公开(公告)号：US20070224663A1

公开(公告)日：2007-09-27

申请号：US11689173

申请日：2007-03-21

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/47

CPC分类号： G01N33/68 ,  A61K38/00 ,  C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070160603A1

公开(公告)日：2007-07-12

申请号：US11614212

申请日：2006-12-21

申请人： Steven Ruben

发明人： Steven Ruben

IPC分类号： A61K39/395 ,  C07K16/30 ,  C12P21/08

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to Tumor Necrosis Factor Delta (TNF-delta; APRIL). The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, treating, preventing, or ameliorating a disease or disorder associated with aberrant APRIL or APRIL receptor expression or aberrant function of APRIL or APRIL receptor, comprising antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to APRIL. In particular, the present invention further relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating autoimmune diseases or disorder, such as systemic lupus erythematosus Rheumatoid arthritis, and Sjögren's syndrome, or cancers of the immune system, particularly B cell cancers such as non-Hodgkin's lymphoma and multiple myeloma, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to APRIL.

摘要翻译： 本发明涉及免疫特异性结合肿瘤坏死因子三角（TNF-δ; APRIL）的抗体和相关分子。 本发明还涉及用于检测，诊断，预后，治疗，预防或改善与APRIL或APRIL受体的异常APRIL或APRIL受体表达或异常功能相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体 ，或与APRIL免疫特异性结合的相关分子。 特别地，本发明还涉及用于检测，诊断，预后，预防，治疗或改善自身免疫性疾病或病症的系统和组合物，例如系统性红斑狼疮类风湿性关节炎和Sjögren综合征，或免疫系统的癌症，特别是B 细胞癌例如非霍奇金淋巴瘤和多发性骨髓瘤，包括向动物，优选人类施用有效量的一种或多种免疫特异性结合APRIL的抗体或其片段或变体或相关分子。

公开(公告)号：US20070154474A1

公开(公告)日：2007-07-05

申请号：US11456261

申请日：2006-07-10

申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

IPC分类号： A61K39/395 ,  C12Q1/68 ,  C12P21/06 ,  C07K14/72 ,  C07H21/04

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

公开(公告)号：US20070055056A1

公开(公告)日：2007-03-08

申请号：US10664357

申请日：2003-09-20

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/72 ,  C07K14/62 ,  C07K16/26

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diabetes mellitus and/or conditions related to diabetes. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与糖尿病相关的糖尿病和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070037206A1

公开(公告)日：2007-02-15

申请号：US10100683

申请日：2002-03-19

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： A61K38/17 ,  G01N33/53 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/5058 ,  G01N33/5064 ,  G01N33/5088 ,  G01N33/68

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

公开(公告)号：US20070026454A1

公开(公告)日：2007-02-01

申请号：US10472965

申请日：2002-03-26

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating hematopoietic and hematologic diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗造血和血液疾病，病症和/或与之相关的病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070015271A1

公开(公告)日：2007-01-18

申请号：US10405027

申请日：2003-04-02

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12N1/12 ,  C12N1/20

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

公开(公告)号：US20070009521A1

公开(公告)日：2007-01-11

申请号：US11517438

申请日：2006-09-08

申请人： Steven Ruben ,  David Hilbert

发明人： Steven Ruben ,  David Hilbert

IPC分类号： A61K39/395 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/74 ,  C07K16/22

CPC分类号： G01N33/6863 ,  G01N2333/715 ,  G01N2500/02 ,  G01N2800/101

摘要： The present invention relates to TR21 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR21 protein. TR21 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR21 activity.

摘要翻译： 本发明涉及TR21多肽。 特别地，提供编码人TR21蛋白的分离的核酸分子。 还提供TR21多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定TR21活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20060281095A1

公开(公告)日：2006-12-14

申请号：US11002754

申请日：2004-12-03

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：US20060003380A1

公开(公告)日：2006-01-05

申请号：US11221849

申请日：2005-09-09

申请人： Steven Ruben ,  Kevin Baker

发明人： Steven Ruben ,  Kevin Baker

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/715 ,  C07K16/28

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。