公开(公告)号：US20200085356A1

公开(公告)日：2020-03-19

申请号：US16691325

申请日：2019-11-21

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, JR. ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1473

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

公开(公告)号：US20190320955A1

公开(公告)日：2019-10-24

申请号：US16457693

申请日：2019-06-28

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, JR. ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/1473

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

公开(公告)号：US20190320954A1

公开(公告)日：2019-10-24

申请号：US16457692

申请日：2019-06-28

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, JR. ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/1473

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

公开(公告)号：US20190209095A1

公开(公告)日：2019-07-11

申请号：US16356599

申请日：2019-03-18

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  James H. Brauker ,  Aarthi Mahalingam ,  Ying Li

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/01

CPC classification number: A61B5/7203 ,  A61B5/01 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7225 ,  A61B5/7239 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/742 ,  A61B2560/0252 ,  Y02A90/22 ,  Y02A90/26

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

公开(公告)号：US10327638B2

公开(公告)日：2019-06-25

申请号：US15798097

申请日：2017-10-30

Applicant: DexCom, Inc.

Inventor： Mark C. Brister ,  Paul V. Neale ,  Peter C. Simpson ,  James H. Brauker ,  James Patrick Thrower ,  Mark Shults ,  Rathbun K. Rhodes ,  Paul V. Goode, Jr. ,  Arnold L. Holmquist

IPC: A61B5/1473 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  H04B1/03

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

公开(公告)号：US20190110724A1

公开(公告)日：2019-04-18

申请号：US16222804

申请日：2018-12-17

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR.

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/145

Abstract: Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US20180289333A1

公开(公告)日：2018-10-11

申请号：US16000748

申请日：2018-06-05

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Ying Li ,  Mohammad Ali Shariati ,  James H. Brauker ,  Mark C. Brister ,  Robert Boock

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/01

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.

公开(公告)号：US20180256084A1

公开(公告)日：2018-09-13

申请号：US15977927

申请日：2018-05-11

Applicant: DexCom, Inc.

Inventor： James R. Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

IPC: A61B5/1473 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006

Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

公开(公告)号：US20170340253A1

公开(公告)日：2017-11-30

申请号：US15680053

申请日：2017-08-17

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR.

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/145 ,  B33Y70/00 ,  B33Y80/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/742 ,  A61B2560/0223 ,  B33Y70/00 ,  B33Y80/00

Abstract: Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US09804114B2

公开(公告)日：2017-10-31

申请号：US15059086

申请日：2016-03-02

Applicant: DexCom, Inc.

Inventor： Rathbun K. Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

IPC: A61B5/05 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  C12Q1/00 ,  G01N33/487

CPC classification number: G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.