公开(公告)号：US08886271B2

公开(公告)日：2014-11-11

申请号：US13919692

申请日：2013-06-17

Applicant: Cercacor Laboratories, Inc.

Inventor： Abraham Mazda Kiani ,  Massi Joe E. Kiani

IPC: A61B5/02 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/02416 ,  A61B5/02427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6816 ,  A61B5/6819 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6832 ,  A61B5/6838

Abstract: A sensor cover according to embodiments of the disclosure is capable of being used with a non-invasive physiological sensor, such as a pulse oximetry sensor. Certain embodiments of the sensor cover reduce or eliminate false readings from the sensor when the sensor is not in use, for example, by blocking a light detecting component of a pulse oximeter sensor when the pulse oximeter sensor is active but not in use. Further, embodiments of the sensor cover can prevent damage to the sensor. Additionally, embodiments of the sensor cover prevent contamination of the sensor.

Abstract translation: 根据本公开的实施例的传感器盖能够与非侵入性生理传感器（例如脉搏血氧饱和度传感器）一起使用。 当传感器不使用时，传感器盖的某些实施例可减少或消除来自传感器的错误读数，例如当脉搏血氧计传感器处于活动但未使用时通过阻挡脉搏血氧计传感器的光检测部件。 此外，传感器盖的实施例可以防止对传感器的损坏。 此外，传感器盖的实施例防止了传感器的污染。

公开(公告)号：US20140330098A1

公开(公告)日：2014-11-06

申请号：US14330273

申请日：2014-07-14

Applicant: CERCACOR LABORATORIES, INC.

Inventor： SEAN MERRITT ,  MARCELO LAMEGO

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/1455

Abstract: A noninvasive or minimally invasive procedure and system for measuring blood glucose levels is disclosed. A set of photodiodes detects the fluorescence and reflectance of light energy emitted from one or more emitters, such as LEDs, into a patient's skin. In an embodiment, small molecule metabolite reporters (SMMRs) that bind to glucose are introduced to the measurement area to provide more easily detected fluorescence.

Abstract translation: 公开了一种用于测量血糖水平的无创或微创手术和系统。 一组光电二极管检测从一个或多个发射器（例如LED）发射到患者皮肤中的光能的荧光和反射率。 在一个实施方案中，将结合葡萄糖的小分子代谢报告物（SMMR）引入测量区域以提供更容易检测的荧光。

公开(公告)号：US20140276115A1

公开(公告)日：2014-09-18

申请号：US14203376

申请日：2014-03-10

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Cristiano Dalvi ,  Marcelo M. Lamego

IPC: A61B5/00 ,  A61B5/024

CPC classification number: A61B5/7415 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/04028 ,  A61B5/14551 ,  A61B5/7221 ,  A61B5/7278

Abstract: The disclosure includes systems and methods directed toward simulating heart sounds. The system can include an optical sensor configured to obtain data for generating a plurality of plethysmograph waveforms at a first frequency. The heart sound simulator can also include a processor in communication with the sensor. The processor can be configured to generate a heart sound signal based on at least one of the plurality of plethysmograph waveforms.

Abstract translation: 本公开包括用于模拟心脏声音的系统和方法。 该系统可以包括被配置为获得用于产生第一频率的多个体积描记器波形的数据的光学传感器。 心音模拟器还可以包括与传感器通信的处理器。 处理器可以被配置为基于多个体积描记器波形中的至少一个产生心音信号。

公开(公告)号：US20140275872A1

公开(公告)日：2014-09-18

申请号：US14204708

申请日：2014-03-11

Applicant: Cercacor Laboratories, Inc.

Inventor： Sean Merritt ,  Kevin Pauley ,  Jesse Chen ,  Justin Mathew Paul ,  Marcelo M. Lamego

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/6826 ,  A61B2560/0233 ,  G01N21/278

Abstract: A quality control system for patient monitors is disclosed. The quality control system can include a quality check insert having optical properties. In an embodiment, the insert is placed within a sensor, irradiated with light, and then the light is detected after attenuation by the insert. The detected light is processed using the same or different processing methodologies typically used to determine measurement values for physiological parameters of a monitored patient. When a patient monitor is functioning properly, the results of the processing provide values within a predetermined range of values. When the patient monitor is not functioning properly, the results of the processing provide values outside the predetermined range of values. The quality control system can include quality control parameters indicative of a properly functioning active pulse motor of the sensor, emitters of the sensor, detectors of the sensor, accelerometers of the sensors, and/or temperature sensors of the system.

Abstract translation: 公开了一种患者监护仪的质量控制系统。 质量控制系统可以包括具有光学特性的质量检查插件。 在一个实施例中，将插入物放置在传感器内，用光照射，然后在插入物衰减之后检测光。 使用通常用于确定被监测患者的生理参数的测量值的相同或不同的处理方法来处理检测到的光。 当患者监视器正常工作时，处理结果提供在预定值范围内的值。 当病人监护仪不能正常工作时，处理结果提供超出预定范围值的值。 质量控制系统可以包括指示传感器的正常工作的有源脉冲电机，传感器的发射器，传感器的检测器，传感器的加速度计和/或系统的温度传感器的质量控制参数。

公开(公告)号：US20140275835A1

公开(公告)日：2014-09-18

申请号：US14203243

申请日：2014-03-10

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Marcelo M. Lamego ,  Abraham Mazda Kiani ,  Don Sanders ,  Jeroen Poeze ,  Massi Joe E. Kiani ,  Anthony Amir Davia

IPC: A61B5/00 ,  A61B5/021 ,  A61B5/1455

CPC classification number: A61B5/0022 ,  A61B5/14551 ,  A61B5/7235 ,  G16H50/30

Abstract: A cloud-based physiological monitoring system has a sensor in communications with a living being so as to generate a data stream generally responsive to a physiological condition of the living being. A monitor receives the data stream from the sensor and transmits the data stream to a cloud server. The cloud server processes the data stream so as to derive physiological parameters having values responsive to the physiological condition. The cloud server derives a medical index based upon a combination of the physiological parameters. The cloud server communicates the medical index to the monitor, which displays the medical index.

Abstract translation: 基于云的生理监测系统具有与生活通信的传感器，以便生成一般响应于生活的生理条件的数据流。 监视器从传感器接收数据流，并将数据流发送到云服务器。 云服务器处理数据流，以便导出具有响应于生理条件的值的生理参数。 云服务器根据生理参数的组合导出医学指标。 云服务器将医疗指标传达到监视器，显示医疗指数。

公开(公告)号：US08754776B2

公开(公告)日：2014-06-17

申请号：US13918206

申请日：2013-06-14

Applicant: Cercacor Laboratories, Inc.

Inventor： Jeroen Poeze ,  Jesse Chen ,  Mathew Paul ,  Marcelo Lamego ,  Massi Joe E. Kiani

IPC: G08B21/00

CPC classification number: G01R13/0281 ,  A61B5/0015 ,  A61B5/0261 ,  A61B5/14532 ,  A61B5/14551 ,  A61B5/7203 ,  A61B5/7228 ,  A61B2560/0242 ,  A61B2560/0276 ,  G01R29/0814

Abstract: A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.

Abstract translation: 公开了一种用于检测和计算环境和/或环境噪声的水平的系统，例如由电力线，环境光，光调光器，电视或计算机显示器，电源或变压器和医疗设备产生的电磁干扰。 在一些实施例中，系统对由光检测器检测到的干扰信号进行频率分析，并确定集中在分析频带中的干扰信号的功率。 最坏情况的干扰电平可以通过从计算的功率值中选择最大值来确定。 在一些实施例中，所确定的干扰信号功率可以与被配置为可靠且非侵入地检测用户的生理参数的患者监视系统的噪声容限进行比较。 比较的结果可以直观地呈现给用户。 在一些实施例中，该系统可用于执行电磁干扰的抽查检查测量。

公开(公告)号：US20140155712A1

公开(公告)日：2014-06-05

申请号：US14153895

申请日：2014-01-13

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Marcelo M. Lamego ,  Sean Merritt ,  Cristiano Dalvi ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Massi Joe E. Kiani

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B2562/0233 ,  A61B2562/04 ,  A61B2562/046 ,  A61B2562/146

Abstract: The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled.

Abstract translation: 本公开涉及一种用于非侵入式葡萄糖传感器的接口，其包括适于接收来自光学检测器的输入信号并提供相应数字信号的前端。 在一个实施例中，前端包括能够处理来自光学检测器的多个流信号的开关电容器电路。 在另一个实施例中，前端包括能够处理多个输入信号流的跨阻放大器。 在该实施例中，跨阻抗放大器可以基于其自身的特性，例如其阻抗，与其耦合的光电二极管的阻抗以及与其耦合的光电二极管的数量来配置。

公开(公告)号：US20140114199A1

公开(公告)日：2014-04-24

申请号：US14056615

申请日：2013-10-17

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Hung Vo ,  Cristiano Dalvi ,  Sean Merritt

IPC: A61B5/00 ,  A61B5/024

CPC classification number: A61B5/6838 ,  A61B5/02422 ,  A61B5/14551 ,  A61B5/6826 ,  A61B2562/0238

Abstract: A magnetic-flap optical sensor has an emitter activated so as to transmit light into a fingertip inserted between an emitter pad and a detector pad. The sensor has a detector responsive to the transmitted light after attenuation by pulsatile blood flow within fingertip so as to generate a detector signal. Flaps extend from the emitter pad and along the sides of a detector shell housing the detector pad. Flap magnets are disposed on the flap ends and shell magnets are disposed on the detector shell sides. A spring urges the emitter shell and detector shell together, so as to squeeze the fingertip between its fingernail and its finger pad. The flap magnets have opposite north and south orientations from the shell magnets, urging the flaps to the detector shell sides and squeezing the fingertip sides. These spring and magnet squeezing forces occlude the fingertip blood flow and accentuate a detector signal responsive to an active pulsing of the fingertip.

Abstract translation: 磁瓣光学传感器具有被激活的发射器，以将光透射到插入在发射器焊盘和检测器焊盘之间的指尖中。 传感器具有响应于通过指尖中的脉动血流衰减的透射光的检测器，以便产生检测器信号。 襟翼从发射极焊盘延伸，并沿壳体检测器焊盘的检测器外壳的侧面延伸。 翼片磁体设置在翼片端部，壳体磁铁设置在检测器壳体侧。 弹簧将发射器壳体和探测器壳体一起推动，以将指尖挤压在其指甲和指垫之间。 翼片磁体具有与壳体磁体相反的北和南取向，将翼片推向检测器壳体侧并挤压指尖侧。 这些弹簧和磁铁挤压力阻挡指尖血流，并响应于指尖的主动脉冲强化检测器信号。

公开(公告)号：US20140066783A1

公开(公告)日：2014-03-06

申请号：US14069974

申请日：2013-11-01

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Massi Joe E. Kiani ,  Marcelo Lamego ,  Sean Merritt ,  Cristiano Dalvi ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferydan Lesmana ,  Greg Olsen

IPC: A61B5/024 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/02427 ,  A61B5/02416 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/4875 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B5/70 ,  A61B5/7275 ,  A61B2562/146

Abstract: A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.

Abstract translation: 用于测量医疗患者的一个或多个生理参数的无创生理传感器可以包括插入在光源和光电检测器之间的凸块。 凸起可以放置成与患者的身体组织接触，从而减少身体组织的厚度。 结果，可以减少光源和光电检测器之间的光程。 此外，传感器可以包括可将热量远离光源引导的散热器。 此外，传感器可以包括在光源和光电检测器之间的光路中的屏蔽。 屏蔽可以降低由光电检测器接收的噪声。

公开(公告)号：US20130338461A1

公开(公告)日：2013-12-19

申请号：US13862266

申请日：2013-04-12

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Mohamed Diab ,  Walter M. Weber ,  Ammar Al-Ali ,  Joe Kiani

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/0205

CPC classification number: A61B5/14552 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/72 ,  G01N21/314 ,  G01N21/35 ,  G01N21/359 ,  G01N2201/0627 ,  G01N2201/129

Abstract: A physiological monitor for determining blood oxygen saturation of a medical patient includes a sensor, a signal processor and a display. The sensor includes at least three light emitting diodes. Each light emitting diode is adapted to emit light of a different wavelength. The sensor also includes a detector, where the detector is adapted to receive light from the three light emitting diodes after being attenuated by tissue. The detector generates an output signal based at least in part upon the received light. The signal processor determines blood oxygen saturation based at least upon the output signal, and the display provides an indication of the blood oxygen saturation.

Abstract translation: 用于确定医疗患者的血氧饱和度的生理监测器包括传感器，信号处理器和显示器。 传感器包括至少三个发光二极管。 每个发光二极管适于发射不同波长的光。 传感器还包括检测器，其中检测器适于在被组织衰减之后接收来自三个发光二极管的光。 检测器至少部分地基于所接收的光产生输出信号。 信号处理器至少基于输出信号确定血氧饱和度，并且显示器提供血氧饱和度的指示。