公开(公告)号：US09709649B2

公开(公告)日：2017-07-18

申请号：US14175518

申请日：2014-02-07

申请人： Qiang Xiong ,  Jianyi Zhang

发明人： Qiang Xiong ,  Jianyi Zhang

IPC分类号： G01R33/485

CPC分类号： G01R33/485

摘要： A system and method for acquiring and using inversion-recovery data and spectral data. In particular, the inversion-recovery data and spectral data can be used to determine adenosine triphosphate (ATP) hydrolysis rate of a subject without a quantification of inorganic phosphate.

公开(公告)号：US20170192070A1

公开(公告)日：2017-07-06

申请号：US15081009

申请日：2016-03-25

申请人： Toshiba Medical Systems Corporation

发明人： Mitsue MIYAZAKI ,  Xiangzhi Zhou

IPC分类号： G01R33/485 ,  G01R33/483

摘要： A magnetic resonance imaging apparatus according to an embodiment includes sequence control circuitry. The sequence control circuitry applies an MT (Magnetization Transfer) pulse over a plurality of slices under a gradient magnetic field and configured to apply, for each of the plurality of slices to which the MT pulse is applied, an RF pulse having a frequency corresponding to a resonance frequency of certain protons in each of the plurality of slices.

公开(公告)号：US09588204B2

公开(公告)日：2017-03-07

申请号：US14363510

申请日：2012-12-04

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Lyubomir Georgiev Zagorchev ,  Stewart Young

IPC分类号： G01V3/00 ,  G01R33/48 ,  A61B5/055 ,  G01R33/483 ,  G01R33/485 ,  G01R33/56 ,  A61B5/00 ,  G01R33/54

CPC分类号： G01R33/4828 ,  A61B5/055 ,  A61B5/7485 ,  G01R33/483 ,  G01R33/485 ,  G01R33/543 ,  G01R33/5608

摘要： A MRSI system (100) includes a structure of interest identifier (206) that identifies a predetermined segmented structure in segmented MRI image data, a positioning rules bank (210) which stores rules for positioning a volume of interest with respect to the identified predetermined segmented structure of the segmented MRI image data, and a volume of interest generator (208) that positions the volume of interest with respect to the identified predetermined segmented structure based on one or more of the rules for positioning the volume of interest with respect to the identified predetermined segmented structure and generates a signal indicative thereof, wherein the signal is analyzed to determine a biochemical composition of a predetermined region of the structure of interest.

摘要翻译： MRSI系统（100）包括识别分割的MRI图像数据中的预定分段结构的兴趣标识符结构（206），定位规则库（210），其存储用于相对于所识别的预定分段的定位感兴趣体积的规则 分割的MRI图像数据的结构，以及感兴趣生成器（208）的体积，其基于用于相对于所识别的用于定位的感兴趣体积的一个或多个规则来定位关于所识别的预定分段结构的感兴趣体积 预定的分段结构并产生指示其的信号，其中分析信号以确定感兴趣结构的预定区域的生化成分。

公开(公告)号：US20160349339A1

公开(公告)日：2016-12-01

申请号：US15169166

申请日：2016-05-31

申请人： Case Western Reserve University

发明人： Susann Brady-Kalnay ,  Vikas Gulani ,  Mark Griswold ,  Chris Flask

IPC分类号： G01R33/44 ,  G01R33/563 ,  G01R33/56 ,  G01R33/48 ,  G01R33/485

CPC分类号： G01R33/5614 ,  G01R33/50 ,  G01R33/56509 ,  G01R33/56563

摘要： A system and method is provided for operating a high-field magnetic resonance (MR) system includes performing a series of data acquisition modules without respiratory gating. Each data acquisition module is formed of a steady-state free precession pulse sequence. Performing the series of data acquisition modules includes varying at least one of an amplitude of an excitation pulse or a repetition time of the steady-state free precession pulse sequence between adjacent data acquisition modules in the series of data acquisition modules to acquire a series of MR data with random or pseudo-random imaging acquisition parameters. The series of MR data is compared to a dictionary of signal evolution profiles to determine a match between the series of MR data with at least one signal evolution profile in the dictionary indicating at least one quantitative parameter in the subject.

摘要翻译： 提供用于操作高场磁共振（MR）系统的系统和方法包括执行一系列无呼吸门控的数据采集模块。 每个数据采集模块由稳态自由进动脉冲序列组成。 执行一系列数据采集模块包括改变一系列数据采集模块中的相邻数据采集模块之间的稳态自由进动脉冲序列的激励脉冲的幅度或重复时间中的至少一个，以获得一系列MR 数据随机或伪随机成像采集参数。 将MR数据系列与信号进化曲线的字典进行比较，以确定该系列MR数据与字典中至少一个信号进化曲线之间的匹配，以指示对象中的至少一个定量参数。

公开(公告)号：US09280718B2

公开(公告)日：2016-03-08

申请号：US13830632

申请日：2013-03-14

申请人： NociMed, LLC

发明人： John P. Claude ,  James C. Peacock, III ,  Paul H. Kane

IPC分类号： G06K9/00 ,  G06K9/34 ,  A61B5/055 ,  G01R33/485 ,  G01R33/54 ,  G06T7/00

CPC分类号： A61B5/055 ,  A61B5/4566 ,  G01R33/4835 ,  G01R33/485 ,  G01R33/543 ,  G06K9/34 ,  G06T7/11 ,  G06T7/12 ,  G06T7/62 ,  G06T2207/10088 ,  G06T2207/30012

摘要： A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).

摘要翻译： 提供了一种用于在患者组织中的唯一可定义的感兴趣区域（ROI）中自动化适当体素处方的系统和方法，例如用于在ROI中进行磁共振波谱（MRS）的目的。 自动识别单个感兴趣区域（ROI）内单个三维直线体积（体素）的尺寸和坐标。 这在一些实施例中通过以下方式完成：（1）在视场（FOV）内应用统计识别的ROI搜索区域; （2）图像处理MRI图像以平滑背景并增强用于定义ROI的特定结构; （3）识别定义特定结构的像素群; （4）对像素群体进行统计分析，以将诸如椭圆体的2D模型拟合到群体中，并随后在模型内拟合直线形状; （5）使用包含3D ROI的多个图像重复元件（1）至（4）以产生3D直线形状; （6）用于具有公共FOV的多个ROI的元件（1）至（5）的重复。 也可以提供手动界面，允许通过手动处方来替代，以识别结构（例如，点击盘级别）或修改自动体素（例如，修改位置，形状或一个或多个维度）。

公开(公告)号：US09234953B2

公开(公告)日：2016-01-12

申请号：US13522696

申请日：2010-01-18

申请人： Christian Labadie ,  Stefan Hetzer ,  Toralf Mildner ,  Harald Moeller

发明人： Christian Labadie ,  Stefan Hetzer ,  Toralf Mildner ,  Harald Moeller

IPC分类号： G01R33/56 ,  G01R33/34 ,  G01R33/485 ,  G01R33/48 ,  G01R33/561

CPC分类号： G01R33/485 ,  G01R33/4818 ,  G01R33/482 ,  G01R33/5611 ,  G01R33/5616

摘要： A method of magnetic resonance spectroscopic imaging of an object (O) including at least one chemical species to be imaged, comprising sampling of the k-space such that a plurality of Nω first sampling trajectories through at least one k-space segment of the k-space is formed along a phase-encoding direction, each of said first sampling trajectories beginning in a central k-space region and continuing to a k-space border of the at least one k-space segment and having a duration equal to or below a spectral dwell time corresponding to the reciprocal spectral bandwidth, collecting at least one first set of gradient-echo signals obtained along the first sampling trajectories, collecting at least one second set of gradient-echo signals obtained along a plurality of Nω second sampling trajectories, the Nω second sampling trajectories and the Nω first sampling trajectories being mutually mirrored relative to a predetermined k-space line in the central k-space region.

摘要翻译： 包括至少一种待成像化学物质的物体（O）的磁共振光谱成像方法，包括k空间的采样，使得多个Nω第一采样轨迹通过k的至少一个k空间段 - 空间沿着相位编码方向形成，所述第一采样轨迹中的每一个从中心k空间区域开始并且连续至少一个k空间段的k空间边界并具有等于或低于 收集对应于所述倒数光谱带宽的光谱驻留时间，收集沿着所述第一采样轨迹获得的至少一个第一梯度回波信号集合，收集沿着多个Nω第二采样轨迹获得的至少一个第二组梯度回波信号， Nω第二采样轨迹和Nω第一采样轨迹相对于中心k空间区域中的预定k空间线相互镜像。

公开(公告)号：US09204817B2

公开(公告)日：2015-12-08

申请号：US13451250

申请日：2012-04-19

申请人： Sheshadri Thiruvenkadam ,  Dattesh Dayanand Shanbhag ,  Rakesh Mullick ,  Florian Wiesinger ,  Sandeep Suryanarayana Kaushik

发明人： Sheshadri Thiruvenkadam ,  Dattesh Dayanand Shanbhag ,  Rakesh Mullick ,  Florian Wiesinger ,  Sandeep Suryanarayana Kaushik

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/563 ,  A61B6/03 ,  G01R33/485 ,  G01R33/56 ,  A61B6/00

CPC分类号： A61B5/055 ,  A61B5/0035 ,  A61B6/037 ,  A61B6/463 ,  A61B6/5247 ,  A61B6/582 ,  G01R33/481 ,  G01R33/485 ,  G01R33/5602 ,  G01R33/56383

摘要： In one embodiment, a method includes performing a magnetic resonance (MR) imaging sequence to acquire MR image slices or volumes of a first station representative of a portion of a patient; applying a first phase field algorithm to the first station to determine a body contour of the patient in the first station; identifying a contour of a first anatomy of interest within the body contour of the first station using the first phase field algorithm or a second phase field algorithm; segmenting the first anatomy of interest based on the identified contour of the first anatomy of interest; correlating first attenuation information to the segmented first anatomy of interest; and modifying a positron emission tomography (PET) image based at least on the first correlated attenuation information.

摘要翻译： 在一个实施例中，一种方法包括执行磁共振（MR）成像序列以获取表示患者的一部分的第一站的MR图像切片或体积; 将第一相位场算法应用于所述第一站以确定所述第一站中的所述患者的身体轮廓; 使用第一相位场算法或第二相位算法，在第一站的身体轮廓内识别感兴趣的第一解剖结构的轮廓; 基于感兴趣的第一解剖结构的识别轮廓来分割感兴趣的第一解剖结构; 将第一衰减信息与感兴趣的分段的第一解剖结构相关联; 以及至少基于所述第一相关衰减信息修改正电子发射断层摄影（PET）图像。

公开(公告)号：US09157975B2

公开(公告)日：2015-10-13

申请号：US14061798

申请日：2013-10-24

申请人： Brian Dale

发明人： Brian Dale

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/56 ,  G01R33/50 ,  G01R33/485

CPC分类号： G01R33/4828 ,  A61B5/055 ,  G01R33/485 ,  G01R33/50 ,  G01R33/5608

摘要： A computer-implemented method for concurrently estimating the amount of fat and iron in anatomical tissue from magnetic resonance (MR) signal data includes receiving a test signal representative of the anatomical tissue acquired using a MR pulse sequence type. A repository of reference signal data is generated. The repository comprises a plurality of reference signals derived by an MR signal simulation for a plurality of different transverse relaxation rates, a plurality of different fat fractions, and the MR pulse sequence type. A first reference signal is identified in the plurality of reference signals. The first reference signal provides a best match to the test signal based on one or more matching criteria. The repository is searched to determine a first transverse relaxation rate and a first fat fraction associated with the first reference signal. Then, the amount of fat and iron in the anatomical tissue is estimated based on the first transverse relaxation rate and the first fat fraction.

摘要翻译： 用于从磁共振（MR）信号数据同时估计解剖组织中的脂肪和铁的量的计算机实现的方法包括接收代表使用MR脉冲序列类型获取的解剖组织的测试信号。 生成参考信号数据库。 存储库包括通过用于多个不同横向松弛率的MR信号模拟导出的多个参考信号，多个不同的脂肪分数和MR脉冲序列类型。 在多个参考信号中识别出第一参考信号。 第一参考信号基于一个或多个匹配标准提供对测试信号的最佳匹配。 搜索储存库以确定与第一参考信号相关联的第一横向松弛率和第一脂肪分数。 然后，基于第一横向松弛率和第一脂肪分数来估计解剖组织中的脂肪和铁的量。

公开(公告)号：US09134391B2

公开(公告)日：2015-09-15

申请号：US13422210

申请日：2012-03-16

申请人： Elisabeth Weiland

发明人： Elisabeth Weiland

IPC分类号： G01R33/44 ,  G01R33/46 ,  G01R33/485 ,  G01R33/565

CPC分类号： G01R33/4625 ,  G01R33/485 ,  G01R33/565

摘要： In a method and device to detect interference signals in magnetic resonance spectroscopy signals a comparison signal is computationally reconstructed that optimally approximates a measured, detected magnetic resonance spectroscopy signal. The comparison signal forms spectral components of resonance lines of the measured magnetic resonance spectroscopy signal. A residual is calculated from the difference of the two signals (comparison signal and magnetic resonance spectroscopy signal) in the frequency representation. The interference signals are determined from the residual.

摘要翻译： 在用于检测磁共振光谱信号中的干扰信号的方法和装置中，计算重建比较信号，其最佳地接近测量的检测到的磁共振光谱信号。 比较信号形成测量的磁共振波谱信号的谐振线的光谱分量。 根据频率表示中的两个信号（比较信号和磁共振波谱信号）的差计算残差。 干扰信号由残差确定。

公开(公告)号：US20150061667A1

公开(公告)日：2015-03-05

申请号：US14476917

申请日：2014-09-04

申请人： Siemens Aktiengesellschaft

发明人： Marcel Dominik Nickel

IPC分类号： G01R33/485 ,  G01R33/565 ,  A61B5/055 ,  G01R33/46

CPC分类号： G01R33/485 ,  A61B5/055 ,  G01R33/46 ,  G01R33/4828 ,  G01R33/56518 ,  G01R33/56563

摘要： Magnetic resonance (MR) data are acquired with a two-point Dixon technique in which a first spectral component and a second spectral component, for example, a water component and a fat component, are determined. A computation grid of lower resolution in comparison to the MR data is determined, wherein each grid point of the computation grid encompasses a predetermined number of adjacent image points of the MR data. A numerical optimization is implemented for each image point of the MR data, and the first spectral component and the second spectral component are calculated analytically based on the result of the numerical optimization.

摘要翻译： 磁共振（MR）数据采用两点Dixon技术获得，其中确定了第一光谱分量和第二光谱分量，例如水分量和脂肪分量。 确定与MR数据相比较低分辨率的计算网格，其中计算网格的每个网格点包含MR数据的预定数量的相邻图像点。 对MR数据的每个图像点进行数值优化，并根据数值优化的结果对第一个光谱分量和第二个光谱分量进行分析计算。