公开(公告)号：US09220710B2

公开(公告)日：2015-12-29

申请号：US14151746

申请日：2014-01-09

Applicant: Gilead Sciences, Inc.

Inventor： Steven S. Bondy ,  Carina E. Cannizzaro ,  Chien-Hung Chou ,  John O. Link ,  Qi Liu ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  A61K31/437 ,  C07D471/04 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K45/06

CPC classification number: A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式I化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US20150141353A1

公开(公告)日：2015-05-21

申请号：US14513900

申请日：2014-10-14

Applicant: GILEAD SCIENCES, INC.

Inventor： William E. Delaney, IV ,  John O. Link ,  Hongmei Mo ,  David W. Oldach ,  Adrian S. Ray ,  William J. Watkins ,  Cheng Yong Yang ,  Weidong Zhong

IPC: A61K31/4184 ,  A61K31/381 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/706 ,  A61K31/675

CPC classification number: A61K38/05 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4353 ,  A61K31/4436 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/662 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7068 ,  A61K38/212 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract translation: 本发明涉及可用于治疗丙型肝炎病毒感染的治疗分子的组合。 本发明涉及方法，用途，给药方案和组合物。

公开(公告)号：US20150111891A1

公开(公告)日：2015-04-23

申请号：US14370466

申请日：2013-01-03

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Hongyan Guo ,  Paul Hrvatin ,  Eric Lansdon ,  John O. Link ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Randall W. Vivian ,  Lianhong Xu ,  Hong Yang

IPC: C07D491/06 ,  A61K45/06 ,  C07C59/64 ,  A61K31/192 ,  C07D213/55 ,  A61K31/5377 ,  A61K31/4406 ,  A61K31/4409 ,  C07D277/30 ,  A61K31/426 ,  A61K31/506 ,  A61K31/436 ,  A61K31/4402

CPC classification number: C07D491/06 ,  A61K31/192 ,  A61K31/426 ,  A61K31/436 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07C59/64 ,  C07D213/55 ,  C07D231/56 ,  C07D277/30 ,  C07D277/34 ,  C07D491/04

Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。

公开(公告)号：US20150080569A1

公开(公告)日：2015-03-19

申请号：US14312612

申请日：2014-06-23

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Michael O'Neil Hanrahan Clarke ,  Choung U. Kim ,  John O. Link ,  Hyung-Jung Pyun ,  Xiaoning C. Sheng ,  Qiaoyin Wu

IPC: C07D417/14 ,  C07D207/16

CPC classification number: C07D417/14 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/0819 ,  C07K5/0821

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130177530A1

公开(公告)日：2013-07-11

申请号：US13783056

申请日：2013-03-01

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  Evan S. Krygowski ,  John O. Link ,  James Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang ,  Sheila Zipfel

IPC: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K45/06 ,  A61K38/21

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/06 ,  A61K38/07 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D405/12 ,  C07F5/025 ,  Y10S514/894 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.