公开(公告)号：US10508077B2

公开(公告)日：2019-12-17

申请号：US16387937

申请日：2019-04-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, Jr. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/4439 ,  C07D417/04 ,  A61K31/495 ,  C07D241/08 ,  A61K31/44 ,  C07D213/56 ,  A61K31/417 ,  C07D233/68 ,  A61K31/4184 ,  C07D235/14 ,  A61K31/397 ,  A61K31/407 ,  C07D487/10 ,  A61K31/435 ,  C07D471/10 ,  A61K31/451 ,  C07D295/155 ,  A61K31/4035 ,  C07D209/44 ,  A61K31/277 ,  A61K31/438 ,  A61K31/185 ,  C07D495/10 ,  C07D221/20 ,  C07D307/68 ,  C07D213/65 ,  C07D295/192 ,  C07D211/58 ,  C07D211/16 ,  C07D513/10 ,  C07D209/46 ,  C07D209/42 ,  C07D277/56 ,  C07D209/08 ,  C07D498/04 ,  C07D207/267 ,  C07D493/08 ,  C07D207/10 ,  C07D491/10 ,  C07D487/08 ,  C07D487/04 ,  C07D261/18 ,  C07D257/04 ,  C07D249/18 ,  C07D417/12 ,  C07D241/12 ,  C07D409/12 ,  C07D409/04 ,  C07D405/12 ,  C07D239/22 ,  C07D239/20 ,  C07D235/30 ,  C07D401/12 ,  C07D401/04 ,  C07D333/70 ,  C07D233/38 ,  C07D233/36 ,  C07D231/18 ,  C07D231/14 ,  C07D317/68 ,  C07D215/12 ,  C07D213/81 ,  C07D213/75 ,  C07D401/14

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US10472337B2

公开(公告)日：2019-11-12

申请号：US16220046

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/5513 ,  C07D243/14 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D413/06 ,  C07D417/06 ,  C07D267/14 ,  C07D413/12 ,  C07D413/04 ,  C07D291/08 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10464909B2

公开(公告)日：2019-11-05

申请号：US16219381

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Heather Davis ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  Kenneth W. Bair ,  David S. Millan ,  Matthew W. Martin

IPC: A61K31/553 ,  C07D498/04 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10457655B2

公开(公告)日：2019-10-29

申请号：US15786539

申请日：2017-10-17

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  David R. Lancia, Jr. ,  Hongbin Li ,  James Loch ,  Wei Lu ,  Matthew W. Martin ,  David S. Millan ,  Shawn E.R. Schiller ,  Mark J. Tebbe

IPC: C07D295/192 ,  A61K31/4965 ,  A61P35/00 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D213/65 ,  C07D213/69 ,  C07D213/56 ,  C07D231/12 ,  C07D235/08 ,  C07D209/08 ,  C07D209/18 ,  C07D263/57 ,  C07D271/12 ,  C07D277/66 ,  C07D277/62 ,  C07D513/04 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  A61K45/06 ,  C07D215/14 ,  C07D231/56 ,  C07D257/04 ,  C07D305/08 ,  A61K31/497 ,  C07D217/16

Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US10450286B2

公开(公告)日：2019-10-22

申请号：US16389286

申请日：2019-04-19

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  David R. Lancia, Jr. ,  Hongbin Li ,  James Loch ,  Wei Lu ,  Matthew W. Martin ,  David S. Millan ,  Shawn E. R. Schiller ,  Mark J. Tebbe

IPC: C07D295/192 ,  A61K31/4965 ,  A61P35/00 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D213/65 ,  C07D213/69 ,  C07D213/56 ,  C07D231/12 ,  C07D235/08 ,  C07D209/08 ,  C07D209/18 ,  C07D263/57 ,  C07D271/12 ,  C07D277/66 ,  C07D277/62 ,  C07D513/04 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K45/06 ,  C07D217/16 ,  A61K31/5025 ,  A61K31/506 ,  C07D305/08 ,  C07D257/04 ,  C07D231/56 ,  C07D215/14

Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US10450283B2

公开(公告)日：2019-10-22

申请号：US16218132

申请日：2018-12-12

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin ,  Kenneth W. Bair

IPC: A61K31/553 ,  C07D267/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/04 ,  C07D243/14 ,  C07D291/08 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D498/08 ,  C07D493/08 ,  C07D413/08 ,  C07D491/107 ,  C07D495/10 ,  C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10414752B2

公开(公告)日：2019-09-17

申请号：US15964844

申请日：2018-04-27

Applicant: FORMA Therapeutics, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, Jr. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  A61P35/00 ,  A61K31/47

Abstract: The application relates to an inhibitor of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I-13):

公开(公告)号：US10414738B2

公开(公告)日：2019-09-17

申请号：US16218108

申请日：2018-12-12

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng ,  Pui Yee Ng ,  Bingsong Han ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Cuixian Liu ,  Aleksandra Rudnitskaya ,  David R. Lancia, Jr. ,  David S. Millan ,  Matthew W. Martin ,  Kenneth W. Bair

IPC: A61K31/553 ,  C07D498/04 ,  C07D267/14 ,  C07D413/12 ,  C07D267/12 ,  C07D413/06 ,  C07D401/06 ,  C07D417/04 ,  C07D471/04 ,  C07D243/14 ,  C07D291/08 ,  C07D498/08 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D405/06 ,  C07D413/14 ,  C07D495/10 ,  C07D491/107 ,  C07D413/08 ,  C07D493/08 ,  C07D413/04

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

公开(公告)号：US10377769B2

公开(公告)日：2019-08-13

申请号：US16029166

申请日：2018-07-06

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Torsten Herbertz ,  Goss S. Kauffman ,  Katherine J. Kayser-Bricker ,  George P. Luke ,  Matthew W. Martin ,  David S. Millan ,  Shawn E. R. Schiller ,  Adam C. Talbot ,  Mark J. Tebbe

IPC: C07D498/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4985 ,  A61K31/53 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D241/42 ,  C07D417/10 ,  C07D241/50 ,  C07D417/14 ,  C07D451/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  A61K45/06 ,  A61K31/498 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/506 ,  A61K31/517 ,  A61K31/55 ,  A61K31/553

Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.

公开(公告)号：US10377767B2

公开(公告)日：2019-08-13

申请号：US15909200

申请日：2018-03-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, Jr.

IPC: A61K31/519 ,  C07D495/04

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.