution. In another example, a method includes: mixing a water-soluble polymer with a Trypan Blue solution. The method may further include adding one or more ingredients such as an aqueous buffer, an osmolyte, an acid, a base, a buffer, a cell culture medium, water, or combinations thereof.

    HEATED DEGASSING DISPENSER AND METHODS
    117.
    发明公开
    HEATED DEGASSING DISPENSER AND METHODS 审中-公开

    公开(公告)号：US20240053371A1

    公开(公告)日：2024-02-15

    申请号：US18259997

    申请日：2021-12-31

    Applicant: Beckman Coulter, Inc.

    Inventor： Christopher R. Knutson ,  Kevin L. NOWAK ,  Jon P. LINDQUIST, Jr. ,  Gamachu MELKAMU ,  Glenn A. DAVIS

    IPC: G01N35/10

    CPC classification number: G01N35/1002

    Abstract: Disclosed are dispensers (100, 200, 300) and methods for dispensing and degassing a liquid (102). The dispensers and methods may include a heater (308) and a first tube (124, 502) constructed of a first material. The first tube may include a first end (124A) operable to be connected to a source (104) of the liquid and a second end (124B). The first tube may be connected to the heater via a conductive pathway thermally connecting the heater to the first tube. The first material may have a permeability such that a portion of the gas dissolved in the liquid passes through the first material to an atmosphere upon being degassed from a portion of the liquid within the first tube (124, 502).

    Apparatus and method for closing a sample container
    120.
    发明授权
    Apparatus and method for closing a sample container 有权

    公开(公告)号：US11897653B2

    公开(公告)日：2024-02-13

    申请号：US17606395

    申请日：2020-04-22

    Applicant: Beckman Coulter, Inc.

    Inventor： Christoph Bruggaier ,  Diana Illichmann

    IPC: B65B7/28

    CPC classification number: B65B7/2821 ,  B65B7/285

    Abstract: An applicator assembly (100) for closing a sample container (500) with a plug (16) is proposed. The applicator assembly comprises a magazine (102) configured to store a string (10) comprising polymer-based material, an insertion device (104) configured to insert an end piece (12) of the string at least partly into an opening (502) of the sample container (500), and a drive system (106) configured to supply at least a part of the string (10) from the magazine (102) to the insertion device (104). The applicator assembly further comprises a separator (108) configured to separate the end piece (12) from the string, such that the end piece (12) forms a plug (16) closing the sample container (500).

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