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    METHOD FOR PRODUCING PURINE NUCLEONSIDE BY FERMENTATION
    121.
    发明申请
    METHOD FOR PRODUCING PURINE NUCLEONSIDE BY FERMENTATION 失效
    通过发酵生产磷酸核苷的方法

    公开(公告)号：US20070166799A1

    公开(公告)日：2007-07-19

    申请号：US11682114

    申请日：2007-03-05

    申请人： Hiroshi Matsui ,  Hisashi Kawasaki ,  Megumi Shimaoka ,  Yasuhiro Takenaka ,  Osamu Kurahashi

    发明人： Hiroshi Matsui ,  Hisashi Kawasaki ,  Megumi Shimaoka ,  Yasuhiro Takenaka ,  Osamu Kurahashi

    IPC分类号： C12P19/28 ,  C12N1/21

    CPC分类号： C12N9/1077 ,  C12P19/38 ,  C12P19/40 ,  C12R1/19

    摘要： A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a gene encoding an enzyme which is inactivated purine nucleoside phosphorylase encoded by deoD, a gene encoding an enzyme which is inactivated succinyl-AMP synthase encoded by purA, a gene encoding an enzyme which is inactivated 6-phosphogluconate dehydrase encoded by edd, a gene encoding an enzyme which is inactivated phosphoglucose isomerase encoded by pgi and like is bred and a purine nucleoside is produced by culturing the microorganism.

    摘要翻译： 具有编码酶的基因的微生物，其中通过用大肠杆菌的purF编码的PRPP酰胺转移酶中的一个或两个氨基酸取代反馈抑制而脱敏，该基因是编码由purR编码的嘌呤核苷酸生物合成的灭活性阻遏物的蛋白质 编码由deoD编码的失活的嘌呤核苷磷酸化酶的酶的基因，编码由purA编码的失活的琥珀酰-PAMP合酶的酶的基因，编码由edd编码的6-磷酸葡萄糖酸脱水酶的酶的基因， 编码由pgi等编码的失活的磷酸葡萄糖异构酶的酶，并通过培养微生物产生嘌呤核苷。

    Video signal processing apparatus
    123.
    发明申请
    Video signal processing apparatus 审中-公开
    视频信号处理装置

    公开(公告)号：US20060139496A1

    公开(公告)日：2006-06-29

    申请号：US11315982

    申请日：2005-12-22

    申请人： Hiroshi Matsui ,  Masato Onaya

    发明人： Hiroshi Matsui ,  Masato Onaya

    IPC分类号： H04N9/77 ,  H04N9/70 ,  H04N5/21

    CPC分类号： H04N9/78

    摘要： A video signal processing apparatus receives a video signal containing at least a luminance signal and a color difference signal. A trap filter attenuates a frequency band of the color difference signal to separate the luminance signal from the video signal. A bandpass filter attenuates a frequency band of the luminance signal to separate the color difference signal from the video signal. The trap filter is constituted by a switched capacitor filter that outputs the luminance signal with a delay time equivalent to a time difference between a delay time of the processing performed in a succeeding luminance signal processing circuit and a delay time of the processing performed in a color difference signal processing circuit. With this arrangement, the circuit scale of a filter circuit can be reduced and frequency characteristics of the filter can be stabilized.

    摘要翻译： 视频信号处理装置接收至少包含亮度信号和色差信号的视频信号。 陷波滤波器衰减色差信号的频带，以将亮度信号与视频信号分离。 带通滤波器衰减亮度信号的频带以将色差信号与视频信号分离。 陷波滤波器由开关电容滤波器构成，该开关电容滤波器输出亮度信号，其延迟时间等于在后续亮度信号处理电路中执行的处理的延迟时间与以颜色执行的处理的延迟时间之间的时间差 差分信号处理电路。 利用这种布置，可以降低滤波电路的电路规模，并且可以使滤波器的频率特性稳定。

    Solar cell
    124.
    发明申请
    Solar cell 有权
    太阳能电池

    公开(公告)号：US20050126629A1

    公开(公告)日：2005-06-16

    申请号：US11022672

    申请日：2004-12-28

    申请人： Kenichi Okada ,  Hiroshi Matsui ,  Nobuo Tanabe

    发明人： Kenichi Okada ,  Hiroshi Matsui ,  Nobuo Tanabe

    IPC分类号： H01L31/00

    CPC分类号： H01M14/005 ,  H01G9/2022 ,  H01G9/2031 ,  H01G9/2059

    摘要： A solar cell and photovoltaic power generation apparatus including a transparent electrically conductive film, a semiconductor provided on the transparent electrically conductive film, a conductive film opposing the semiconductor, and an electrolyte solution filled between the semiconductor and the conductive film. Metal ions, such as silver ions, may be dissolved in the electrolyte solution. When light is incident on the cell, the metal ions cause an oxidation-reduction reaction in the electrolyte solution and the cell is charged. When the open-circuit voltage decreases because the amount of incident light drops or light is blocked, the cell discharges to function as a secondary cell.

    摘要翻译： 一种太阳能电池和光伏发电装置，包括透明导电膜，设置在透明导电膜上的半导体，与半导体相对的导电膜，以及填充在半导体和导电膜之间的电解质溶液。 诸如银离子的金属离子可以溶解在电解质溶液中。 当光入射到电池上时，金属离子在电解质溶液中引起氧化还原反应，并且电池被充电。 当开路电压降低时，由于入射光的量下降或光线被阻挡，电池放电起二次电池的作用。

    Video signal processing circuit
    125.
    发明申请
    Video signal processing circuit 审中-公开
    视频信号处理电路

    公开(公告)号：US20050030430A1

    公开(公告)日：2005-02-10

    申请号：US10911892

    申请日：2004-08-05

    申请人： Hiroshi Matsui

    发明人： Hiroshi Matsui

    IPC分类号： G09G3/36 ,  G09G3/20 ,  G09G5/10 ,  H04N5/14 ,  H04N5/52 ,  H04N5/57 ,  H04N5/66 ,  H04N9/68 ,  H04N9/77

    CPC分类号： H04N9/68 ,  G09G3/3611 ,  G09G5/10 ,  G09G2320/066 ,  H04N9/77

    摘要： A video signal processing circuit comprises a luminance detector circuit for detecting the luminance of a video signal that is input and a contrast adjustment circuit for changing the contrast ratio of each chrominance signal in accordance with a detection result of the luminance detector circuit. As a result, when the luminance is low, for example, the contrast ratio can be increased in accordance with the luminance so that a clearer video image can be obtained.

    摘要翻译： 视频信号处理电路包括用于检测输入的视频信号的亮度的亮度检测器电路和用于根据亮度检测器电路的检测结果改变每个色度信号的对比度的对比度调整电路。 结果，当亮度低时，例如，可以根据亮度增加对比度，使得可以获得更清晰的视频图像。

    Method of producing heterocyclic derivatives
    126.
    发明授权
    Method of producing heterocyclic derivatives 失效
    制备杂环衍生物的方法

    公开(公告)号：US06489475B2

    公开(公告)日：2002-12-03

    申请号：US09784434

    申请日：2001-02-15

    申请人： Hiroshi Matsui ,  Shoji Kamiya

    发明人： Hiroshi Matsui ,  Shoji Kamiya

    IPC分类号： C07D20908

    CPC分类号： C07D231/12 ,  A61K31/404 ,  A61K31/47 ,  C07D209/08 ,  C07D215/06 ,  C07D215/26 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  Y10S514/824 ,  Y10S514/866

    摘要： Heterocyclic derivatives of the formula (I) wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and method of producing them. Pharmaceutical compositions containing the heterocyclic derivative or a pharmaceutically acceptable salt thereof, particularly, ACAT inhibitors and lipoperoxidation inhibitors. The heterocyclic derivatives and pharmaceutically acceptable salts thereof of the present invention show superior ACAT inhibitory activity and lipoperoxidation inhibitory activity, and are useful as ACAT inhibitors and hyperlipemia inhibitors. To be specific, they are useful for the prevention and treatment of arteriosclerotic lesions of arteriosclerosis, hyperlipemia and diabetes, as well as ischemic diseases of brain, heart and the like.

    摘要翻译： 式（I）的杂环衍生物，其中每个符号如说明书中所定义，其药学上可接受的盐及其制备方法。 含有杂环衍生物或其药学上可接受的盐，特别是ACAT抑制剂和脂质过氧化抑制剂的药物组合物。 本发明的杂环衍生物及其药学上可接受的盐显示出优异的ACAT抑制活性和脂质过氧化抑制活性，并且可用作ACAT抑制剂和高脂血症抑制剂。 具体而言，它们可用于预防和治疗动脉硬化，高脂血症和糖尿病的动脉硬化病变，以及脑，心脏等的缺血性疾病。

    Carbapenem compounds, use thereof, and intermediate compounds of the same
    127.
    发明授权
    Carbapenem compounds, use thereof, and intermediate compounds of the same 失效
    碳青霉烯化合物及其中间体化合物

    公开(公告)号：US06342494B1

    公开(公告)日：2002-01-29

    申请号：US09355757

    申请日：1999-08-04

    申请人： Hiroshi Matsui ,  Masayasu Kasai

    发明人： Hiroshi Matsui ,  Masayasu Kasai

    IPC分类号： C07D47720

    CPC分类号： C07D477/20 ,  A61K31/407 ,  Y02P20/55

    摘要： A carbapenem compound of the formula (I) wherein R1 is a group hydrolyzable in the body, R2 is selected from the group consisting of aryl groups optionally substituted by 1-3 alkyl groups having 1-4 carbon atoms, 1-alkanoyloxyalkyl, 1-alkoxycarbonyloxyalkyl, phthalidyl and 5-methyl-2-oxo-1,3-dioxolen-4-ylmethyl, R3 and R4 are lower alkyl groups which may be the same or different or instead form a 4- to 6-membered cyclic amino with the adjacent nitrogen selected from the group consisting of azetidinyl, pyrrolidinyl and piperidinyl or a pharmaceutically acceptable salt thereof The carbapenem compound (I) and a pharmaceutically acceptable salt thereof of the present invention show superior absorption from digestive tract by oral administration, and sufficient antibacterial activity against a wide variety of bacterial species. Thus, they are extremely useful as agents for the prophylaxis and treatment of infectious diseases, particularly bacterial infectious diseases. Said agents for the prophylaxis and treatment of infectious diseases can be used as agents for the prophylaxis and treatment of the diseases caused by bacteria (e.g., suppurative diseases, respiratory infectious diseases, inflammatory diseases of biliary tract, urinary tract infection and the like) in warm-blooded animals inclusive of human (e.g., dog, cat, cow, horse, rat, mouse and the like).

    摘要翻译： 式（I）的碳青霉烯化合物，其中R 1是在体内可水解的基团，R 2选自任选被1-3个具有1-4个碳原子的烷基取代的芳基，1-烷酰氧基烷基， 烷氧基羰基氧基烷基，邻苯二甲酰基和5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基甲基，R 3和R 4是可以相同或不同的低级烷基，或者形成4-至6-元环状氨基， 选自氮杂环丁烷基，吡咯烷基和哌啶基的相邻氮或其药学上可接受的盐本发明的碳青霉烯化合物（I）及其药学上可接受的盐通过口服给药对消化道具有优异的吸收性，并且具有足够的抗细菌活性 各种细菌种类。 因此，它们作为用于预防和治疗感染性疾病，特别是细菌感染性疾病的药剂是非常有用的。 所述用于预防和治疗感染性疾病的药剂可用作预防和治疗由细菌引起的疾病（例如，化脓性疾病，呼吸道感染性疾病，胆道炎性疾病，尿路感染等）的药物 包括人类（例如狗，猫，牛，马，老鼠，老鼠等）的温血动物。

    Multidirectional controller and multidirectional controlling device using the same
    128.
    发明授权
    Multidirectional controller and multidirectional controlling device using the same 失效
    多向控制器和使用其的多向控制装置

    公开(公告)号：US06181323B2

    公开(公告)日：2001-01-30

    申请号：US09010937

    申请日：1998-01-22

    申请人： Hideki Shigemoto ,  Hiroshi Matsui ,  Yukihiro Ishihara

    发明人： Hideki Shigemoto ,  Hiroshi Matsui ,  Yukihiro Ishihara

    IPC分类号： G09G500

    CPC分类号： G06F3/0362 ,  H01H25/00 ,  H01H2019/146

    摘要： A multidirectional controller includes: a substrate having a first end portion and a second end portion, which sways via a supporting point provided at the first end portion; an electronic part provided at the second end portion, which includes a control portion which is manipulated in a predetermined direction in which the electronic part causes the substrate to sway when the electronic part is manipulated; a supporting member for supporting the substrate; and a switch provided so as to be switched in response to the sway of the substrate, when the electronic part is manipulated in the predetermined direction.

    摘要翻译： 多向控制器包括：具有第一端部和第二端部的基板，经由设置在第一端部处的支撑点摇动; 设置在所述第二端部处的电子部件，所述电子部件包括控制部，所述控制部在所述电子部件被操纵时沿所述电子部件使所述基板摆动的规定方向被操作; 用于支撑衬底的支撑构件; 以及当沿预定方向操纵电子部件时，响应于基板的摆动而设置的开关被设置为被切换。