公开(公告)号：US20240409571A1

公开(公告)日：2024-12-12

申请号：US18627308

申请日：2024-04-04

Applicant: The Regents of the University of California

Inventor： Xi CHEN ,  Hai YU ,  Bijoyananda MISHRA ,  Zimin ZHENG ,  Anand Kumar AGRAHARI ,  Arin GUCCHAIT

IPC: C07H15/12 ,  C07H1/00 ,  C12P13/00

Abstract: Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.

公开(公告)号：US12164011B2

公开(公告)日：2024-12-10

申请号：US17602926

申请日：2020-04-15

Applicant: The Regents of the University of California

Inventor： Holden H. Wu ,  Le Zhang ,  Tess Armstrong

IPC: G01R33/48 ,  A61B5/00 ,  A61B5/01 ,  A61B5/055 ,  G01R33/50 ,  G01R33/54 ,  G01R33/561

Abstract: A method for proton resonance frequency shift (PRF) and T1-based temperature mapping using a magnetic resonance imaging (MRI) system includes acquiring, using the MRI system, a set of magnetic resonance (MR) data from a region of interest of a subject by performing a variable-flip-angle multi-echo gradient-echo 3D stack-of-radial pulse sequence. The pulse sequence is configured to acquire radial k-space data in a plurality of segments, each segment acquired with each of a plurality of flip angles. The method further includes generating at least one T1 map based on the set of MR data, generating at least one PRF temperature map based on the set of MR data, generating at least one T1-based temperature map based on the set of MR data and displaying the PRF temperature map and the T1-based temperature map. In another embodiment, the MR data may be used to generate a plurality of quantitative parameter maps for each of the plurality of MR parameters such as T1, proton-density fat fraction (PDFF), and R2*.

公开(公告)号：US12161972B2

公开(公告)日：2024-12-10

申请号：US17873953

申请日：2022-07-26

Applicant: The Regents of the University of California

Inventor： Gaurav Sant ,  Erika Callagon La Plante ,  Jingbo Wang ,  David Jassby ,  Dante Simonetti ,  Abdulaziz Alturki ,  Xin Chen

IPC: B01D53/62 ,  B01D53/78 ,  B01D53/96 ,  C01B13/36 ,  C01B32/60 ,  C02F1/461 ,  C02F103/08 ,  C02F103/18

Abstract: Provided herein are methods of removing carbon dioxide from an aqueous stream or gaseous stream by: contacting the gaseous stream comprising carbon dioxide, when present, with an aqueous solution comprising ions capable of forming an insoluble carbonate salt; contacting the aqueous solution comprising carbon dioxide with an electroactive mesh that induces its alkalinization thereby forcing the precipitation of a carbonate solid from the solution and thereby the removal of dissolved inorganic carbon by electrolysis; and removing the precipitated carbonate solids from the solution, or the surface of the mesh where they may deposit. Also provided herein are flow-through electrolytic reactors comprising an intake device in fluid connection with a rotating cylinder comprising an electroactive mesh, and a scraping device and/or liquid-spray based device for separating a solid from the mesh surface.

公开(公告)号：US20240405259A1

公开(公告)日：2024-12-05

申请号：US18661381

申请日：2024-05-10

Applicant: LG ENERGY SOLUTION, LTD. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ping LIU ,  Junghwa HONG ,  Mengchen LIU ,  Jeong Woo OH ,  Ke ZHOU

IPC: H01M10/056

Abstract: Disclosed is a coated sulfide-containing solid electrolyte material, as well as a solid electrolyte thereof, and a solid state battery containing a solid electrolyte thereof. According to aspects of the disclosure, the coating is formed on the surface of a sulfide-containing solid electrolyte material, and includes a compound having a thiol with a long hydrophobic tail, e.g., such as 1-undecanethiol. The coating may provide protection from air and moisture, for instance, under ambient conditions.

公开(公告)号：US20240400985A1

公开(公告)日：2024-12-05

申请号：US18563301

申请日：2022-06-14

Applicant: The Regents of the University of California ,  CZ Biohub SF, LLC

Inventor： Mohammed Andres Mostajo Radji ,  Alexander A. Pollen

IPC: C12N5/0793

Abstract: The present disclosure provides a method of generating an enriched population of parvalbumin-positive interneurons. The present disclosure provides a chimeric organoid comprising an enriched population of parvalbumin-positive interneurons. The present disclosure provides methods of identifying agents that modulate a feature of a parvalbumin-positive interneuron.

公开(公告)号：US20240399367A1

公开(公告)日：2024-12-05

申请号：US18680555

申请日：2024-05-31

Applicant: The Regents of the University of California

Inventor： Tien-Chieh HUNG ,  Stephany Aguayo URIBE ,  Steven NGUYEN

IPC: B01L3/00

Abstract: According to one embodiment of the present disclosure, devices, systems, and methods for separating irregular particles by size. A fluidic device for zooplankton separation includes at least one inlet and a curvilinear channel having multiple sub-outlet divisions arranged along a fluidic path of the fluidic device. The multiple sub-outlet divisions include at least two first sub-outlets and at least four second sub-outlets. The least two second sub-outlets extend from each of the at least two first sub-outlets. A method of separating zooplankton includes introducing a mixture including irregular particles into at least one inlet of a micro-fluidic device. The method further includes guiding the mixture including the irregular particles through a curvilinear microchannel of the device. The method includes separating larger and smaller particles based on inertial forces between two first sub-outlets and separating larger and smaller particles from a pre-separated fluid between two second sub-outlets.

公开(公告)号：US20240399041A1

公开(公告)日：2024-12-05

申请号：US18605528

申请日：2024-03-14

Applicant: The Regents of the University of California ,  Vanderbilt University

Inventor： Shuvo Roy ,  William Fissell ,  Nathan Wright ,  Mark Goodin ,  Steven G. Goebel ,  Amanda Buck ,  Joey Groszek

IPC: A61M1/34 ,  A61M1/16 ,  A61M5/165 ,  B01D63/08 ,  F28F9/02

Abstract: Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

公开(公告)号：US12159929B1

公开(公告)日：2024-12-03

申请号：US17114307

申请日：2020-12-07

Applicant: The Regents of the University of California

Inventor： Stacia Keller ,  Umesh K. Mishra

IPC: H01L29/778 ,  H01L29/10 ,  H01L29/15 ,  H01L29/20 ,  H01L29/205 ,  H01L29/66

Abstract: An electronic device including a substrate a group III-V layer on or above the substrate, wherein the III-V layer has an in-plane lattice constant that is greater than that of gallium nitride or wherein the III-V layer is at least partially relaxed; and an active region including a coherently strained group III-V channel layer on or above the III-V layer; wherein electron mobility in the channel layer is increased by the strain. Structures with an in-plane lattice constant that is smaller than that of gallium nitride are used for increasing the hole mobility by strain.

公开(公告)号：US12158422B2

公开(公告)日：2024-12-03

申请号：US18214292

申请日：2023-06-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric D. Diebold ,  Bahram Jalali ,  Brandon Buckley

IPC: G01N21/64 ,  G01N21/05 ,  G02B21/00 ,  G02B21/16 ,  G02B27/10 ,  G02F1/11

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

公开(公告)号：US12158421B2

公开(公告)日：2024-12-03

申请号：US17745206

申请日：2022-05-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric D. Diebold ,  Bahram Jalali ,  Brandon Buckley

IPC: G01N21/64 ,  G01N21/05 ,  G02B21/00 ,  G02B21/16 ,  G02B27/10 ,  G02F1/11

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.