公开(公告)号：US20190255085A1

公开(公告)日：2019-08-22

申请号：US16265016

申请日：2019-02-01

Applicant: GILEAD SCIENCES, INC.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US20170088576A1

公开(公告)日：2017-03-30

申请号：US15254684

申请日：2016-09-01

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07H19/16

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20170071964A1

公开(公告)日：2017-03-16

申请号：US15267433

申请日：2016-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K45/06

CPC classification number: A61K31/706 ,  A61K31/7056 ,  A61K2300/00

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Abstract translation: 其中核苷糖的1'位置被取代。 提供的化合物，组合物和方法特别可用于治疗Lassa病毒和Junin病毒感染。

公开(公告)号：US20150141353A1

公开(公告)日：2015-05-21

申请号：US14513900

申请日：2014-10-14

Applicant: GILEAD SCIENCES, INC.

Inventor： William E. Delaney, IV ,  John O. Link ,  Hongmei Mo ,  David W. Oldach ,  Adrian S. Ray ,  William J. Watkins ,  Cheng Yong Yang ,  Weidong Zhong

IPC: A61K31/4184 ,  A61K31/381 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/706 ,  A61K31/675

CPC classification number: A61K38/05 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4353 ,  A61K31/4436 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/662 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7068 ,  A61K38/212 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract translation: 本发明涉及可用于治疗丙型肝炎病毒感染的治疗分子的组合。 本发明涉及方法，用途，给药方案和组合物。

公开(公告)号：US08871785B2

公开(公告)日：2014-10-28

申请号：US13848593

申请日：2013-03-21

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Carina E. Cannizzaro ,  James M. Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee S. Chong ,  Maria Fardis ,  Haolun Jin ,  Ralph Hirschmann ,  Alan X. Huang ,  Choung U. Kim ,  Thorsten A. Kirschberg ,  Christopher P. Lee ,  William A. Lee ,  Richard L. Mackman ,  David Y. Markevitch ,  David A. Oare ,  Vidya K. Prasad ,  Hyung-Jung Pyun ,  Adrian S. Ray ,  Rosemarie O'Shea ,  Sundaramoorthi Swaninathan ,  William J. Watkins ,  Jennifer R. Zhang

IPC: A61K31/44 ,  C07D239/00

CPC classification number: C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/58 ,  C07F9/60 ,  C07F9/65031 ,  C07F9/650905 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US11963961B2

公开(公告)日：2024-04-23

申请号：US17204835

申请日：2021-03-17

Applicant: Gilead Sciences, Inc.

Inventor： Jamie Geier Bates ,  Adrian S. Ray

IPC: A61K31/519 ,  A61K31/216 ,  A61P1/16

CPC classification number: A61K31/519 ,  A61K31/216 ,  A61P1/16 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/216 ,  A61K2300/00

Abstract: The present disclosure provides methods and compositions for treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease.

公开(公告)号：US11492353B2

公开(公告)日：2022-11-08

申请号：US16879491

申请日：2020-05-20

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US20210061806A1

公开(公告)日：2021-03-04

申请号：US16879491

申请日：2020-05-20

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US10696679B2

公开(公告)日：2020-06-30

申请号：US16042085

申请日：2018-07-23

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07F9/6561 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US10251904B2

公开(公告)日：2019-04-09

申请号：US15267433

申请日：2016-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.