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公开(公告)号：US10882737B2
公开(公告)日：2021-01-05
申请号：US16088021
申请日：2017-03-23
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Navab Singh , Daw Don Cheam
Abstract: A through silicon interposer wafer and method of manufacturing the same. A through silicon interposer wafer having at least one cavity formed therein for MEMS applications and a method of manufacturing the same are provided. The through silicon interposer wafer includes one or more filled silicon vias formed sufficiently proximate to the at least one cavity to provide support for walls of the at least one cavity during subsequent processing of the interposer wafer.
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公开(公告)号：US10881677B2
公开(公告)日：2021-01-05
申请号：US15770437
申请日：2016-10-24
Applicant: Agency for Science, Technology and Research
Inventor： Qiang Yu , Zhen Ning Wee
IPC: A61K31/704 , C12Q1/6886 , A61P35/00 , G01N33/574
Abstract: The present invention relates to the treatment of breast cancer, more particularly triple negative breast cancer (TNBC), with the use of an inhibitor of Interleukin 1 Receptor Associated Kinase 1 (IRAK1) such as ginsenosides. It also relates to a method for aiding in categorising or determining prognosis in a breast cancer patient or in selecting a therapeutic strategy comprising assessing the level of IRAK1 nucleic acid, protein or activity in a sample and, in some aspects, further assessing the paclitaxel resistance status of the patient and if the patient is resistant to paclitaxel therapy, treating the patient with an inhibitor of IRAK1 activity. In addition, a screening method for identifying a compound useful for treating breast cancer comprises determining the effect of a test compound on IRAK1 nucleic acid, protein or activity level and selecting a compound that reduces said level.
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公开(公告)号：US20200367756A1
公开(公告)日：2020-11-26
申请号：US16960306
申请日：2019-01-14
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Kapil Dev , Dinish Unnimadhava Kurup Soudamini Amma , Renzhe Bi
Abstract: Provided are a system and a method for in vivo detection of adipose tissue browning. The system includes a fiber probe configured to illuminate light on an adipose tissue site; a spectrometer configured to obtain diffuse reflectance spectrum information from the adipose tissue site; a chromophore measure determining module configured to determine a fraction of lipid chromophore with respect to lipid chromophore and water chromophore based on spectrally unmixing the diffuse reflectance spectrum information in a region of 1050 nm to 1400 nm; and a browning detector module configured to detect adipose tissue browning based on the fraction determined above.
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公开(公告)号：US20200345782A1
公开(公告)日：2020-11-05
申请号：US16875486
申请日：2020-05-15
Applicant: Agency for Science, Technology and Research
Inventor： Lawrence Stanton , Padmapriya Sathiyanathan , Simon Cool , Victor Nurcombe , Rebekah M. Samsonraj
IPC: A61K35/28 , C12Q1/6881 , A61K35/545 , C12N5/0775
Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
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公开(公告)号：US10819366B1
公开(公告)日：2020-10-27
申请号：US16305142
申请日：2017-05-24
Inventor： Neelakantan Narasimman , Dipankar Nag , Kevin Tshun Chuan Chai , Tae Hyoung Kim
Abstract: Various embodiments may provide a delta sigma modulator for generating a digital output voltage. The delta sigma modulator may include a capacitance-to-voltage converter for converting a sensed continuous-in-time applied capacitance signal to a delta analog output voltage signal. The modulator may also include an integrator circuit arrangement configured to generate an analog output voltage signal based on the delta analog output voltage signal. The modulator may additionally include a quantizer circuit arrangement configured to generate the digital output signal based on the analog output voltage signal. The modulator may further include a voltage digital-to-analog converter configured to generate the analog charging voltage based on the digital output signal, thereby generating the delta analog output voltage signal based on the digital output signal.
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Patent Agency Ranking
146.发明申请公开(公告)号：US20200330943A1
公开(公告)日：2020-10-22
申请号：US16756612
申请日：2018-10-23
Applicant: Agency for Science, Technology and Research
Inventor： Dmitry Isakov , Siew Soon Vong , Huang Ming Chong , Stefanie Feih
Abstract: Various embodiments may provide an apparatus for maintaining a pressure different from atmospheric pressure. The apparatus may include a plurality of structural members coupled together to at least partially define a space which is configured to have a pressure different from atmospheric pressure, a structural member of the plurality of structural members being a support structure having an array of holes. The apparatus may also include a film covering a surface of the support structure having an array of holes. The film maybe adapted to allow a predetermined range of wavelengths of electromagnetic waves to pass through.
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147.发明授权公开(公告)号：US10809430B2
公开(公告)日：2020-10-20
申请号：US16071454
申请日：2016-12-15
Applicant: Agency for Science, Technology and Research
Inventor： Arseniy Kuznetsov , Ramon Jose Paniagua Dominguez
Abstract: Various embodiments may provide a polarization device for polarizing electromagnetic waves. The polarization device may include a stacked arrangement including a medium and an anti-reflection coating in contact with the medium. The polarization device may also include a periodic array of polarization elements in contact with the medium. The polarization device may be configured to, based on an electric response and a magnetic response of the periodic array of the polarization elements, transmit first polarized electromagnetic waves having a first polarization and reflect second polarized electromagnetic waves having a second polarization upon receiving the electromagnetic waves.
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公开(公告)号：US20200328757A1
公开(公告)日：2020-10-15
申请号：US16305142
申请日：2017-05-24
Inventor： Neelakantan Narasimman , Dipankar Nag , Kevin Tshun Chuan Chai , Tae Hyoung Kim
Abstract: Various embodiments may provide a delta sigma modulator for generating a digital output voltage. The delta sigma modulator may include a capacitance-to-voltage converter for converting a sensed continuous-in-time applied capacitance signal to a delta analog output voltage signal. The modulator may also include an integrator circuit arrangement configured to generate an analog output voltage signal based on the delta analog output voltage signal. The modulator may additionally include a quantizer circuit arrangement configured to generate the digital output signal based on the analog output voltage signal. The modulator may further include a voltage digital-to-analog converter configured to generate the analog charging voltage based on the digital output signal, thereby generating the delta analog output voltage signal based on the digital output signal.
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公开(公告)号：US20200311544A1
公开(公告)日：2020-10-01
申请号：US16651637
申请日：2017-09-28
Applicant: Agency for Science, Technology and Research
Inventor： Savitha Ramasamy , Rajaraman Kanagasabai
Abstract: A method, a computer-readable medium, and an apparatus for feature learning are provided. The apparatus may receive a data sample as an input to a feature learning model. The apparatus may calculate a reconstruction error based on the data sample and a plurality of features of the feature learning model. The apparatus may determine whether the reconstruction error satisfies a first threshold. The apparatus may add a feature into the feature learning model to represent the data sample if the data sample satisfies the first threshold. The apparatus may determine whether the reconstruction error satisfies a second threshold. The apparatus may ignore the data sample if the reconstruction error satisfies the second threshold. The apparatus may update the weights associated with the plurality of features of the feature learning model if the reconstruction error satisfies neither the first threshold nor the second threshold.
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公开(公告)号：US10787483B2
公开(公告)日：2020-09-29
申请号：US16038603
申请日：2018-07-18
Applicant: Agency for Science, Technology and Research
Inventor： Brian Cheng San Chia
IPC: A61K38/06 , C07K5/087 , C07K5/117 , C07K1/00 , C07K1/06 , C07K1/10 , C07K5/02 , C07K5/065 , C07K5/072 , A61K38/00
Abstract: The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L1, L2, L3, R1, R2, R3, R4, R5, R6, n, m, Q, X, Z1 and Z2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.
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