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公开(公告)号：US20080287550A1
公开(公告)日：2008-11-20
申请号：US12151081
申请日：2008-05-02
IPC分类号： A61K31/135 , C07C211/19 , A61P25/24
CPC分类号： C07C209/68 , C07B2200/13 , C07C209/84 , C07C211/42 , C07C2602/10 , C07C2602/28 , C07C211/62
摘要： The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be produced from sertraline hydrochloride solvate and hydrate forms, and crystallized from new solvent systems. Pharmaceutical compositions containing sertraline hydrochloride Form II and methods of treatment using such pharmaceutical compositions are also disclosed.
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公开(公告)号：US20080234504A1
公开(公告)日：2008-09-25
申请号：US11998825
申请日：2007-11-30
申请人： Evgeny Tsiperman , Sofia Gorohovsky , Slavik Yurkovski , Sergei Fine , Tamas Koltai , Judith Aronhime
发明人： Evgeny Tsiperman , Sofia Gorohovsky , Slavik Yurkovski , Sergei Fine , Tamas Koltai , Judith Aronhime
IPC分类号： C07C237/26
CPC分类号： C07C237/26
摘要： The present invention provides substantially pure intermediates, 9-haloacetomidominocyclines, and process of preparing them that are useful for the preparation of glycylcyclines, specifically Tigecycline.
摘要翻译： 本发明提供基本上纯的中间体9-卤代酯基咪唑啉环，以及制备它们的方法，其可用于制备甘氨酰环素，特别是替加环素。
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143.发明申请Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel process for preparing other forms 审中-公开阿伐他汀半钙的新型晶体形式及其制备方法以及制备其他形式的新方法公开(公告)号：US20080214650A1
公开(公告)日：2008-09-04
申请号：US11977387
申请日：2007-10-23
IPC分类号： A61K31/401 , C07D207/34
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
摘要翻译： 本发明提供命名为形式VI，VIII，IX，X，XI和XII的阿托伐他汀的新形式及其制备方法以及制备阿托伐他汀形式I，II，IV，V和无定形阿托伐他汀的方法。
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公开(公告)号：US07411075B1
公开(公告)日：2008-08-12
申请号：US09714351
申请日：2000-11-16
申请人： Ari Ayalon , Michal Levinger , Sofia Roytblat , Valerie Niddam , Revital Lifshitz , Judith Aronhime
发明人： Ari Ayalon , Michal Levinger , Sofia Roytblat , Valerie Niddam , Revital Lifshitz , Judith Aronhime
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： The present invention relates to atorvastatin calcium, a useful agent for lowering serum cholesterol levels. New atorvastatin calcium Form V, processes for preparing the new form, and pharmaceutical compositions and dosage forms containing the new form are disclosed.
摘要翻译： 本发明涉及阿托伐他汀钙，其是降低血清胆固醇水平的有用试剂。 公开了新的阿托伐他汀钙V型，制备新型的方法，以及含有新形式的药物组合物和剂型。
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145.发明申请Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof 审中-公开盐酸文拉法辛的结晶文拉法辛碱和新型多晶型物，其制备方法公开(公告)号：US20080167498A1
公开(公告)日：2008-07-10
申请号：US12075875
申请日：2008-03-13
IPC分类号： C07C215/00
CPC分类号： C07C217/74 , C07C213/10 , C07C2601/14
摘要： The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
摘要翻译： 本发明涉及新型基本纯粹的文拉法辛及其制备方法。 本发明还涉及文拉法辛盐酸盐的新型溶剂合物形式及其制备方法。 此外，本发明提供了从文拉法辛制备盐酸文拉法辛的新方法; 该方法包括以下步骤：i）制备文拉法辛与丙酮的混合物; 和ii）将混合物暴露在气态盐酸中。
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公开(公告)号：US20080097096A1
公开(公告)日：2008-04-24
申请号：US12002069
申请日：2007-12-14
申请人： Sandor Molnar , Csaba Szabo , Tivadar Tamas , Janos Hajko , Adrienne Kovacsne-Mezei , Judith Aronhime
发明人： Sandor Molnar , Csaba Szabo , Tivadar Tamas , Janos Hajko , Adrienne Kovacsne-Mezei , Judith Aronhime
IPC分类号： C07D413/02
CPC分类号： C07D307/83 , A61K31/365 , C07D307/88
摘要： Provided are crystalline mycophenolate sodium forms and processes for their preparation.
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公开(公告)号：US20080091018A1
公开(公告)日：2008-04-17
申请号：US11999339
申请日：2007-12-04
IPC分类号： C07D417/14
CPC分类号： C07D417/12
摘要： Provided is a crystalline form of ziprasidone base and processes for its preparation.
摘要翻译： 提供齐拉西酮碱的结晶形式及其制备方法。
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公开(公告)号：US20080091017A1
公开(公告)日：2008-04-17
申请号：US11999294
申请日：2007-12-04
IPC分类号： C07D417/02
CPC分类号： C07D417/12
摘要： Provided is a crystalline form of ziprasidone base and processes for its preparation.
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149.发明申请Crystalline forms of pemetrexed diacid and processes for the preparation thereof 有权培美曲塞二酸的结晶形式及其制备方法公开(公告)号：US20080045711A1
公开(公告)日：2008-02-21
申请号：US11893212
申请日：2007-08-14
申请人： Jonathan Busolli , Nicola Diulgheroff , Csilla Nemethne Racz , Moran Pirkes , Alessandro Pontiroli , Marco Villa , Judith Aronhime
发明人： Jonathan Busolli , Nicola Diulgheroff , Csilla Nemethne Racz , Moran Pirkes , Alessandro Pontiroli , Marco Villa , Judith Aronhime
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
摘要翻译： 提供的是N- [4- [2-（2-氨基-4,7-二氢-4-氧代-1H-吡咯并[2,3-d]嘧啶-5-基）乙基]苯甲酰基] -L- 谷氨酸，培美曲塞二酸及其制备方法。
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公开(公告)号：US20080021244A1
公开(公告)日：2008-01-24
申请号：US11827481
申请日：2007-07-11
申请人： Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人： Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号： C07C213/00
CPC分类号： C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要： The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
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