公开(公告)号：US6077688A

公开(公告)日：2000-06-20

申请号：US965600

申请日：1997-11-06

申请人： Olga Bandman ,  Preeti Lal ,  Neil C. Corley ,  Purvi Shah

发明人： Olga Bandman ,  Preeti Lal ,  Neil C. Corley ,  Purvi Shah

IPC分类号： C07K14/47 ,  C12N1/21 ,  C12P21/06 ,  C07H21/02 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K14/4722

摘要： The invention provides a human transducin beta-1 subunit (TBS) and polynucleotides which identify and encode TBS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating or preventing diseases associated with expression of TBS.

公开(公告)号：US5989859A

公开(公告)日：1999-11-23

申请号：US967364

申请日：1997-11-07

申请人： Olga Bandman ,  Preeti Lal ,  Karl J. Guegler ,  Purvi Shah ,  Neil C. Corley

发明人： Olga Bandman ,  Preeti Lal ,  Karl J. Guegler ,  Purvi Shah ,  Neil C. Corley

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07H21/04 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/4701 ,  A61K38/00

摘要： The invention provides three human vesicle trafficking proteins (VTP) and polynucleotides which identify and encode VTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of VTP.

公开(公告)号：US5976801A

公开(公告)日：1999-11-02

申请号：US910927

申请日：1997-08-08

申请人： Olga Bandman ,  Jennifer L. Hillman ,  Preeti Lal ,  Neil C. Corley ,  Purvi Shah

发明人： Olga Bandman ,  Jennifer L. Hillman ,  Preeti Lal ,  Neil C. Corley ,  Purvi Shah

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/4728 ,  A61K38/00

摘要： The invention provides two human reticulocalbin isoforms designated individually as RCN .gamma. and RCN .delta. and collectively as RCN, and polynucleotides which identify and encode RCN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of RCN.

公开(公告)号：US5922318A

公开(公告)日：1999-07-13

申请号：US134596

申请日：1998-08-13

申请人： Olga Bandman ,  Neil C. Corley ,  Preeti Lal ,  Purvi Shah

发明人： Olga Bandman ,  Neil C. Corley ,  Preeti Lal ,  Purvi Shah

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/53 ,  A61K45/00 ,  A61P21/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12Q1/68 ,  A61K38/43

CPC分类号： C12N9/93 ,  A61K38/00 ,  Y10S530/827

摘要： The present invention provides a human ubiquitin conjugation system protein (UCSP) and polynucleotides which encode UCSP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of UCSP.

公开(公告)号：US5871973A

公开(公告)日：1999-02-16

申请号：US951148

申请日：1997-10-15

申请人： Jennifer L. Hillman ,  Olga Bandman ,  Preeti Lal ,  Purvi Shah ,  Neil C. Corley

发明人： Jennifer L. Hillman ,  Olga Bandman ,  Preeti Lal ,  Purvi Shah ,  Neil C. Corley

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  C07K14/435

CPC分类号： C07K14/4738 ,  A61K38/00

摘要： The invention provides three human cell division regulators (HCDR) and polynucleotides which identify and encode HCDR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of HCDR.

公开(公告)号：US5866119A

公开(公告)日：1999-02-02

申请号：US867676

申请日：1997-06-02

申请人： Olga Bandman ,  Preeti Lal ,  Neil C. Corley

发明人： Olga Bandman ,  Preeti Lal ,  Neil C. Corley

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/46 ,  A61P29/00 ,  A61P43/00 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/22 ,  C12N15/55 ,  C12Q1/02 ,  C12Q1/68 ,  A61K38/47

CPC分类号： C12N9/22 ,  A61K38/00

摘要： This invention relates to nucleic acid and amino acid sequences of a new human ribonuclease and to the use of these sequences in the diagnosis, prevention and treatment of inflammation and disorders associated with cell proliferation and apoptosis.

摘要翻译： 本发明涉及新的人核糖核酸酶的核酸和氨基酸序列，以及这些序列用于诊断，预防和治疗与细胞增殖和凋亡有关的炎症和病症的用途。

公开(公告)号：US5849528A

公开(公告)日：1998-12-15

申请号：US918727

申请日：1997-08-21

申请人： Jennifer L. Hillman ,  Olga Bandman ,  Neil C. Corley ,  Preeti Lal ,  Purvi Shah

发明人： Jennifer L. Hillman ,  Olga Bandman ,  Neil C. Corley ,  Preeti Lal ,  Purvi Shah

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12P21/00 ,  C07H21/04 ,  C07K14/46 ,  C12N1/21

CPC分类号： C07K14/4728 ,  A61K38/00

摘要： The invention provides two human S100 proteins designated individually as S100P1 and S100P2 and collectively as S100P, and polynucleotides which identify and encode S100P. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of S100P.

公开(公告)号：US07947804B1

公开(公告)日：2011-05-24

申请号：US09556178

申请日：2000-04-20

申请人： Olga Bandman ,  Preeti Lal ,  Karl J. Guegler ,  Purvi Shah ,  Neil C. Corley

发明人： Olga Bandman ,  Preeti Lal ,  Karl J. Guegler ,  Purvi Shah ,  Neil C. Corley

IPC分类号： C07K14/00 ,  C07K17/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/4701 ,  A61K38/00

摘要： The invention provides three human vesicle trafficking proteins (VTP) and polynucleotides which identify and encode VTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of VTP.

摘要翻译： 本发明提供了三种人囊泡运输蛋白（VTP）和识别和编码VTP的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了预防和治疗与VTP表达相关的疾病的方法。

公开(公告)号：US07238506B1

公开(公告)日：2007-07-03

申请号：US09301872

申请日：1999-04-29

申请人： Jennifer L. Hillman ,  Olga Bandman ,  Preeti Lal ,  Neil C. Corley

发明人： Jennifer L. Hillman ,  Olga Bandman ,  Preeti Lal ,  Neil C. Corley

IPC分类号： C12N9/00 ,  C12N9/02 ,  C12N1/12 ,  C07H21/04

CPC分类号： C12N9/0038 ,  A61K38/00 ,  C12N9/0053

摘要： The invention provides human electron transport proteins (NHETP) and polynucleotides which identify and encode NHETP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of NHETP.

摘要翻译： 本发明提供了识别和编码NHETP的人电子转运蛋白（NHETP）和多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗或预防与NHETP表达相关的病症的方法。

公开(公告)号：US20070026449A1

公开(公告)日：2007-02-01

申请号：US11534950

申请日：2006-09-25

申请人： Preeti Lal ,  Olga Bandman

发明人： Preeti Lal ,  Olga Bandman

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6872

摘要： The present invention provides a human sodium-dependent phosphate cotransporter (NAPTR) and polynucleotides which identify and encode NAPTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NAPTR and a method for producing NAPTR. The invention also provides for agonists, antibodies, or antagonists specifically for NAPTR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NAPTR for the treatment of diseases associated with the expression of NAPTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NAPTR. The invention also provides a method for treating disorders associated with decreased phosphate levels by administering NAPTR and a method for treating disorders associated with increased phosphate levels by administering antagonists to NAPTR.

摘要翻译： 本发明提供了人类钠依赖性磷酸盐协同转运体（NAPTR）和识别和编码NAPTR的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NAPTR的核酸序列和产生NAPTR的方法。 本发明还提供了专门用于NAPTR的激动剂，抗体或拮抗剂。 另外，本发明提供了反义分子用于编码NAPTR的多核苷酸用于治疗与NAPTR表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NAPTR的抗体的诊断测定法。 本发明还提供了一种通过施用NAPTR来治疗与磷酸盐水平降低相关的疾病的方法，以及通过向NAPTR施用拮抗剂来治疗与磷酸盐水平升高相关的疾病的方法。