公开(公告)号：US09059408B2

公开(公告)日：2015-06-16

申请号：US13668334

申请日：2012-11-05

Applicant: Academia Sinica

Inventor： Ta-Hsin Chow ,  Motonori Watanabe ,  Yuan Jay Chang ,  Yu-Tai Tao ,  Ting-Han Chao ,  Shun-Wei Liu ,  Chih-Hsien Yuan ,  Teruo Shinmyozu ,  Kenta Goto ,  Md.Minarul Islam

IPC: H01B1/12 ,  C07C15/00 ,  C07C15/20 ,  H01L51/00 ,  C07C1/207 ,  H01L51/05

CPC classification number: H01L51/0026 ,  C07C1/2076 ,  C07C2603/54 ,  H01L51/0056 ,  H01L51/0558 ,  C07C15/20

Abstract: A hexacene derivative is described, being expressed by formula (1): wherein X1-X6 denote the presence or absence of a carbonyl bridge [—C(═O)—], with a proviso that at least one of X1-X6 is a carbonyl bridge while any six-member ring absent of a carbonyl bridge is aromatic. A method for forming hexacene is also described, including: thermally treating the hexacene derivative to expel volatile units of CO from the hexacene derivative.

Abstract translation: 描述了通过式（1）表示的并六苯衍生物：其中X1-X6表示羰基桥[-C（= O） - ]的存在或不存在，条件是X 1 -X 6中的至少一个为 羰基桥，而没有羰基桥的任何六元环是芳香族的。 还描述了形成并六苯的方法，包括：热处理并六苯衍生物以从己烯衍生物中排出CO的挥发性单元。

公开(公告)号：US20150148360A1

公开(公告)日：2015-05-28

申请号：US14416051

申请日：2013-07-19

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Jung-Hsin Lin ,  Jim-Min Fang ,  Ting-Rong Chen ,  Jhih-Bin Chen ,  Ching-Chow Chen ,  Tzu-Tang Wei

IPC: C07D215/14 ,  C07D209/24 ,  C07D213/56 ,  C07D207/34 ,  C07D239/42 ,  A61K45/06 ,  A61K31/4045 ,  A61K31/47 ,  A61K31/44 ,  A61K31/401 ,  A61K31/505 ,  C07C259/06 ,  A61K31/221

CPC classification number: C07D215/14 ,  A61K31/221 ,  A61K31/401 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K45/06 ,  C07B2200/07 ,  C07C259/06 ,  C07C259/08 ,  C07C2602/28 ,  C07D207/34 ,  C07D209/24 ,  C07D213/56 ,  C07D239/42

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds and pharmaceutical compositions for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, and a disease associated with oxidative stress), or inhibiting drug resistance of cancer cells.

Abstract translation: 本发明提供新的式（I）化合物及其药物组合物。 式（I）化合物是组蛋白脱乙酰酶（HDAC）和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶（HMGR）的抑制剂。 还提供了使用化合物和药物组合物来抑制HDAC和HMGR的活性，治疗与HDAC或HMGR相关的疾病（例如癌症，高胆固醇血症，急性或慢性炎性疾病，自身免疫性疾病，过敏性疾病，病原体感染， 神经变性疾病和与氧化应激相关的疾病），或抑制癌细胞的耐药性。

公开(公告)号：US20150126583A1

公开(公告)日：2015-05-07

申请号：US14534466

申请日：2014-11-06

Applicant: ACADEMIA SINICA

Inventor： FU-TONG LIU ,  WEI-CHEN HSIEH ,  RI-YAO YANG

IPC: C12N15/113 ,  C12N15/115

CPC classification number: C12N15/113 ,  C12N2310/14

Abstract: Methods for the treatment of a disorder characterized by excessive proliferation and/or lipid content of sebocytes are disclosed. In one embodiment of the invention, the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a small molecule inhibitor targeted to galectin-12 or a nucleic acid-based inhibitor targeted to galectin-12 and a pharmaceutically acceptable carrier, wherein said inhibitor is a non-naturally occurring molecule and administration of said inhibitor produces a decrease in the proliferation and/or lipid content of the sebocytes. Methods for decreasing sebaceous gland size, inhibiting sebocyte proliferation, and/or inhibiting sebocyte lipid content are also disclosed.

Abstract translation: 公开了治疗以皮脂细胞过度增殖和/或脂质含量为特征的病症的方法。 在本发明的一个实施方案中，所述方法包括向有需要的受试者施用治疗有效量的药物组合物，其包含靶向半乳凝素-12的小分子抑制剂或靶向半乳凝素-12的核酸抑制剂和药学上 其中所述抑制剂是非天然存在的分子，并且所述抑制剂的施用会导致皮脂细胞的增殖和/或脂质含量的降低。 还公开了降低皮脂腺体积大小，抑制血细胞增殖和/或抑制血细胞脂质含量的方法。

公开(公告)号：US20150101936A1

公开(公告)日：2015-04-16

申请号：US14509509

申请日：2014-10-08

Applicant: Academia Sinica

Inventor： MING-HSI CHIANG ,  YU-CHIAO LIU ,  KAI-TI CHU

IPC: B01J31/22 ,  C25B1/02 ,  C07F15/02

CPC classification number: B01J31/226 ,  B01J2231/60 ,  B01J2531/842 ,  C07F15/02 ,  C25B1/02 ,  H01M8/0656

Abstract: This invention relates to an iron-sulfur complex that is capable of efficiently catalyzing formation of hydrogen, and a method for producing hydrogen using the complex as a catalyst. The iron-sulfur complex provided herein comprises: a structure of formula (I) wherein the ligands L1 to L3, L5 and L6 and the groups X1 to X3 are each selected from the group consisting of alkyl, alkenyl, alkynyl and aryl that are substituted or unsubstituted, hydroxyl, carbonyl, aldehyde, and so on; L4 is a bridging ligand selected from the group consisting of hydroxyl, carbonyl, and so on; and the symbol “z” means the charge, which is an integer with the range of −3 to +2. X1 and X2 may join together to form a bridging group between the two sulfur atoms. X3 may alternatively be a vacant site.

Abstract translation: 本发明涉及能够有效地催化氢的形成的铁 - 硫络合物，以及使用该络合物作为催化剂生产氢的方法。 本文提供的铁 - 硫络合物包括：式（I）的结构，其中配体L1至L3，L5和L6以及基团X1至X3各自选自被取代的烷基，烯基，炔基和芳基 或未取代的羟基，羰基，醛等; L4是选自羟基，羰基等的桥连配体; 符号“z”表示电荷，其为-3至+2范围内的整数。 X1和X2可以连接在一起以在两个硫原子之间形成桥连基团。 X3可以替代地是空的站点。

公开(公告)号：US20150038445A1

公开(公告)日：2015-02-05

申请号：US14378013

申请日：2013-02-11

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Yun-Lian Lin ,  Jim-Min Fang ,  Yijuang Chern ,  Chia-Ching John Lin ,  Wei-Nan Chen ,  Chun-Jung Lin

IPC: A61K31/7076 ,  A61K36/8988

CPC classification number: A61K31/7076 ,  A61K36/8988 ,  A61K45/06 ,  A61K2300/00

Abstract: The disclosure provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

Abstract translation: 本公开提供了腺苷类似物用于通过激活神经激肽1（NK1）受体信号传导途径治疗疼痛的新用途，从而诱导M型钾通道的活化以诱导外向电流。 还提供了一种用于治疗疼痛的方法和药物组合物，其包含激活NK1受体信号传导的腺苷类似物，从而诱导外向电流。

公开(公告)号：US20140298534A1

公开(公告)日：2014-10-02

申请号：US14106350

申请日：2013-12-13

Applicant: Academia Sinica

Inventor： Kuo-Chen YEH ,  Lung-Jiun SHIN

IPC: C12N15/82

CPC classification number: C12N15/8271 ,  C07K14/415 ,  C12N15/8259

Abstract: The present invention relates to a transgenic plant overexpressing an antioxidant protein 1 (ATX1)-like polypeptide, which exhibits resistance to excess or deficiency of copper. The present invention also relates to a method of phytoremediation of an environment contaminated with copper by growing a transgenic plant overexpressing an ATX1-like polypeptide in the environment.

Abstract translation: 本发明涉及过表达抗氧化蛋白1（ATX1）样多肽的转基因植物，其表现出对铜过量或不足的抗性。 本发明还涉及通过在环境中生长过表达ATX1样多肽的转基因植物，来污染铜的环境的植物修复方法。

公开(公告)号：US20140204776A1

公开(公告)日：2014-07-24

申请号：US13900637

申请日：2013-05-23

Applicant: Academia Sinica

Inventor： Kate Ching-Ju Lin ,  Wei-Liang Shen ,  Shyamnath Gollakota ,  Dina Katabi

IPC: H04L1/00

CPC classification number: H04L1/0002 ,  H04B7/0452 ,  H04L1/0015 ,  H04L1/06

Abstract: Dynamic adaption of transmission rate for multiuser MIMO networks is disclosed. The invention controls a first communication device to transmit data at rates optimal determined under the condition that the channel is occupied by the first communication device, a second communication device to transmit data at rates optimal determined under the condition that the channel is shared by the first and second communication devices and a third communication to transmit data at rates optimal determined under the condition that the channel is shared by the first, second and third communication device.

Abstract translation: 公开了多用户MIMO网络的传输速率的动态适应性。 本发明控制第一通信设备以在该信道被第一通信设备占用的条件下最佳确定的速率发送数据;第二通信设备，用于以最佳的速率发送数据，该信道在该信道被第一通信设备共享的条件下确定 以及第二通信设备和第三通信，以在由第一通信设备，第二通信设备和第三通信设备共享信道的条件下最佳确定的速率发送数据。

公开(公告)号：US20140201863A1

公开(公告)日：2014-07-17

申请号：US14067317

申请日：2013-10-30

Applicant: Academia Sinica

Inventor： Yi-Fang Tsay ,  Shu-Chun Fan ,  Hui-Yu Chen

IPC: C12N15/82

CPC classification number: C12N15/8243 ,  C07K14/415 ,  C12N15/8261 ,  Y02A40/146

Abstract: The present invention provides a method for changing nitrogen utilization efficiency in a plant comprises regulating the expression of Arabidopsis NRT 1.7 or an orthologue thereof so that the nitrate remobilization from older leaves to young leaves in the plant is regulated, thereby the nitrogen utilization efficiency is changed. The present invention also provides a transgenic plant obtainable by transforming a plant with an expression construct with a high or low level of expression of NRT 1.7. On the other hand, the present invention yet provides a chimera nitrate transporter, a DNA molecule coding for this chimera transporter and an expression vector thereof.

Abstract translation: 本发明提供一种改变植物氮利用效率的方法，包括调节拟南芥NRT 1.7或其直向同源物的表达，从而调节植物中从老叶到幼叶的硝酸盐再生，从而改变氮利用效率 。 本发明还提供了通过用具有高或低水平的NRT1.7表达的表达构建体转化植物可获得的转基因植物。 另一方面，本发明还提供了嵌合体硝酸盐转运蛋白，编码该嵌合体转运蛋白的DNA分子及其表达载体。

公开(公告)号：US20140142000A1

公开(公告)日：2014-05-22

申请号：US14059297

申请日：2013-10-21

Applicant: Academia Sinica

Inventor： Yi-Chung Tung ,  Chien-Chung Peng ,  Hsiu-Chen Shih ,  Wei-Hao Liao

IPC: G01N33/50

CPC classification number: G01N33/5011 ,  C12M23/16 ,  C12M25/04 ,  C12M41/32

Abstract: The present invention relates to a microfluidic array platform comprising a substrate and two layers between which one membrane is sandwiched, wherein a plurality of cell culture wells are constructed in the top layer and one or more microfluidic channels for oxygen scavenging reactions or/and oxygen generating reactions to control the oxygen tensions are constructed in the bottom player. The microfluidic array platform is capable of simultaneously performing cell culture under different oxygen tensions and compatible with existing cell incubators and high-throughput instruments for cost-effective setup and straightforward operation.

Abstract translation: 微流体阵列平台本发明涉及一种微流体阵列平台，其包括基底和两层之间夹在一个膜之间，其中在顶层中构建多个细胞培养孔，以及一个或多个微流体通道进行氧清除反应或/和产生氧 控制氧气紧张的反应是在底层玩家中构建的。 微流体阵列平台能够在不同的氧气张力下同时进行细胞培养，并与现有的细胞培养箱和高通量仪器兼容，具有成本效益的设置和直接的操作。

公开(公告)号：US20140120522A1

公开(公告)日：2014-05-01

申请号：US14048539

申请日：2013-10-08

Applicant: Academia Sinica

Inventor： Chia-Fu Chou ,  K.K. Sriram

IPC: C12Q1/70

CPC classification number: B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0822 ,  B01L2400/0415 ,  Y10T29/49117

Abstract: A device for optical mapping of protein binding sites, in particular, transcription factor binding sites, on single DNA molecules, includes an insulating substrate having two parallel channels and at least one slit connecting the two channels, a coverslip on the substrate, at least two reservoirs on the substrate connecting the channels of the insulating substrate, and at least two electrodes in the reservoirs. When the reservoirs are filled with a buffer solution, the electrodes are in electrical contact in the buffer solution.

Abstract translation: 用于在单个DNA分子上的蛋白质结合位点，特别是转录因子结合位点的光学映射的装置包括具有两个平行通道的绝缘基底和连接两个通道的至少一个狭缝，在基底上的盖玻片，至少两个 连接绝缘基板的通道的基板上的储存器和储存器中的至少两个电极。 当储存器填充缓冲溶液时，电极在缓冲溶液中电接触。