公开(公告)号：US20170202741A1

公开(公告)日：2017-07-20

申请号：US15410762

申请日：2017-01-19

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/20

Abstract: Connector assembly including a piercing member having a flow port therein attached to a first piece, with the piercing member slidingly receivable within a second piece, wherein the piercing member and the second pierce are movable relative to each other between a first position where the second pieces closes the flow port and a second position where the flow port is open. The first piece contains a locking mechanism that lockingly engages with a device when connected thereto, preventing subsequent disconnection of first piece and the device. Upon initial connection of the first piece to the device, the second piece is moved from the first position to the second position.

公开(公告)号：US09440773B2

公开(公告)日：2016-09-13

申请号：US13572310

申请日：2012-08-10

Applicant: Daniel Py ,  Julian V. Chan ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Julian V. Chan ,  Giovanni Rodriguez

IPC: B67C3/00 ,  B65D35/28 ,  A45D34/04 ,  A45D34/00

CPC classification number: B65D35/28 ,  A45D34/04 ,  A45D2034/007 ,  A45D2200/055

Abstract: A dispenser for dispensing a substance, such as a liquid lipstick or other cosmetic, pharmaceutical or cosmeceutical product, has a body with a variable-volume storage chamber for storing the product. A dispensing portion is connected with the body and a one-way valve for dispensing amounts of product therethrough. The dispensing portion defines a compression chamber in fluid communication with the storage chamber for receiving product therefrom, and an outlet aperture coupled in fluid communication with the compression chamber. The one-way valve has a valve seat, and a visco-elastic valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat, and the seam is connectable in fluid communication with the outlet aperture to allow the passage of product through the seam and out of the dispenser. An actuator is drivingly connected to the compression chamber for pressurizing product within the compression chamber and dispensing an amount of product within the compression chamber.

Abstract translation: 用于分配物质的分配器，例如液体口红或其它化妆品，药​​物或药妆产品，具有具有用于存储产品的可变容积储存室的主体。 分配部分与主体连接，单向阀用于分配产品的数量。 分配部分限定与储存室流体连通的压缩室，用于从其中接收产品，以及与压缩室流体连通的出口孔。 单向阀具有阀座和安置在阀座上的粘弹性阀盖，并且在其间形成常闭的轴向延伸的接缝，形成在阀盖和阀座之间的流体密封。 柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许产品通过接缝并从分配器中通过。 致动器驱动地连接到压缩室，用于对压缩室内的产品进行加压，并且在压缩室内分配一定数量的产品。

公开(公告)号：US20160068283A1

公开(公告)日：2016-03-10

申请号：US14824041

申请日：2015-08-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B3/02 ,  B29C65/00 ,  B65B55/10 ,  B65B55/08 ,  B65B7/16 ,  B29C45/00 ,  B65B3/00

CPC classification number: B65B3/022 ,  B29C45/006 ,  B29C2791/005 ,  B29K2023/00 ,  B29L2031/565 ,  B65B3/003 ,  B65B7/16 ,  B65B51/10 ,  B65B55/08 ,  B65B55/10

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US09222728B2

公开(公告)日：2015-12-29

申请号：US11789498

申请日：2007-04-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: F26B5/06

CPC classification number: F26B5/06

Abstract: A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto. A filter is connectable in fluid communication between an interior and exterior of the chamber for permitting fluid to flow therethrough in a direction from the interior to the exterior of the chamber, and for substantially preventing contaminants from flowing therethrough in a direction from the exterior to the interior of the chamber.

Abstract translation: 提供了一种装置和相关方法，用于冻结装置内的物质并将其中的冻干物质储存在其中。 该装置可以用针将待冷冻干燥的物质填充到装置上，并且通过从激光源发射激光辐射来激光重新密封该装置中的针孔。 该装置限定用于在其中接收待冻干物质的室。 装置的针穿透和可激光重新密封部分可用针刺穿以形成穿过其中的针孔，以通过针将待冷冻干燥的物质填充到腔室中，并且通过施加激光辐射可激光重新密封以密封针孔 。 过滤器可连接在室的内部和外部之间的流体连通中，以允许流体从腔室的内部到外部的方向流过其中，并且用于基本上防止污染物沿着从外部到外部的方向流过 室内

公开(公告)号：USRE45589E1

公开(公告)日：2015-06-30

申请号：US13454853

申请日：2012-04-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B05B11/00

CPC classification number: B05B11/3011 ,  A61F9/0026 ,  A61M11/00 ,  B05B11/3076 ,  B05B11/3092 ,  B05B11/3095

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament. Once the notched lever has extended the front bellows portion a predetermined distance, the notched lever is disengaged from the front bellows portion by the wedge-shaped arm extending from the rear wall of the housing, thereby releasing the front and rear bellows portions, along with the internal piston mechanism, to return to original position and force the medicament from the dosage cavity via a nozzle of the vial-dispenser.

Abstract translation: 药物分配系统包括用于容纳和致动手风琴式小瓶 - 分配器的药筒，用于通过单次致动运动分配校准量的药物，其顺序地加载小瓶分配器并分配装载的药物。 小瓶分配器具有前波纹管部分，后波纹管部分，内部活塞机构，药物储存室和剂量腔。 药筒具有触发器机构，其与位于药筒内部的缺口杠杆和楔形臂协同作用，以顺序地将药物腔装入药物并将其排出。 触发机构的凹陷同时通过切口杆延伸前波纹管部分并压缩后波纹管部分以用药物装载剂量腔。 一旦切口杆将前波纹管部分延伸了预定的距离，则切口杆通过从壳体的后壁延伸的楔形臂与前波纹管部分分离，从而释放前波纹管部分和后波纹管部分以及 内部活塞机构返回到初始位置，并且通过小瓶分配器的喷嘴迫使药物从剂量腔中。

公开(公告)号：US08998034B2

公开(公告)日：2015-04-07

申请号：US12901420

申请日：2010-10-08

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D37/00 ,  F16K15/14 ,  B65B55/08 ,  B29B11/08 ,  B65D83/00 ,  B29B11/14 ,  B29C49/06 ,  B29K23/00 ,  B29K67/00 ,  B29K105/00

CPC classification number: B65D47/2081 ,  B05B11/047 ,  B29B11/08 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14053 ,  B29B2911/14066 ,  B29B2911/1408 ,  B29B2911/14093 ,  B29B2911/14106 ,  B29B2911/14113 ,  B29B2911/14133 ,  B29B2911/1414 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/1442 ,  B29B2911/14473 ,  B29B2911/1452 ,  B29C49/06 ,  B29C73/025 ,  B29K2023/12 ,  B29K2067/00 ,  B29K2105/258 ,  B65B51/023 ,  B65B55/08 ,  B65D51/002 ,  B65D83/0061 ,  F16K15/147 ,  Y10T137/7837

Abstract: A device includes a first part having a co-molded first support, valve cover and elastic actuator, and a second part having an injection molded second support, valve seat, and variable-volume storage chamber pre-form. The pre-form is blow molded into a flexible pouch defining the variable-volume storage chamber. The one-way valve includes a semi-annular, curvilinear, relatively rigid valve seat defining axially-extending, opposing first marginal portions, and an axially-extending first mid-portion angularly extending between the opposing first marginal portions. A flexible valve member is superimposed on the valve seat and defines axially-extending, opposing second marginal portions fixedly secured on or adjacent to respective first marginal portions of the valve seat, and an axially-extending second mid-portion angularly extending between the opposing first marginal portions and superimposed onto the first mid-portion of the valve seat. The flexible valve cover and valve seat form a normally closed axially and angularly extending valve seam therebetween.

Abstract translation: 装置包括具有共模塑的第一支撑件，阀盖和弹性致动器的第一部件，以及具有注射成型的第二支撑件，阀座和可变容积的储存室预成型件的第二部件。 预成型件被吹塑成定义可变容积储存室的柔性袋。 单向阀包括限定轴向延伸的相对的第一边缘部分的半环形曲线的相对刚性的阀座，以及在相对的第一边缘部分之间成角度地延伸的轴向延伸的第一中间部分。 柔性阀构件叠加在阀座上并且限定轴向延伸的相对的第二边缘部分，其固定地固定在阀座的相应的第一边缘部分上或邻近阀座的相应的第一边缘部分，以及轴向延伸的第二中间部分，其在相对的第一 边缘部分并重叠在阀座的第一中间部分上。 柔性阀盖和阀座在其间形成常闭轴向和角度延伸的阀接缝。

公开(公告)号：US08966866B2

公开(公告)日：2015-03-03

申请号：US13861502

申请日：2013-04-12

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/04 ,  B67B1/03 ,  B65B51/02 ,  B65B55/08 ,  B65B3/00 ,  B65B61/00 ,  B65B7/16

CPC classification number: B65B3/003 ,  B65B7/16 ,  B65B51/02 ,  B65B55/04 ,  B65B55/08 ,  B65B55/10 ,  B65B61/002 ,  B65B2039/009

Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

Abstract translation: 用于无菌填充的装置和方法包括使包括针穿透隔膜的装置的针穿透表面和与针可穿透隔膜流体连通的密封室中的污染。 填充针穿透针穿透隔膜，通过填充针引入物质并进入腔室，然后从隔膜中取出。 将液体密封剂施加到隔膜的穿透区域。 将辐射或能量施加到液体密封剂以将液体密封剂从液相固化至固相。

公开(公告)号：US08739838B2

公开(公告)日：2014-06-03

申请号：US13352235

申请日：2012-01-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: B65B1/04 ,  G01N23/00 ,  B65B51/10 ,  A61M5/178 ,  B29C65/00 ,  A61L2/10

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one filling or needle assembly and is adjustable to receive a plurality of filling or needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of containers or vials that are to be filled concurrently and adjusting an assembly to include at least one filling or needle assembly and at least one seal assembly. A number of the filling or needle assemblies and the seal assemblies equals the number of containers or vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个填充物或针头组件，并且可调节以容纳多个填充物或针头组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的多个容器或小瓶，并且调整组件以包括至少一个填充物或针组件和至少一个密封组件。 许多填充物或针组件和密封组件等于容器或小瓶的数量。

公开(公告)号：US08672195B2

公开(公告)日：2014-03-18

申请号：US11938103

申请日：2007-11-09

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D5/72

CPC classification number: B65D47/205 ,  A45D40/26 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D83/0055

Abstract: A container including a nozzle and body depending therefrom. The body is preferably tubular and defines an interior which retains a product to be dispensed. A cap engages the nozzle to prevent inadvertent release of the product. In order to dispense the product, the cap is removed and pressure is applied to the body and the nozzle allows release of the product. The nozzle releases the product without exposing the remaining product to the external atmosphere, thus the sterility of the interior of the body is maintained and the shelf life of the product is increased. The nozzle includes an inner body, coupled to the tubular body, surrounded by a flexible outer cover. A seam between the inner body and flexible outer cover forms a one-way release valve wherein a portion of the seam remains closed during dispensing the product.

Abstract translation: 一种容器，其包括从其排出的喷嘴和主体。 主体优选地是管状的并且限定保持要分配的产品的内部。 盖子与喷嘴接合以防止产品的意外释放。 为了分配产品，盖被去除并且压力施加到主体上，并且喷嘴允许释放产品。 喷嘴释放产品而不将剩余的产品暴露于外部大气，从而维持身体内部的不整洁性并且提高了产品的保质期。 该喷嘴包括一个连接到管状主体的内部主体，被一个柔性的外盖包围。 内体和柔性外盖之间的接缝形成单向释放阀，其中在分配产品期间，接缝的一部分保持关闭。

公开(公告)号：US08646243B2

公开(公告)日：2014-02-11

申请号：US12245678

申请日：2008-10-03

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/00

CPC classification number: A23L3/04 ,  A23L2/46 ,  A23L3/22 ,  B65B3/04 ,  B65B55/025 ,  B65B55/10 ,  B65B55/12

Abstract: An apparatus and method are provided for formulating and aseptically filling liquid products. A first liquid source includes at least one first liquid component; a second liquid source includes at least one second liquid component; and a container includes a body defining an empty, sterile storage chamber therein that is sealed with respect to ambient atmosphere. The container is introduced into a sterile filling chamber. A first filling member coupled in fluid communication with the first liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the first liquid component is aseptically introduced through the first filling member and into the storage chamber. A second filling member coupled in fluid communication with the second liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the second liquid component is aseptically introduced through the second filling member and into the storage chamber and, in turn, the first and second liquid components are combined into a liquid product formulation within the sterile chamber of the container. The first and second filling members are withdrawn from fluid communication with the storage chamber of the container located within the sterile filling chamber, and the filled storage chamber is sealed with respect to ambient atmosphere to hermetically seal the liquid product formulation within the storage chamber of the container.

Abstract translation: 提供了用于配制和无菌灌装液体产品的装置和方法。 第一液体源包括至少一个第一液体组分; 第二液体源包括至少一个第二液体组分; 并且容器包括在其中限定相对于环境大气密封的空的无菌储存室的主体。 将容器引入无菌填充室。 与第一液体源流体连通的第一填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，第一液体组分被无菌地通过第一填充构件引入储存室 。 与第二液体源流体连通的第二填充构件被放置成与位于无菌填充室中的容器的储存室流体连通，并且第二液体组分被无菌地通过第二填充构件引入并进入储存室 而又将第一和第二液体组分组合成容器无菌室内的液体产品制剂。 第一和第二填充构件与位于无菌填充室内的容器的储存室流体连通地取出，并且填充的储存室相对于环境大气密封，以将液体产品配制物气密地密封在储存室内 容器。