公开(公告)号：US10786530B2

公开(公告)日：2020-09-29

申请号：US15954776

申请日：2018-04-17

Applicant: International Business Machines Corporation ,  Agency For Science, Technology and Research

Inventor： Daniel J. Coady ,  Richard A. Dipietro ,  Amanda C. Engler ,  James L. Hedrick ,  Ashlynn L. Z. Lee ,  Victor W. L. Ng ,  Zhan-Yuin Ong ,  Yi Yan Yang

IPC: A61K31/785 ,  A61K31/80 ,  C08G64/02 ,  A01N25/10 ,  A01N33/12

Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

公开(公告)号：US20200299477A1

公开(公告)日：2020-09-24

申请号：US16892269

申请日：2020-06-03

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Xu LI ,  Yu Yuan Chieng ,  Siew Yee Wong ,  Xikui Zhang

IPC: C08J7/04 ,  C08F20/06 ,  C08F2/44 ,  C09D4/06 ,  C09D133/02

Abstract: This invention relates to a one-step process for making a polymer composite suspension for coating plastic films characterized in that a first polymer is synthesized in-situ optionally in the presence of other polymers and in the presence of clay. Preferably the polymer composite suspension comprises a) 1.0 to 11.0 wt % of clay or silane modified clay, b) 0.1 to 10.0) wt % of poly (acrylic acid), which is a copolymer of acrylic acid (AA) with at least one other monomer selected from 2-ethylhexyl acrylate (EHA), β-carboxyethyl acrylate (β-CEA), methacrylamidoethyl ethylene urea (WAM II) and ethoxylated behenyl methacrylate (β-FM), c) 1.0 to 15.0 wt % of other polymers, preferably poly (vinyl alcohol) and d) 70 to 97 wt % of water or mixture of water with 2-propanol. The coating films made from the suspensions show good barrier capabilities against water vapor and oxygen can be used to make barrier layers on or within plastic films for packaging applications. The invention also relates to methods for making silane modified clay usable in the process for making the suspensions.

公开(公告)号：US20200292538A1

公开(公告)日：2020-09-17

申请号：US16086285

申请日：2017-03-23

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Jayakumar Perumal ,  Ghayathri Balasundaram

IPC: G01N33/543 ,  G01N21/65 ,  B01L3/00 ,  G01N33/574

Abstract: A biosensor for the detection of an analyte using surface-enhanced Raman spectroscopy (SERS) is provided. The biosensor includes a SERS-active substrate and a microfludic circuit device arranged to be in fluid communication with the SERS-active substrate. Method of manufacturing a biosensor, and methods for detecting an analyte using the biosensor, wherein the analyte may be haptoglobin, are also provided.

公开(公告)号：US10767182B2

公开(公告)日：2020-09-08

申请号：US15526716

申请日：2015-11-16

Applicant: VIB VZW ,  Katholieke Universiteit Leuven, K.U.Leuven R&D ,  Agency for Science, Technology and Research (A*Star)

Inventor： Jean-Christophe Marine ,  Ernesto Guccione ,  Marco Bezzi

IPC: C12N15/113 ,  A61K31/7088 ,  C12Q1/6886 ,  A61K45/06 ,  A61K31/506 ,  A61K31/437 ,  A61K31/428 ,  A61K31/713

Abstract: The present application relates to the field of cancer, particularly that of cancers with high MDM4 protein levels (such as melanoma, breast, colon or lung cancers, glioblastoma, retinoblastoma, etc.). It is shown herein that direct and selective inhibition of MDM4, e.g., by antisense RNA, leads to growth inhibition of cancer cells and sensitization to chemo or targeted therapies. Also provided are simple ways of determining which patients are most amenable for such treatment by comparing specific transcript levels.

公开(公告)号：US10745586B2

公开(公告)日：2020-08-18

申请号：US15671639

申请日：2017-08-08

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： Amos Cahan ,  Xin Ding ,  Mareva B. Fevre ,  James L. Hedrick ,  Zhen Chang Liang ,  Nathaniel H. Park ,  Theodore G. van Kessel ,  Rudy J. Wojtecki ,  Yi Yan Yang

IPC: C09D181/04 ,  A61L31/10 ,  A61L31/16 ,  C09D5/14 ,  A01N33/08 ,  B05D1/02 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  C09D5/16 ,  A61L27/34 ,  B05D5/08

Abstract: According to one or more embodiments, a method of making an antifouling coating includes forming a polythioaminal polymer by reacting a fluorinated primary amine with an aldehyde to form an intermediate imine, and then reacting the intermediate imine with a dithiol. The method further includes depositing the polythioaminal on a substrate, and increasing a temperature of the polythioaminal deposited on the substrate to crosslink the polythioaminal and increase a contact angle of the substrate with crosslinked polythioaminal.

公开(公告)号：US10743537B2

公开(公告)日：2020-08-18

申请号：US15839199

申请日：2017-12-12

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： Mareva B. Fevre ,  James L. Hedrick ,  Nathaniel H. Park ,  Victoria A. Piunova ,  Pang Kern Jeremy Tan ,  Yi Yan Yang ,  Mu San Zhang

IPC: A01N37/30 ,  A01N43/50 ,  C07C231/12 ,  C07C233/78 ,  C07D233/61 ,  A01N33/12

Abstract: Techniques regarding ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments can comprise a monomer, which can comprise a single ionene unit. The single ionene unit can comprise a cation distributed along a molecular backbone. Also, a hydrophobic functional group can be covalently bonded to the molecular backbone, and the single ionene unit can have antimicrobial functionality.

公开(公告)号：US10739342B2

公开(公告)日：2020-08-11

申请号：US15507206

申请日：2015-08-28

Applicant: Agency For Science, Technology and Research

Inventor： Jackie Y. Ying ,  Yi Zhang ,  Jianhao Bai

IPC: G01N33/558 ,  G01N33/543 ,  G01N33/52

Abstract: There is provided a test strip assembly for detecting the possible presence of at least one analyte in a sample, a device for detecting the possible presence of at least one analyte in a sample comprising the test strip assembly and methods of detecting the possible presence of at least one analyte in a sample using the device.

公开(公告)号：US20200236913A1

公开(公告)日：2020-07-30

申请号：US16650814

申请日：2018-09-25

Applicant: National University of Singapore ,  Agency for Science, Technology and Research

Inventor： Linfa WANG ,  Qingfeng CHEN ,  Han Jia Justin NG ,  Kylie Su Mei YONG

IPC: A01K67/027

Abstract: Generation of chimeric non-human animals hosting bat donor cells involves chimeric mice having bat cells that may be stably tolerated to provide a new platform technology in the general field of biology, and having application in the field of immunology related to virus-host interaction, cancer biology, autoimmunity, and the development of new drugs.

公开(公告)号：US10711019B2

公开(公告)日：2020-07-14

申请号：US15752866

申请日：2016-08-17

Applicant: Agency for Science, Technology and Research

Inventor： Fuke Wang ,  Fei Wang ,  Chaobin He

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C07F7/21 ,  C08F2/48 ,  C08G77/38 ,  C08L83/08 ,  C08G77/24

Abstract: This invention relates to a photoinitiator compound comprising: a polyhedral oligomeric silsesquioxane (POSS) moiety and a photoinitiator moiety, wherein the photoinitiator compound having the structure according to formula (I): [R—SiO1.5]n (I), wherein n is 6, 8, 10 or 12 and R is independently selected from the group consisting of H, linear or branched (hetero)alkyl, linear or branched (hetero)alkenyl, (hetero)aryl, (hetero)alkyl aryl, (hetero)aryl alkyl and a photoinitiator moiety, wherein at least one R is a photoinitiator moiety and the photoinitiator compound is a nanoparticle. The present invention also relates to a method for the production of the photoinitiator compound of the invention, a photopolymerizable composition comprising the photoinitiator compound of the invention, the use of the photoinitiator compound of the invention for photopolymerization. The present invention is further related to a coated substrate comprising the photopolymerizable composition of the invention.

公开(公告)号：US10710005B2

公开(公告)日：2020-07-14

申请号：US15660626

申请日：2017-07-26

Applicant: Agency for Science, Technology and Research

Inventor： Yi Ren ,  Sing Yang Chiam ,  Lai Mun Wong

IPC: B01D15/08 ,  B01J20/32 ,  B01J20/28 ,  B01J20/02 ,  C02F1/28 ,  B01J20/00 ,  C02F101/30

Abstract: An adsorbent material is provided. The adsorbent material comprises a porous, non-particulate substrate comprising pores having a size in the range of about 1 μm to about 1 mm, and a conformal coating film deposited on the porous, non-particulate substrate, wherein the conformal coating film comprises topographical features having a feature size in the range of about 1 nm to about 1 μm. A method of preparing the adsorbent material and an adsorbent device are also provided.