公开(公告)号：US20200247754A1

公开(公告)日：2020-08-06

申请号：US16341595

申请日：2017-10-09

Applicant: Michael T. RUDD ,  Zhaoyang MENG ,  Jenny WAI ,  David Jonathan BENNETT ,  Edward J. BRNARDIC ,  Nigel J. LIVERTON ,  Shawn J. STACHEL ,  Yongxin HAN ,  Paul TEMPEST ,  Jiuxiang ZHU ,  Xuewang XU ,  Bin ZHU ,  Merck Sharp & Dohme Corp.

Inventor： Michael T. Rudd ,  Zhaoyang Meng ,  Jenny Wai ,  David Jonathan Bennett ,  Edward J. Brnardic ,  Nigel J. Liverton ,  Shawn J. Stachel ,  Yongxin Han ,  Paul Tempest ,  Jiuxiang Zhu ,  Xuewang Xu ,  Bin Zhu

IPC: C07D221/20 ,  C07D401/12 ,  C07D417/12 ,  C07D405/12 ,  C07D211/22 ,  C07D401/14 ,  C07D417/14

Abstract: In its many embodiments, the present invention provides certain substituted aryl and heteroaryl ether compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

公开(公告)号：US20160335932A1

公开(公告)日：2016-11-17

申请号：US15219951

申请日：2016-07-26

Applicant: Jorge Perez-Bravo ,  QINGHUA XIAO ,  BIN ZHU

Inventor： Jorge Perez-Bravo ,  QINGHUA XIAO ,  BIN ZHU

IPC: G09F9/302 ,  F21V21/096 ,  G09F13/00 ,  F21V21/30 ,  G09F7/20 ,  G09F9/30

CPC classification number: G09F9/3026 ,  F21S8/033 ,  F21S8/036 ,  F21V21/02 ,  F21V21/096 ,  F21V21/22 ,  F21V21/30 ,  F21V21/34 ,  F21Y2105/00 ,  G09F7/18 ,  G09F7/20 ,  G09F9/301 ,  G09F13/00 ,  G09F13/04 ,  G09F19/226 ,  G09F2007/1852 ,  Y10T29/49826 ,  Y10T29/4984

Abstract: Display module mounting apparatus and methods provide mounting features enabling ease of installation and service. The apparatus may have one or more releasable frame couplers and pivoting releasable frame couplers coupled to a display module having a display plane defined in relation to a substrate. One or more adjustable linkages may adjustably define a standoff distance between the display plane and a support frame to which the module may be mounted by the mounting apparatus. Concave and convex adjustments to the display plane may be made. Operation of pivoting action to tilt the display plane enables installation, removal, and serviceability of large displays constructed with a tiled plurality of display modules.

Abstract translation: 显示模块安装装置和方法提供安装特征，使安装和维修变得容易。 该装置可以具有一个或多个可释放的框架耦合器和枢转的可释放的框架耦合器，其耦合到具有相对于衬底限定的显示平面的显示模块。 一个或多个可调节联动装置可以可调整地限定显示平面与支撑框架之间的间隔距离，该模块可由该安装装置安装到支撑框架上。 可以对显示平面进行凹凸调整。 使显示平面倾斜的枢转动作的操作使得能够利用平铺的多个显示模块构建的大型显示器的安装，移除和可使用性。

公开(公告)号：US09404644B1

公开(公告)日：2016-08-02

申请号：US15010593

申请日：2016-01-29

Applicant: Jorge Perez-Bravo ,  Qinghua Xiao ,  Bin Zhu

Inventor： Jorge Perez-Bravo ,  Qinghua Xiao ,  Bin Zhu

IPC: F21V21/30 ,  F21V21/34 ,  F21V21/02 ,  F21V21/22 ,  F21V21/096 ,  G09F13/04 ,  G09F9/30 ,  G09F19/22 ,  G09F7/18 ,  G09F7/20 ,  G09F15/00 ,  F21S8/00 ,  F21Y105/00 ,  G09F9/302

CPC classification number: G09F9/3026 ,  F21S8/033 ,  F21S8/036 ,  F21V21/02 ,  F21V21/096 ,  F21V21/22 ,  F21V21/30 ,  F21V21/34 ,  F21Y2105/00 ,  G09F7/18 ,  G09F7/20 ,  G09F9/301 ,  G09F13/00 ,  G09F13/04 ,  G09F19/226 ,  G09F2007/1852 ,  Y10T29/49826 ,  Y10T29/4984

Abstract: Display module mounting apparatus and methods provide mounting features enabling ease of installation and service. The apparatus may have one or more releasable frame couplers and pivoting releasable frame couplers coupled to a display module having a display plane defined in relation to a substrate. One or more adjustable linkages may adjustably define a standoff distance between the display plane and a support frame to which the module may be mounted by the mounting apparatus. Concave and convex adjustments to the display plane may be made. Operation of pivoting action to tilt the display plane enables installation, removal, and serviceability of large displays constructed with a tiled plurality of display modules.

公开(公告)号：US08859791B2

公开(公告)日：2014-10-14

申请号：US13878659

申请日：2011-10-11

Applicant: Hua Li ,  Min Lin ,  Xiaoju Wu ,  Wei Wang ,  Chijian He ,  Jizao Gao ,  Xingtian Shu ,  Shuanghua Wan ,  Bin Zhu

Inventor： Hua Li ,  Min Lin ,  Xiaoju Wu ,  Wei Wang ,  Chijian He ,  Jizao Gao ,  Xingtian Shu ,  Shuanghua Wan ,  Bin Zhu

IPC: C07D301/12 ,  C07D303/04

CPC classification number: C07D301/12 ,  C07D303/04

Abstract: A process for producing an alkylene oxide by olefin epoxidation, wherein said process comprises the steps of: (1) in a first olefin epoxidation condition, in the presence of a first solid catalyst, a first mixed stream containing a solvent, an olefin and H2O2 is subjected to an epoxidation in one or more fixed bed reactors and/or one or more moving bed reactors until the conversion of H2O2 reaches 50%-95%, then, optionally, the resulting reaction mixture obtained in the step (1) is subjected to a separation to obtain a first stream free of H2O2 and a second stream containing the unreacted H2O2, and the olefin is introduced to the second stream to produce a second mixed stream, or optionally, the olefin is introduced to the reaction mixture obtained in the step (1) to produce a second mixed stream; (2) in a second olefin epoxidation condition, the reaction mixture obtained in the step (1) or the second mixed stream obtained in the step (1) and a second solid catalyst are introduced to one or more slurry bed reactors to conduct an epoxidation until the total conversion of H2O2 reaches 98% or more, with a proviso that said process for producing the alkylene oxide by olefin epoxidation has an selectivity for the alkylene oxide of 90% or more.The process of the present invention combines the slurry bed reactor with the fixed bed reactor and/or the moving bed reactor so as to overcome the disadvantages of the low conversion of H2O2 in the case that only the fixed bed reactor and/or the moving bed reactor are used, and the low selectivity for the target alkylene oxide in the case that only the slurry bed reactor is used.

Abstract translation: 一种通过烯烃环氧化生产烯化氧的方法，其中所述方法包括以下步骤：（1）在第一烯烃环氧化条件下，在第一固体催化剂存在下，将含有溶剂，烯烃和H 2 O 2的第一混合物流 在一个或多个固定床反应器和/或一个或多个移动床反应器中进行环氧化，直到H 2 O 2的转化率达到50％-95％，然后，任选地，将在步骤（1）中获得的所得反应混合物 以分离以获得不含H 2 O 2的第一物流和含有未反应的H 2 O 2的第二物流，并将烯烃引入第二物流以产生第二混合物流，或任选地将烯烃引入到 步骤（1）以产生第二混合流; （2）在第二烯烃环氧化条件下，将步骤（1）中获得的反应混合物或步骤（1）中获得的第二混合物流和第二固体催化剂引入一个或多个淤浆床反应器中进行环氧化 直到H 2 O 2的总转化率达到98％以上，条件是通过烯烃环氧化生产环氧烷烃的方法对环氧烷烃的选择性为90％以上。 本发明的方法将淤浆床反应器与固定床反应器和/或移动床反应器结合，以克服在只有固定床反应器和/或移动床的情况下H 2 O 2转化率低的缺点 使用反应器，在仅使用浆料床反应器的情况下对目标烯化氧的选择性低。

公开(公告)号：US20140128428A1

公开(公告)日：2014-05-08

申请号：US14152006

申请日：2014-01-10

Applicant: Raymond W. Colburn ,  Scott L. Dax ,  Christopher M. Flores ,  Donald W. Ludovici ,  Mingde Xia ,  Xiaoqing Xu ,  Mark A. Youngman ,  Bin Zhu

Inventor： Raymond W. Colburn ,  Scott L. Dax ,  Christopher M. Flores ,  Donald W. Ludovici ,  Mingde Xia ,  Xiaoqing Xu ,  Mark A. Youngman ,  Bin Zhu

IPC: C07D217/04

CPC classification number: C07D217/04 ,  C07C237/20 ,  C07C2102/08 ,  C07C2602/08 ,  C07D215/38 ,  C07D217/02 ,  C07D401/12

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined herein.

Abstract translation: 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中A，L，R 1，R 2，R 4和R 5在本文中定义。

公开(公告)号：US08595011B2

公开(公告)日：2013-11-26

申请号：US12167707

申请日：2008-07-03

Applicant: Qin Shi ,  Wei Zhang ,  Wei Bin Zhu ,  Hai Xin Chai

Inventor： Qin Shi ,  Wei Zhang ,  Wei Bin Zhu ,  Hai Xin Chai

IPC: G10L17/00

CPC classification number: G10L13/10 ,  G10L21/04

Abstract: The present invention provides a method and apparatus for text to speech conversion, and a method and apparatus for adjusting a corpus. The method for text to speech comprises: text analysis step for parsing the text to obtain descriptive prosody annotations of the text based on a TTS model generated from a first corpus; prosody parameter prediction step for predicting the prosody parameter of the text according to the result of text analysis step; speech synthesis step for synthesizing speech of said text based on said the prosody parameter of the text; wherein descriptive prosody annotations of the text include prosody structure for the text, the prosody structure of the text is adjusted according to a target speech speed for the synthesized speech. The present invention adjusts the prosody structure of the text according to the target speech speed. The synthesized speech will have improved quality.

Abstract translation: 本发明提供了一种用于文本到语音转换的方法和装置，以及用于调整语料库的方法和装置。 文本到语音的方法包括：文本分析步骤，用于解析文本，以基于从第一语料库生成的TTS模型来获得文本的描述性韵律注释; 韵律参数预测步骤，根据文本分析步骤的结果预测文本的韵律参数; 基于所述文本的韵律参数来合成所述文本的语音的语音合成步骤; 其中文本的描述性韵律注释包括文本的韵律结构，根据合成语音的目标言语速度来调整文本的韵律结构。 本发明根据目标语音速度来调整文本的韵律结构。 综合演讲将提高质量。

公开(公告)号：US08362000B2

公开(公告)日：2013-01-29

申请号：US12765420

申请日：2010-04-22

Applicant: Haiyan Bian ,  Kristen Chevalier ,  Jose Clemente ,  Pete Connolly ,  Chris Flores ,  Shu-Chen Lin ,  Li Liu ,  John Mabus ,  Mark Macielag ,  Mark McDonnell ,  Philip Pitis ,  Yue-Mei Zhang ,  Sui-Po Zhang ,  Bin Zhu

Inventor： Haiyan Bian ,  Kristen Chevalier ,  Jose Clemente ,  Pete Connolly ,  Chris Flores ,  Shu-Chen Lin ,  Li Liu ,  John Mabus ,  Mark Macielag ,  Mark McDonnell ,  Philip Pitis ,  Yue-Mei Zhang ,  Sui-Po Zhang ,  Bin Zhu

IPC: A61K31/496 ,  A61K31/5377 ,  C07D205/04 ,  C07D401/12 ,  C07D403/04 ,  C07D409/06 ,  C07D413/12

CPC classification number: C07D403/10 ,  C07D205/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.

公开(公告)号：US08349756B2

公开(公告)日：2013-01-08

申请号：US12594008

申请日：2008-03-27

Applicant: Min Lin ,  Chunfeng Shi ,  Jun Long ,  Bin Zhu ,  Xingtian Shu ,  Xuhong Mu ,  Yibin Luo ,  Xieqing Wang ,  Yingchun Ru

Inventor： Min Lin ,  Chunfeng Shi ,  Jun Long ,  Bin Zhu ,  Xingtian Shu ,  Xuhong Mu ,  Yibin Luo ,  Xieqing Wang ,  Yingchun Ru

IPC: B01J29/89

CPC classification number: B01J35/002 ,  B01J23/38 ,  B01J23/40 ,  B01J23/44 ,  B01J29/89 ,  B01J35/0046 ,  B01J35/006 ,  B01J2229/20 ,  C07D301/08 ,  Y02P20/52

Abstract: A noble metal-containing titanosilicate material, characterized in that said material is represented with the oxide form of xTiO2.100SiO2.yEOm.zE, wherein x ranges from 0.001 to 50.0; (y+z) ranges from 0.0001 to 20.0 and y/z

Abstract translation: 一种含贵金属的钛硅酸盐材料，其特征在于，所述材料用xTiO2.1··O·SiO 2·yO·m·zE的氧化物形式表示，其中x为0.001-50.0; （y + z）为0.0001〜20.0，y / z <5。 E表示选自Ru，Rh，Pd，Re，Os，Ir，Pt，Ag和Au中的一种或多种贵金属; m是满足E的氧化态的数。所述材料的晶粒含有中空结构或下垂结构。 在所述材料中，增强了贵金属和钛硅酸盐之间的协同效应。 与现有技术相比，在氧化反应中，反应产物的选择性，催化活性和稳定性明显增加。 通过丙烯环氧化制备环氧丙烷的反应。

公开(公告)号：US20120183953A1

公开(公告)日：2012-07-19

申请号：US13096408

申请日：2011-04-28

Applicant: Nianqing XIAO ,  John K. HENKHAUS ,  Bin ZHU ,  Deacon SWEENEY ,  Thomas ANANTHARAMAN ,  Ryan PTASHKIN

Inventor： Nianqing XIAO ,  John K. HENKHAUS ,  Bin ZHU ,  Deacon SWEENEY ,  Thomas ANANTHARAMAN ,  Ryan PTASHKIN

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6869 ,  C12Q2521/301 ,  C12Q2523/31 ,  C12Q2565/601

Abstract: The invention generally relates to methods for assembling sequence contigs. In certain embodiments, methods of the invention involve converting sequence contigs into maps, generating a plurality of single molecule restriction maps, aligning single molecule restriction maps to ends of the maps of the sequence contigs, thereby producing extended sequence contigs, and aligning extended sequence contigs.

Abstract translation: 本发明一般涉及组装序列重叠群的方法。 在某些实施方案中，本发明的方法涉及将序列重叠群转化为图，产生多个单分子限制性图谱，将单分子限制图谱对准序列重叠群的图的末端，从而产生扩增序列重叠群，并对齐扩增序列重叠群 。

公开(公告)号：US08131007B2

公开(公告)日：2012-03-06

申请号：US11929137

申请日：2007-10-30

Applicant: Ahmed Tewfik ,  Bin Zhu ,  Mitch Swanson

Inventor： Ahmed Tewfik ,  Bin Zhu ,  Mitch Swanson

IPC: H04K1/00

CPC classification number: G06T1/0071 ,  G06T2201/0081 ,  G06T2201/0083 ,  G10L19/018 ,  H04N1/32144 ,  H04N1/32165 ,  H04N1/3217 ,  H04N1/32192 ,  H04N1/32304 ,  H04N5/782 ,  H04N5/913 ,  H04N9/804 ,  H04N19/467 ,  H04N21/23892 ,  H04N21/8358 ,  H04N2005/91335 ,  H04N2201/3233 ,  H04N2201/3236 ,  H04N2201/3239 ,  H04N2201/327

Abstract: A method of embedding a watermarking in a host signal computes a first watermark depending on a particular party and computes a second watermark depending on the host signal. The method embeds the first and second watermarks in the host signal. At least one of the watermarks is embedded using a key derived from the host signal. In particular, one of the watermarks is embedded with a key derived from the host signal.

Abstract translation: 在主机信号中嵌入水印的方法根据特定方式计算第一水印，并根据主机信号计算第二水印。 该方法将第一和第二水印嵌入主机信号。 使用从主机信号导出的密钥来嵌入至少一个水印。 特别地，其中一个水印嵌入了从主机信号导出的密钥。