公开(公告)号：US20160251639A1

公开(公告)日：2016-09-01

申请号：US15156829

申请日：2016-05-17

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N9/22

CPC classification number: C12N15/907 ,  A61K31/7115 ,  A61K35/14 ,  A61K38/465 ,  A61K48/005 ,  A61K2035/124 ,  C07K14/195 ,  C07K2319/80 ,  C12N9/22 ,  C12N15/1024 ,  C12N15/86 ,  C12N2800/80 ,  C12Y301/00 ,  C12Y301/21004 ,  G01N33/5014

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20160010060A1

公开(公告)日：2016-01-14

申请号：US14810123

申请日：2015-07-27

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/077

CPC classification number: C12N5/0696 ,  C12N5/0018 ,  C12N5/0625 ,  C12N5/0647 ,  C12N5/0656 ,  C12N5/0657 ,  C12N5/0676 ,  C12N5/0695 ,  C12N2500/25 ,  C12N2500/33 ,  C12N2500/36 ,  C12N2500/84 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2506/45

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20150275193A1

公开(公告)日：2015-10-01

申请号：US14735603

申请日：2015-06-10

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N9/22 ,  C07K14/195

CPC classification number: C12N15/907 ,  A61K31/7115 ,  A61K35/14 ,  A61K38/465 ,  A61K48/005 ,  A61K2035/124 ,  C07K14/195 ,  C07K2319/80 ,  C12N9/22 ,  C12N15/1024 ,  C12N15/86 ,  C12N2800/80 ,  C12Y301/00 ,  C12Y301/21004 ,  G01N33/5014

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

Abstract translation: 本发明部分涉及编码蛋白质的核酸，包含编码蛋白质的核酸的治疗剂，使用核酸诱导细胞表达蛋白质的方法，用于转染，基因编辑和重编程细胞，细胞，生物体的方法，试剂盒和装置， 以及使用这些方法，试剂盒和装置制备的治疗剂。 描述了用于改变细胞DNA序列的方法和产物，以及用合成RNA分子诱导细胞表达蛋白质的方法和产物。 还描述了包含编码基因编辑蛋白的核酸的治疗剂。

公开(公告)号：US20150267189A1

公开(公告)日：2015-09-24

申请号：US14701199

申请日：2015-04-30

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N15/10 ,  C12N9/22 ,  C07K14/195

CPC classification number: C12N15/907 ,  A61K31/7115 ,  A61K35/14 ,  A61K38/465 ,  A61K48/005 ,  A61K2035/124 ,  C07K14/195 ,  C07K2319/80 ,  C12N9/22 ,  C12N15/1024 ,  C12N15/86 ,  C12N2800/80 ,  C12Y301/00 ,  C12Y301/21004 ,  G01N33/5014

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US09127248B2

公开(公告)日：2015-09-08

申请号：US13931251

申请日：2013-06-28

Applicant: Factor Bioscience, Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/00 ,  C12N5/074

CPC classification number: C12N5/0696 ,  C12N5/0018 ,  C12N5/0625 ,  C12N5/0647 ,  C12N5/0656 ,  C12N5/0657 ,  C12N5/0676 ,  C12N5/0695 ,  C12N2500/25 ,  C12N2500/33 ,  C12N2500/36 ,  C12N2500/84 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2506/45

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

Abstract translation: 本发明部分地涉及从患者样品中产生组织特异性细胞的方法以及使用这些方法产生的组织特异性细胞。 公开了使用RNA重编程细胞的方法。 还公开了包含使用这些方法生产的细胞的治疗剂。

公开(公告)号：US20150167019A1

公开(公告)日：2015-06-18

申请号：US14627666

申请日：2015-02-20

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N15/87 ,  C12N9/16

CPC classification number: C12N5/0647 ,  A61K35/28 ,  A61K2035/124 ,  C08G77/08 ,  C08K5/5399 ,  C12N5/0657 ,  C12N9/16 ,  C12N9/22 ,  C12N15/87 ,  C12N15/907 ,  C12N2500/25 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/2303 ,  C12N2501/26 ,  C12N2501/91 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2800/80 ,  C12P21/00 ,  C12Y301/21 ,  H01L31/048 ,  Y02E10/50 ,  C08L83/04

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

Abstract translation: 本发明部分涉及编码蛋白质的核酸，含有非标准核苷酸的核酸，包含核酸的治疗剂，用于诱导细胞表达蛋白质的方法，试剂盒和装置，用于转染，基因编辑的方法，试剂盒和装置， 并使用这些方法，试剂盒和装置重新编程细胞，细胞，生物体和治疗剂。 公开了诱导细胞表达蛋白质和使用RNA重编程和基因编辑细胞的方法。 还公开了从患者样品中产生细胞的方法，使用这些方法产生的细胞，以及包含使用这些方法产生的细胞的治疗剂。