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公开(公告)号：US20240244354A1
公开(公告)日：2024-07-18
申请号：US18561985
申请日：2022-05-20
Applicant: Massachusetts Institute of Technology
Inventor： Manya Ghobadi , Zhizhen Zhong , Weiyang Wang , Liane Sarah Beland Bernstein , Alexander Sludds , Ryan HAMERLY , Dirk Robert ENGLUND
IPC: H04Q11/00 , G06N5/04 , H04B10/524
CPC classification number: H04Q11/0005 , G06N5/04 , H04B10/524 , H04Q2011/0039 , H04Q2011/0041
Abstract: In-network Optical Inference (IOI) provides low-latency machine learning inference by leveraging programmable switches and optical matrix multiplication. IOI uses a transceiver module, called a Neuro Transceiver, with an optical processor to perform linear operations, such as matrix multiplication, in the optical domain. IOI's transceiver modules can be plugged into programmable packet switches, which are programmed to perform non-linear activations in the electronic domain and to respond to inference queries. Processing inference queries at the programmable packet switches inside the network, without sending them to cloud or edge inference servers, significantly reduces end-to-end inference latency experienced by users.
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公开(公告)号：US12038608B2
公开(公告)日：2024-07-16
申请号：US17470803
申请日：2021-09-09
Applicant: Massachusetts Institute of Technology
Inventor： Saumil Bandyopadhyay , Dirk Robert Englund
CPC classification number: G02B6/125 , G02B2006/12147
Abstract: The next-generation of optoelectronic systems will require efficient optical signal transfer between many discrete photonic components integrated onto a single substrate. While modern assembly processes can easily integrate thousands of electrical components onto a single board, photonic assembly is far more challenging due to the wavelength-scale alignment tolerances required. Here we address this problem by introducing a self-aligning photonic coupler insensitive to x, y, z displacement and angular misalignment. The self-aligning coupler provides a translationally invariant evanescent interaction between waveguides by intersecting them at an angle, which enables a lateral and angular alignment tolerance fundamentally larger than non-evanescent approaches such as edge coupling. This technology can function as a universal photonic connector interfacing photonic integrated circuits and microchiplets across different platforms. For example, it can be used in a self-aligning photonic circuit board that can be assembled more easily, with larger misalignment tolerances, than other complex optoelectronic systems.
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公开(公告)号：US12036240B2
公开(公告)日：2024-07-16
申请号：US16442348
申请日：2019-06-14
Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
Inventor： Aviv Regev , Ana Carrizosa Anderson , Ayshwarya Subramanian , Orit Rozenblatt-Rosen
IPC: C12N5/00 , A61K35/17 , C07K14/705 , C07K14/725 , G01N33/50 , C07K16/28
CPC classification number: A61K35/17 , C07K14/7051 , C07K14/70596 , C07K16/2818 , C07K16/2827
Abstract: This invention relates generally to compositions and methods for modulating complement component 3 (C3) activity or expression to treat, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells.
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公开(公告)号：US20240236451A1
公开(公告)日：2024-07-11
申请号：US18405303
申请日：2024-01-05
Applicant: Massachusetts Institute of Technology
Inventor： Gregory Cappiello , George Turner , Brian Edwards , Emma Landsiedel , Ryan Little
CPC classification number: H04N23/51 , B63G8/001 , H04N23/12 , H04N23/57 , H04N23/64 , B63G2008/004 , G02B7/182 , G02B27/0012
Abstract: According to some embodiments, a pressure tolerant camera system includes: an enclosure filled with an incompressible fluid and having a viewport through which light can pass; a digital image sensor provided within the enclosure; and a plurality of mirror lenses provided within the enclosure and arranged to reflect light from the viewport onto the digital image sensor.
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公开(公告)号：US20240230627A1
公开(公告)日：2024-07-11
申请号：US18458657
申请日：2023-08-30
Applicant: Massachusetts Institute of Technology
Inventor： Michael Birnbaum , Connor Dobson
IPC: G01N33/50 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/705 , C07K14/74 , C07K16/28 , C12N15/86
CPC classification number: G01N33/505 , C07K14/005 , C07K14/4748 , C07K14/5437 , C07K14/70532 , C07K14/70539 , C07K16/2803 , C12N15/86 , C07K2317/622 , C07K2319/02 , C07K2319/035 , C07K2319/60 , C12N2740/15045
Abstract: Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
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Patent Agency Ranking
公开(公告)号：US20240229020A9
公开(公告)日：2024-07-11
申请号：US18343768
申请日：2023-06-29
Applicant: Massachusetts Institute of Technology
Inventor： Nayan Agarwal , Ashwin Gopinath , Emily Wu
CPC classification number: C12N15/11 , B01J19/0046 , B01J2219/00722
Abstract: Provided herein are inorganic nucleic acid supramolecular structures and methods for making them. In certain aspects, the construct includes a structured nucleic acid polymer micelle, which micelle includes a structured nucleic acid template; one or more functional moieties attached to the template; and polymers that interact with nucleic acid present in the template to form the structured nucleic acid polymer micelle; and an inorganic shell surrounding the structured nucleic acid template, in which the one or more functional moieties extend outside the structured nucleic acid polymer micelle and the inorganic shell to maintain functionality.
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公开(公告)号：US20240229014A1
公开(公告)日：2024-07-11
申请号：US18408191
申请日：2024-01-09
Applicant: Massachusetts Institute of Technology
Inventor： Emma J. Chory , Kevin Esvelt , Vainavi Mukkamala
IPC: C12N15/10
CPC classification number: C12N15/1058 , C12N15/1055 , C12N15/1086
Abstract: The invention, in part, includes systems and methods for conducting and optimizing continuous evolution of molecules capable of forming multi-body complexes, such as but not limited to evolution of molecules capable of forming three- and four-molecule multi-body complexes.
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公开(公告)号：US20240222935A1
公开(公告)日：2024-07-04
申请号：US17905806
申请日：2021-03-12
Inventor： Seok-Hyun Yun , Paul Dannenberg
IPC: H01S5/10
CPC classification number: H01S5/1075 , H01S5/1042 , H01S2301/18
Abstract: A laser microparticle for generating laser light with high omnidirectionality, including: an optical cavity including an active gain material capable of supporting one or more lasing cavity modes: and an optical scattering element which is incorporated into the optical cavity and configured to change a radiation pattern of the one or more lasing cavity modes to increase omnidirectionality of the radiation pattern, the size of the microparticle being less than 10 pm in each dimension.
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公开(公告)号：US20240218334A1
公开(公告)日：2024-07-04
申请号：US18432439
申请日：2024-02-05
Inventor： Alessio Fasano , Timothy K. Lu , Stefania Senger , Maria Eugenia Inda
CPC classification number: C12N5/0679 , G01N33/5044 , G01N33/6803 , C12N2501/998 , C12N2503/02 , C12N2506/03 , C12N2513/00 , G01N2500/10
Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
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公开(公告)号：US12024445B2
公开(公告)日：2024-07-02
申请号：US18086456
申请日：2022-12-21
Applicant: Massachusetts Institute of Technology
Inventor： Trevor Alan Hatton , Xianwen Mao , Yinying Ren
IPC: C25B9/17 , C02F1/28 , C02F1/461 , C02F1/469 , C02F101/30 , C02F101/34 , C02F101/36
CPC classification number: C02F1/46109 , C02F1/285 , C02F1/46104 , C02F1/469 , C25B9/17 , C02F2001/46138 , C02F2101/306 , C02F2101/308 , C02F2101/34 , C02F2101/36 , C02F2303/16
Abstract: An asymmetric system containing a first conductive polymer modified with a redox active moiety and a second conductive polymer modified with a surfactant is used for the separation of organic compounds from aqueous solutions. The asymmetric system has complementary hydrophobicity tunability in response to electrochemical modulations. For example, both materials are hydrophobic in their respective neutral states, therefore exhibiting affinity toward organic compounds. Application of a mild potential drives the desorption of the organic compounds and regeneration of the materials. The asymmetric system can be used in a cyclic fashion, through repeated electrical discharge or shorting of the two electrodes to program the capture of organics from a feed solution, and application of a potential to stimulate the release of the adsorbed organics.
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