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129 条记录 (耗时 0.025 秒)

    Glycerol ether phosphatides
    121.
    发明授权
    Glycerol ether phosphatides 失效
    甘油醚磷脂

    公开(公告)号：US4694084A

    公开(公告)日：1987-09-15

    申请号：US709871

    申请日：1985-03-08

    申请人： Manfred Breuninger ,  Dieter Schmidt

    发明人： Manfred Breuninger ,  Dieter Schmidt

    IPC分类号： A61K9/107 ,  A61K9/127 ,  C07C43/13 ,  C07C43/164 ,  C07D317/12 ,  C07F9/10 ,  C07F9/59 ,  C07F9/58 ,  C07F9/65

    CPC分类号： C07F9/591 ,  A61K9/1075 ,  A61K9/1272 ,  C07C309/00 ,  C07C43/13 ,  C07C43/135 ,  C07C43/164 ,  C07D317/12 ,  C07F9/10

    摘要： Compounds of the general formula ##STR1## wherein two of the residues R.sup.1, R.sup.2 and R.sup.3 represent C.sub.10-30 -alkyl residues with at least 8 C-atoms in a straight chain, at least one of these residues being substituted by at least 2 C.sub.1-3 -alkyl residues and the sum of the C-atoms in the two residues being greater than 20; and the third residue is a residue --P(O)(O.sup.-)OR.sup.4 in which R.sup.4 represents a lower-alkyl or C.sub.5-7 -cycloalkyl residue which is substituted by a quaternary ammonium group or a C.sub.5-7 -cycloalkyl residue which contains a di-(lower-alkyl)-substituted nitrogen atom,are useful for the manufacture of colloidal solution systems. The compounds of formula I can be prepared starting from glycerol derivatives as described in more detail in the specification.

    摘要翻译： 通式为其中两个残基R 1，R 2和R 3表示在直链中具有至少8个C原子的C 10-30 - 烷基残基的化合物，这些残基中的至少一个被至少2个 C 3-烷基残基和两个残基中的C原子之和大于20; 并且第三个残基是残基-P（O）（-O-）OR 4，其中R 4表示被季铵基取代的低级烷基或C 5-7 - 环烷基残基或含有 二（低级 - 烷基）取代的氮原子可用于制造胶体溶液体系。 式I化合物可以从说明书中更详细描述的甘油衍生物开始制备。

    Porphyrin derivatives as fluorescent markers for immunoassays
    123.
    发明授权
    Porphyrin derivatives as fluorescent markers for immunoassays 失效
    卟啉衍生物作为免疫测定的荧光标记物

    公开(公告)号：US4614723A

    公开(公告)日：1986-09-30

    申请号：US613127

    申请日：1984-05-23

    申请人： Dieter Schmidt ,  Hans Steffen

    发明人： Dieter Schmidt ,  Hans Steffen

    IPC分类号： C07D487/22 ,  G01N33/533

    CPC分类号： C07D487/22 ,  G01N33/533 ,  Y10S436/80

    摘要： There are described novel porphyrin derivatives of the general formula ##STR1## wherein either R.sup.1 signifies the group ##STR2## and R.sup.2 signifies the group ##STR3## or R.sup.1 signifies the group ##STR4## and R.sup.2 signifies the group ##STR5## whereby X.sup.- signifies a halogen ion, an arylsulphonate ion, an alkylsulphonate ion or an alkyl sulphate ion, A signifies (C.sub.1-8)-alkylene and R.sup.3 signifies (C.sub.1-4)-alkyl,and sulphonic acid salts of compounds of formula I in which R.sup.1 signifies the group ##STR6## as well as a process for their manufacture and intermediates used in this process.Because of their water-solubility the novel porphyrin derivatives are suitable as label molecules for highly sensitive fluorescence immuno-assays, especially for time-resolving fluorescence immuno-assays. The coupling of the novel porphyrin derivatives to immunologically-active materials is carried out in the customary manner, for example with a water-soluble carbodiimide derivative.

    摘要翻译： 描述了通式为“IMAGE”I的新型卟啉衍生物，其中R1表示基团“IMAGE”，R2表示组 + TR ，或R1表示组，R2表示组< 其中X表示卤素离子，芳基磺酸根离子，烷基磺酸根离子或烷基硫酸根离子，A表示（C 1-8） - 亚烷基，R 3表示（C 1-4） - 烷基， 其中R1表示组的式I，以及其制造方法和在该方法中使用的中间体。 由于它们的水溶性，新的卟啉衍生物适用于高灵敏度荧光免疫分析的标签分子，特别是用于时间分辨荧光免疫测定。 新型卟啉衍生物与免疫活性物质的偶合以常规方式进行，例如用水溶性碳二亚胺衍生物进行。

    X-ray diagnostic system having an image intensifier television chain
    125.
    发明授权
    X-ray diagnostic system having an image intensifier television chain 失效
    具有图像增强器电视链的X射线诊断系统

    公开(公告)号：US4530007A

    公开(公告)日：1985-07-16

    申请号：US475747

    申请日：1983-03-16

    申请人： Dieter Schmidt

    发明人： Dieter Schmidt

    IPC分类号： H04N7/18 ,  A61B6/00 ,  H05G1/54 ,  H05G1/64 ,  H04N5/32

    CPC分类号： H05G1/64 ,  H05G1/54

    摘要： An x-ray diagnostic system having an image intensifier television chain includes sensors for respectively monitoring the presence of x-radiation from an x-ray tube, the presence of light at the output of an x-ray image intensifier, and the presence of a video signal corresponding to the x-ray image. Each sensor supplies an electronic signal to a safety circuit which is connected to the high voltage generator for the x-ray tube. If, after the presence of x-radiation is detected, no light and/or no video signal is detected, the safety circuit automatically disconnects the x-ray tube from the high voltage generator.

    摘要翻译： 具有图像增强电视链的x射线诊断系统包括用于分别监测来自X射线管的X射线的存在的传感器，x射线图像增强器的输出处的光的存在以及 视频信号对应于X射线图像。 每个传感器向连接到用于X射线管的高电压发生器的安全电路提供电子信号。 如果在检测到x辐射的存在之后，没有检测到光和/或没有视频信号，则安全电路自动将X射线管与高压发生器断开。

    Pharmaceutical compositions for parenteral or local administration
    126.
    发明授权
    Pharmaceutical compositions for parenteral or local administration 失效
    用于胃肠外或局部给药的药物组合物

    公开(公告)号：US4328222A

    公开(公告)日：1982-05-04

    申请号：US225880

    申请日：1981-01-19

    申请人： Dieter Schmidt

    发明人： Dieter Schmidt

    IPC分类号： A61K47/24

    CPC分类号： B82Y5/00 ,  A61K47/24 ,  A61K9/0019

    摘要： Colloidal aqueous vehicles, useful for the solubilization of insoluble or slightly soluble medicaments and suitable for parenteral or local administration, are disclosed. The vehicles contain, in addition to the medicaments, pharmaceutical adjuvants and a micelle-forming agent comprising short-chain lecithin and a non-hemolytic lipid.

    摘要翻译： 公开了用于溶解不溶性或微溶性药物并适用于胃肠外或局部给药的胶体水性载体。 除了药物之外，车辆还含有药物佐剂和包含短链卵磷脂和非溶血性脂质的胶束形成剂。

    Method of visualizing the flow pattern of a fluid using optically active, radioactive or chemically active particles of desired density
    127.
    发明授权
    Method of visualizing the flow pattern of a fluid using optically active, radioactive or chemically active particles of desired density 失效
    使用具有所需密度的光学活性的，放射性的或化学活性的颗粒使流体的流动图案可视化的方法

    公开(公告)号：US4264330A

    公开(公告)日：1981-04-28

    申请号：US98038

    申请日：1979-11-28

    申请人： Dieter Schmidt ,  Volkmar Delitzsch

    发明人： Dieter Schmidt ,  Volkmar Delitzsch

    IPC分类号： G01F1/704 ,  G01M10/00 ,  G01P13/00 ,  G01N21/17 ,  G01F1/70 ,  G09B23/12

    CPC分类号： G01F1/704 ,  G01M10/00 ,  G01P13/0013 ,  Y10T436/13

    摘要： The invention is concerned with particles consisting of a compound of an active material and foamed plastic, the mean density of the particles being adjustable to the special value of a foregiven fluid such that they can float in the fluid. Particles of this kind can be used (as "tracer" particles) for disturbance-free visualization of fluid flows and for suspending active materials of higher density than that of the fluid homogeneously in the fluid volume.Concerning the first usage, the flow pattern of a flowing aqueous fluid is visualized by spacedly suspending in the fluid approximately spherical particles of a foamed plastic labeled with zinc sulfide phosphor and having a diameter smaller than 0.5 millimeters and by exciting the phosphor with pulses from a UV laser. Successive frames taken by an electronic camera from an electronically intensified image of the liquid permit the direction and velocity of particle movement to be monitored as a measure of the flow pattern of the fluid which is not affected by the presence of the particles.

    摘要翻译： 本发明涉及由活性材料和发泡塑料的化合物组成的颗粒，颗粒的平均密度可调节到预定流体的特定值，使得它们可以漂浮在流体中。 可以使用这种颗粒（作为“示踪剂”颗粒）用于流体流动的无扰动可视化和用于在流体体积中均匀地悬浮高于流体的密度的活性材料。 关于第一次使用，流动的含水流体的流动模式通过间隔地悬浮在标有硫化锌荧光粉并且具有小于0.5毫米的直径的泡沫塑料的大致球形颗粒中，并且通过用来自 UV激光。 由电子照相机从液体的电子增强图像拍摄的连续帧允许要监测的颗粒运动的方向和速度作为不受颗粒存在影响的流体的流动模式的量度。

    Parenteral preparations
    129.
    发明授权
    Parenteral preparations 失效
    肠胃外制剂

    公开(公告)号：US4158707A

    公开(公告)日：1979-06-19

    申请号：US813913

    申请日：1977-07-08

    申请人： Hans Steffen ,  Dieter Schmidt

    发明人： Hans Steffen ,  Dieter Schmidt

    IPC分类号： A61K9/08 ,  A61K9/107 ,  A61K45/08 ,  A61K31/33 ,  A61K47/00

    CPC分类号： A61K9/1075

    摘要： Aqueous vehicles for insoluble or sparingly soluble medicaments suitable for parenteral administration are disclosed. The subject vehicles contain, in addition to pharmaceutical adjunct materials to render them isotonic, preserve them and the like, a micelle forming agent comprising cholic acid or a derivative thereof in combination with a lipoid.

    摘要翻译： 公开了适用于肠胃外给药的不溶性或微溶药物的水性载体。 本发明的载体除了含有等渗剂的药用辅料外，还含有包含胆酸或其衍生物与脂质组合的胶束形成剂。