公开(公告)号：US11684296B2

公开(公告)日：2023-06-27

申请号：US16721527

申请日：2019-12-19

Applicant: Cercacor Laboratories, Inc.

Inventor： Hung The Vo ,  Kevin Hughes Pauley ,  Cristiano Dalvi ,  Sean Merritt ,  Jesse Chen ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Ruiqi Long

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0242

Abstract: A noninvasive physiological sensor can include a first body portion and a second body portion coupled to each other and configured to at least partially enclose a user's finger. The sensor can further include a first probe coupled to one or more emitters and a second probe coupled to a detector. The first probe can direct light emitted from the one or more emitters toward tissue of the user's finger and the second probe can direct light attenuated through the tissue to the detector. The first and second probes can be coupled to the first and second body portions such that when the first and second body portions are rotated with respect to one another, ends of the first and second probes can be moved in a direction towards one another to compress the tissue of the user's finger.

公开(公告)号：US11653862B2

公开(公告)日：2023-05-23

申请号：US15160907

申请日：2016-05-20

Applicant: Cercacor Laboratories, Inc.

Inventor： Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Jeroen Poeze ,  Jesse Chen ,  Kevin Hughes Pauley ,  Mathew Paul ,  Sean Merritt ,  Thomas B. Blank ,  Massi Joe E. Kiani

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/0075 ,  A61B5/6838 ,  A61B2562/0238

Abstract: An optical physiological sensor configured to perform high speed spectral sweep analysis of sample tissue being measured to non-invasively predict an analyte level of a patient. An emitter of the optical physiological sensor can be regulated to operate at different temperatures to emit radiation at different wavelengths. Variation in emitter drive current, duty cycle, and forward voltage can also be used to cause the emitter to emit a range of wavelengths. Informative spectral data can be obtained during the sweeping of specific wavelength regions of sample tissue.

公开(公告)号：US20230121602A1

公开(公告)日：2023-04-20

申请号：US18069185

申请日：2022-12-20

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Massi Joe E. Kiani ,  Jeroen Poeze ,  Cristiano Dalvi ,  Sean Merritt ,  Hung Vo ,  Gregory A. Olsen ,  Ferdyan Lesmana

IPC: A61B5/0205 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/1459

Abstract: The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.

公开(公告)号：US20200163597A1

公开(公告)日：2020-05-28

申请号：US16697814

申请日：2019-11-27

Applicant: Cercacor Laboratories, Inc.

Inventor： Cristiano Dalvi ,  Hung The Vo ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Jesse Chen ,  Kevin Hughes Pauley ,  Ruiqi Long ,  Stephen Leonard Monfre ,  Sean Merritt ,  Mohamed K. Diab ,  Massi Joe E. Kiani

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/053 ,  A61B5/01

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.

公开(公告)号：US10729335B2

公开(公告)日：2020-08-04

申请号：US16230734

申请日：2018-12-21

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Massi Joe E. Kiani ,  Jeroen Poeze ,  Cristiano Dalvi ,  Sean Merritt ,  Hung Vo ,  Gregory A. Olsen ,  Ferdyan Lesmana

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/021 ,  A61B5/08

Abstract: The present disclosure includes a handheld processing device including medical applications for minimally and noninvasive glucose measurements. In an embodiment, the device creates a patient specific calibration using a measurement protocol of minimally invasive measurements and noninvasive measurements, eventually creating a patient specific noninvasive glucometer. Additionally, embodiments of the present disclosure provide for the processing device to execute medical applications and non-medical applications.

公开(公告)号：US20150005600A1

公开(公告)日：2015-01-01

申请号：US14210410

申请日：2014-03-13

Applicant: Cercacor Laboratories, Inc.

Inventor： Thomas B. Blank ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt ,  Marcelo M. Lamego

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/6833 ,  A61B5/14532 ,  A61B5/14551 ,  A61B5/6826

Abstract: A finger-placement sensor tape aligns and removably secures a finger to a sensor pad of a reusable finger-clip optical sensor so as to assure the finger is repeatably aligned between the sensors emitters and detectors and that the finger stays aligned during a test procedure. The sensor tape has a double-sided tape layer having a silicon-based adhesive on a finger side and an acrylic adhesive on a sensor-side. An aperture is defined in the tape layer so as to allow emitters disposed in a top sensor pad to emit light through the tape layer to detectors disposed in a bottom sensor pad. A finger-side release layer is removably disposed over the silicon-based adhesive. A sensor-side release layer is removably disposed over the acrylic adhesive.

Abstract translation: 手指放置传感器带将手指对准并可移除地固定到可重复使用的手指夹式光学传感器的传感器垫上，以确保手指在传感器发射器和检测器之间重复对准，并且手指在测试过程中保持对准。 传感带具有在手指侧具有硅基粘合剂的双面胶带层和传感器侧的丙烯酸粘合剂。 在带层中限定孔径，以允许设置在顶部传感器衬垫中的发射器通过带层向发射器发射设置在底部传感器垫中的检测器。 手指侧释放层可移除地设置在硅基粘合剂上。 传感器侧释放层可移除地设置在丙烯酸粘合剂上。

公开(公告)号：US20140051953A1

公开(公告)日：2014-02-20

申请号：US14065226

申请日：2013-10-28

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo Lamego ,  Sean Merritt ,  Massi Joe E. Kiani

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1455

CPC classification number: A61B5/7221 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/742 ,  A61B5/746

Abstract: This disclosure describes, among other features, systems and methods for customizing calibration curves, parameter algorithms, and the like to individual users. An initial calibration curve generated based on a population can be used as a starting point in an algorithm for measuring a physiological parameter such as glucose. The measurement algorithm can determine one or more initial measurement values for a user based on the initial calibration curve. In certain embodiments, one or more alternative measurements, such as invasive or minimally invasive measurements, can periodically or sporadically be input into the measurement algorithm. The algorithm can use the alternative measurements to adapt the calibration curve to the individual. As a result, measurements for the individual can more accurately reflect the individual's actual parameter values.

Abstract translation: 本公开内容还描述了用于将校准曲线，参数算法等定制到个体用户的系统和方法。 基于群体生成的初始校准曲线可以用作用于测量诸如葡萄糖的生理参数的算法中的起始点。 测量算法可以基于初始校准曲线确定用户的一个或多个初始测量值。 在某些实施例中，可以周期地或偶尔地将一个或多个替代测量，例如侵入性或微创测量输入到测量算法中。 该算法可以使用替代测量来将校准曲线适应于个体。 因此，个人的测量可以更准确地反映个人的实际参数值。

公开(公告)号：US11992311B2

公开(公告)日：2024-05-28

申请号：US17324396

申请日：2021-05-19

Applicant: Cercacor Laboratories, Inc.

Inventor： Jesse Chen ,  Sean Merritt ,  Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Kevin Hughes Pauley ,  Jeroen Poeze ,  Ruiqi Long ,  Stephen L Monfre

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/0531 ,  A61B5/107 ,  A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/0205 ,  A61B5/7203 ,  A61B5/7278 ,  A61B5/0066 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/0531 ,  A61B5/1075 ,  A61B5/1079 ,  A61B5/14551 ,  A61B5/442 ,  A61B5/443 ,  A61B2560/0223 ,  A61B2576/02

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

公开(公告)号：US20210378562A1

公开(公告)日：2021-12-09

申请号：US17324396

申请日：2021-05-19

Applicant: Cercacor Laboratories, Inc.

Inventor： Jesse Chen ,  Sean Merritt ,  Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Kevin Hughes Pauley ,  Jeroen Poeze ,  Ruiqi Long ,  Stephen L. Monfre

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/0205

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

公开(公告)号：US11026604B2

公开(公告)日：2021-06-08

申请号：US16034743

申请日：2018-07-13

Applicant: Cercacor Laboratories, Inc.

Inventor： Jesse Chen ,  Sean Merritt ,  Cristiano Dalvi ,  Ferdyan Lesmana ,  Hung The Vo ,  Kevin Hughes Pauley ,  Jeroen Poeze ,  Ruiqi Long ,  Stephen L. Monfre

IPC: A61B5/02 ,  A61B5/145 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/0531 ,  A61B5/107 ,  A61B5/1455

Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.