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    Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
    141.
    发明授权
    Methods for a particle precipitation and coating using near-critical and supercritical antisolvents 失效
    使用近临界和超临界反溶剂进行颗粒沉淀和涂层的方法

    公开(公告)号：US5833891A

    公开(公告)日：1998-11-10

    申请号：US805215

    申请日：1997-02-27

    申请人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    发明人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    IPC分类号： A61K9/16 ,  A61K9/50 ,  B01J2/04 ,  B05D1/02 ,  B01D11/00

    CPC分类号： A61K9/1676 ,  A61K9/1688 ,  B01J2/04 ,  B05D1/025 ,  A61K9/1694 ,  A61K9/5089 ,  B05D2401/90

    摘要： Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets; the enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 .mu.m. In coating processes, a turbulent fluidized flow of core particles is created using an SCF antisolvent in an enclosed zone. The core particles are contacted therein at near- or supercritical conditions by a fluid dispersion containing a dispersant together with a precipitatable substance. The antisolvent depletes the dispersant and the substance is precipitated onto the fluidized core particles. In another aspect of the invention, a process for preparing and administering a medicament using only a single container is provided. In such method, a fluid dispersion having a dispersant with the medicament therein is contacted with an antisolvent at near- or supercritical conditions within a use container, so as to directly precipitate small particles of the medicament in the container. The antisolvent is then removed and the use container is sealed with the medicament particles therein. Thereafter, dose(s) of the medicament can be withdrawn from the use container and administered to a patient.

    摘要翻译： 描述了使用近或超临界流体条件改进颗粒沉淀和涂层的方法和装置。 具有连续相分散剂和至少一种可沉淀物质的流体分散体与超临界流体（SCF）反溶剂接触，以产生聚焦的高频反溶剂声波，将分散体分解成极小的液滴; 液滴和抗溶剂之间的增强的传质速率导致非常小的颗粒的沉淀约0.1-10μm。 在涂覆过程中，使用封闭区域中的SCF反溶剂产生核心颗粒的湍流流化流。 核心颗粒在近或超临界条件下通过含有分散剂和可沉淀物质的流体分散体接触。 反溶剂消耗分散剂，物质沉淀在流化核心颗粒上。 在本发明的另一方面，提供了仅使用单一容器制备和施用药物的方法。 在这种方法中，将具有药物的分散剂的流体分散体与使用容器内的近临界或超临界条件下的反溶剂接触，从而将药物的小颗粒直接沉淀在容器中。 然后将抗溶剂除去，并将使用容器用其中的药物颗粒密封。 此后，药物的剂量可以从使用容器中取出并给予患者。

    Use of silica gel for DNA extraction with organic solvents
    143.
    发明授权
    Use of silica gel for DNA extraction with organic solvents 失效
    使用硅胶进行DNA萃取有机溶剂

    公开(公告)号：US5175271A

    公开(公告)日：1992-12-29

    申请号：US825695

    申请日：1992-01-27

    申请人： Stanley Thomas ,  Lowell Tilzer ,  Ruben Moreno

    发明人： Stanley Thomas ,  Lowell Tilzer ,  Ruben Moreno

    IPC分类号： C12N15/10 ,  C12Q1/68

    CPC分类号： C12N15/1003 ,  C12N15/1006 ,  C12Q1/6806 ,  Y10S435/803

    摘要： The invention describes a method for extracting DNA from a sample. It involves contacting a sample with a separation reagent which permits differentiated solvation of DNA and protein. By adding a gel polymer, such as a silical gel polymer to the mixture of sample and separating reagent followed by agitation via, e.g., centrifugation, the DNA and protein are separated, with the gel acting as a block to prevent contamination of the DNA phase by the protein. Higher yields of DNA are obtained as compared to methodologies where the gel is not used. Additionally, the problems associated with the physical contact of the solvents, which are frequently carcinogens, are avoided. Also taught are kits which can be used in connection with the inventive method.

    摘要翻译： 本发明描述了从样品中提取DNA的方法。 它包括使样品与分离试剂接触，分离试剂允许DNA和蛋白质的分化溶剂化。 通过向样品和分离试剂的混合物中加入诸如硅胶凝胶聚合物的凝胶聚合物，然后通过例如离心进行搅拌，分离DNA和蛋白质，凝胶充当块，以防止DNA相的污染 由蛋白质。 与不使用凝胶的方法相比，获得更高的DNA产量。 此外，避免了与经常致癌的溶剂的物理接触相关的问题。 还教导了可以结合本发明的方法使用的试剂盒。

    Use of gel polymer for DNA extraction with organic solvents
    144.
    发明授权
    Use of gel polymer for DNA extraction with organic solvents 失效
    使用凝胶聚合物进行DNA萃取与有机溶剂

    公开(公告)号：US5106966A

    公开(公告)日：1992-04-21

    申请号：US381588

    申请日：1989-07-10

    申请人： Stanley Thomas ,  Lowell Tilzer ,  Ruben Moreno

    发明人： Stanley Thomas ,  Lowell Tilzer ,  Ruben Moreno

    IPC分类号： C12N15/10 ,  C12Q1/68

    CPC分类号： C12N15/1003 ,  C12Q1/6806 ,  Y10S435/803

    摘要： The invention describes a method for extracting DNA from a sample. It involves contacting a sample with a separation reagent which permits differentiated solvation of DNA and protein. By adding a gel polymer, such as a polyester gel polymer to the mixture of sample and separating reagent followed by agitation via, e.g., centrifugation, the DNA and protein are separated, with the gel acting as a block to prevent contamination of the DNA phase by the protein. Higher yields of DNA are obtained as compared to methodologies where the gel is not used. Additionally, the problems associated with the physical contact of the solvents, which are frequently carcinogens, are avoided. Also taught are kits which can be used in connection with the inventive method.

    摘要翻译： 本发明描述了从样品中提取DNA的方法。 它包括使样品与分离试剂接触，分离试剂允许DNA和蛋白质的分化溶剂化。 通过将诸如聚酯凝胶聚合物的凝胶聚合物添加到样品和分离试剂的混合物中，然后通过例如离心进行搅拌，分离DNA和蛋白质，凝胶充当块，以防止DNA相的污染 由蛋白质。 与不使用凝胶的方法相比，获得更高的DNA产量。 此外，避免了与经常致癌的溶剂的物理接触相关的问题。 还教导了可以结合本发明的方法使用的试剂盒。

    Shortening sparing process for chemically leavened baked and fried products and compositions for preparing the same
    146.
    发明授权
    Shortening sparing process for chemically leavened baked and fried products and compositions for preparing the same 失效
    化学发酵烘烤和油炸产品及其制备用组合物的保存过程缩短

    公开(公告)号：US3919434A

    公开(公告)日：1975-11-11

    申请号：US41423473

    申请日：1973-11-09

    申请人： KANSAS UNIVERSITY RESEARCH FOU

    发明人： TSEN CHO C ,  HOOVER WILLIAM J

    IPC分类号： A21D2/16 ,  A21D10/04 ,  A21D2/26 ,  A21D10/00

    CPC分类号： A21D2/16

    摘要： A method of substantially decreasing the shortening content normally required in chemically leavened wheat flour based doughs or batters which comprises incorporating into the dough or batter in lieu of the shortening omitted, from about 0.1 to 3% by weight, based upon the flour content therein, of an additive selected from the group consisting of the sodium and calcium salts of acyl lactylates of C14-C22 fatty acids. The preferred additives are sodium stearoyl lactylate and calcium stearoyl lactylate, each being utilized at a concentration of about 0.5% by weight. In optional procedures, a protein supplement such as soy flour can be added to the dough or batter products without noticeably affecting the appearance and taste characteristics of the finished product.

    摘要翻译： 一种基本上减少化学发酵的小麦粉面团或面糊中通常需要的起酥油含量的方法，其包括将基于其中的面粉含量从约0.1至3重量％中加入面团或面糊而不是起酥油中， 的选自C14-C22脂肪酸的酰基乳酸盐的钠盐和钙盐的添加剂。 优选的添加剂是硬脂酰乳酸钠和硬脂酰乳酸钙，各自以约0.5重量％的浓度使用。 在任选的方法中，蛋白质补充剂如大豆粉可以添加到面团或面糊产品中，而不会显着影响成品的外观和味道特征。

    Ketamine treatment for amyotrophic lateral sclerosis
    148.
    发明授权
    Ketamine treatment for amyotrophic lateral sclerosis 有权

    公开(公告)号：US12128012B2

    公开(公告)日：2024-10-29

    申请号：US17770543

    申请日：2021-05-14

    申请人： University of Kansas

    发明人： Richard Barohn ,  John A. Stanford ,  Matthew Macaluso

    IPC分类号： A61K31/135 ,  A61P25/28

    CPC分类号： A61K31/135 ,  A61P25/28

    摘要： A method of treating amyotrophic lateral sclerosis (ALS) is provided to extend life expectancy in a subject. The method can include administering the ketamine to a subject having ALS such that the subject has an extended life expectancy compared to life expectancy of the subject prior to being administered the ketamine. The extended life expectancy is determined by the subject having a first progression rate of ALS prior to being administered ketamine and a second progression rate of ALS after being administered ketamine. The first progression rate is faster than the second progression rate such that the progression of ALS in the subject is slowed by the ketamine.

    AERIAL VEHICLES AND METHODS OF USE
    149.
    发明公开
    AERIAL VEHICLES AND METHODS OF USE 审中-公开

    公开(公告)号：US20240327045A1

    公开(公告)日：2024-10-03

    申请号：US18681408

    申请日：2022-08-05

    申请人： University of Kansas

    发明人： Ronald M. BARRETT ,  Mason Ross DENNELER ,  Zachary SCHWAB

    IPC分类号： B64U30/299 ,  B64U20/30 ,  B64U60/50

    CPC分类号： B64U30/299 ,  B64U20/30 ,  B64U60/50

    摘要： This disclosure generally relates to aerial vehicles that may convert from hover-mode to missile-mode flight and back via body tilt for efficient flight and can strike wires such that neither the wires nor the aircraft are damaged, and divergence is prevented. This includes an aerial vehicle having an elongate fuselage having a nose tip, a plurality of engines connected to the fuselage, and at least three protective members connected substantially near the nose tip of the fuselage longitudinally beyond the plurality of engines.