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公开(公告)号:US20070116772A1
公开(公告)日:2007-05-24
申请号:US11398440
申请日:2006-04-05
申请人: Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人: Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
CPC分类号: A61K9/5146 , A61K9/5161 , A61K47/36 , A61K47/6931 , A61K47/6939 , B82Y5/00
摘要: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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公开(公告)号:US20070116678A1
公开(公告)日:2007-05-24
申请号:US11412610
申请日:2006-04-27
申请人: Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
发明人: Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
IPC分类号: A61K35/12
CPC分类号: A61K35/28 , A61K35/32 , A61L27/3817 , A61L27/3834 , A61L27/3843 , A61L27/52
摘要: A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The obtained living cell sheet is administered to a joint adapted for implantation and for cartilage regeneration.
摘要翻译: 一种新颖的方法,使用涂覆在TCPS皿上的热可逆MC / PBS /胶原水凝胶,用ECM收集活细胞片。 将获得的活细胞片施用于适于植入和软骨再生的关节。
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公开(公告)号:US20060177480A1
公开(公告)日:2006-08-10
申请号:US11130787
申请日:2005-05-17
申请人: Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
发明人: Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
IPC分类号: A61F2/00
CPC分类号: A61F2/82 , A61F2250/0098
摘要: The present invention relates to a biodegradable stent comprising a luminal surface portion with a second degree of crosslink, an outer surface portion with a first degree of crosslink, and a wall between the luminal and outer surface portions, wherein the wall comprises a crosslinked material characterized by the first degree of crosslink not less than the second degree of crosslink.
摘要翻译: 本发明涉及一种可生物降解的支架,其包括具有第二交联度的腔表面部分,具有第一度交联度的外表面部分以及腔和外表面部分之间的壁,其中所述壁包括交联材料, 通过第一交联度不低于第二交联度。
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公开(公告)号:US06998418B1
公开(公告)日:2006-02-14
申请号:US10408176
申请日:2003-04-07
申请人: Hsing-Wen Sung , Huang-Chien Liang , Hosheng Tu
发明人: Hsing-Wen Sung , Huang-Chien Liang , Hosheng Tu
CPC分类号: A61K38/1825 , A61K31/704 , A61K35/12 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61L27/3604 , A61L27/3687 , A61L27/38 , A61L27/56 , A61L2430/40 , A61K2300/00
摘要: A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
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公开(公告)号:US20050019404A1
公开(公告)日:2005-01-27
申请号:US10916170
申请日:2004-08-11
申请人: Hsing-Wen Sung , Mei-Chin Chen , Peter Tu , Hosheng Tu
发明人: Hsing-Wen Sung , Mei-Chin Chen , Peter Tu , Hosheng Tu
CPC分类号: A61L31/10 , A61F2/92 , A61F2210/0004 , A61F2230/0054 , A61F2230/0091 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要: The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured and arranged, in combination, radially, circumferentially and longitudinally.
摘要翻译: 本发明涉及装载药物的可生物降解支架以及用于治疗包括多层或多个区域的患者脆弱斑块的方法,每个层或区域包含其自身特定的生物降解速率及其特定的药物负载特性。 在一个实施例中,层和区域被组合和组合地径向地,周向地和纵向地布置。
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公开(公告)号:US06545042B2
公开(公告)日:2003-04-08
申请号:US10067130
申请日:2002-02-04
申请人: Hsing-Wen Sung , Huang-Chien Liang
发明人: Hsing-Wen Sung , Huang-Chien Liang
IPC分类号: A61K3135
CPC分类号: A61L27/3687 , A61F2310/00365 , A61F2310/00383 , A61L15/28 , A61L15/32 , A61L15/325 , A61L24/10 , A61L24/102 , A61L24/104 , A61L26/0023 , A61L26/0033 , A61L26/0038 , A61L27/20 , A61L27/22 , A61L27/222 , A61L27/24 , A61L27/3616 , A61L27/3645 , A61L27/3662 , A61L27/507 , A61L2430/40 , C08L5/08
摘要: A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
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