公开(公告)号：US20210277361A1

公开(公告)日：2021-09-09

申请号：US17271902

申请日：2019-08-26

Applicant: MICAN TECHNOLOGIES INC. ,  KUMAMOTO UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Kazuo MIYAZAKI ,  Atsushi YAMANAKA ,  Minoru OKADA ,  Satoru SENJYU

IPC: C12N5/10 ,  G01N33/50 ,  A61K39/12

Abstract: The present invention has been made in view of a problem regarding stability, reproducibility, economy, and easiness of operation in studies for a monocyte- or dendritic cell-mediated infectious microorganism, and is directed to provide a method for maintenance culturing a monocyte- or dendritic cell-mediated infectious microorganism utilizing a monocyte having a proliferative capacity. The present invention is based on the finding that a dengue virus efficiently infects a proliferable human monocytic cell obtained by introducing a gene into a CD14-positive cell and a cell having a phagocytic capacity obtained by inducing the monocytic cell to differentiate (e.g., dendritic cell) and proliferates therein. Thus, provided is a novel method for evaluating a pharmaceutical such as a compound or a vaccine for treating an infection with a monocyte- or dendritic cell-mediated infectious microorganism.

公开(公告)号：US20210273057A1

公开(公告)日：2021-09-02

申请号：US17141273

申请日：2021-01-05

Applicant: KABUSHIKI KAISHA TOSHIBA ,  OSAKA UNIVERSITY

Inventor： Toshiki HIKOSAKA ,  Shinya NUNOUE ,  Tomoyuki TANIKAWA ,  Ryuji KATAYAMA ,  Masahiro UEMUKAI

IPC: H01L29/20 ,  H01L21/02 ,  G02F1/355 ,  G02F1/37 ,  C23C16/30

Abstract: According to one embodiment, a nitride crystal includes first, second, and third nitride crystal regions. The third nitride crystal region includes Al, and is provided between the first and second nitride crystal regions. A third oxygen concentration in the third nitride crystal region is greater than a first oxygen concentration in the first nitride crystal region and greater than a second oxygen concentration in the second nitride crystal region. A third carbon concentration in the third nitride crystal region is greater than a first carbon concentration in the first nitride crystal region and greater than a second carbon concentration in the second nitride crystal region. A direction of the first nitride crystal region is one of a first orientation from the second nitride crystal region toward the first nitride crystal region or a second orientation from the first nitride crystal region toward the second nitride crystal region.

公开(公告)号：US20210263339A1

公开(公告)日：2021-08-26

申请号：US17254120

申请日：2019-06-20

Applicant: OSAKA UNIVERSITY

Inventor： Kohji NISHIDA ,  Koichi BABA ,  Shizuka KOH ,  Kei OHKUBO ,  Haruyasu ASAHARA ,  Tsuyoshi INOUE ,  Hiroshi UYAMA ,  Taka-Aki ASOH

IPC: G02C7/04 ,  A61F2/16 ,  B29D11/00

Abstract: The present invention provides a new method for producing a lens to be fitted to an eye in a simple manner at a low cost. In order to achieve the aforementioned object, the present invention provides a method for producing a lens to be fitted to an eye, including the step of: hydrophilizing a surface of a polymer lens by reacting with a compound radical, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

公开(公告)号：US11098275B2

公开(公告)日：2021-08-24

申请号：US15771180

申请日：2016-10-28

Applicant: THE UNIVERSITY OF TOKYO ,  OSAKA UNIVERSITY

Inventor： Sadao Ota ,  Issei Sato ,  Katsuhito Fujiu ,  Satoko Yamaguchi ,  Kayo Waki ,  Yoko Itahashi ,  Ryoichi Horisaki

IPC: G01N21/49 ,  C12M1/34 ,  G01N15/14 ,  G01N21/01 ,  G01N21/27 ,  G01N21/64 ,  G06K9/62 ,  G06K9/00 ,  G01N21/65 ,  G01N15/10

Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.

公开(公告)号：US11097374B2

公开(公告)日：2021-08-24

申请号：US16324108

申请日：2017-08-04

Applicant: OSAKA UNIVERSITY ,  TOSHIBA MATERIALS CO., LTD.

Inventor： Hidetoshi Fujii ,  Yoshiaki Morisada ,  Kai Funaki ,  Isao Ikeda ,  Yutaka Abe ,  Masahiro Kato

IPC: B23K20/12 ,  C04B35/584 ,  C04B35/587 ,  C04B35/626 ,  C04B35/63 ,  C04B35/645 ,  B23K103/04

Abstract: The friction stir welding tool member according to the present invention is made of a silicon nitride sintered body, wherein the silicon nitride sintered body contains 15% by mass or less of additive components except silicon nitride in such a manner that the additive components include at least one element selected from lanthanoid elements and at least one element selected from Mg, Ti, Hf, and Mo. In addition, it is preferable that the additive components further include at least one element selected from Al, Si, and C. According to the above-described configuration, a friction stir welding tool member having an excellent durability can be provided.

公开(公告)号：US11085916B2

公开(公告)日：2021-08-10

申请号：US16085755

申请日：2017-07-18

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kie Nakashima ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Kiyotoshi Sekiguchi ,  Atsushi Tanemura ,  Hiroyuki Murota ,  Ichiro Katayama

IPC: G01N33/50 ,  A61B5/00 ,  A61K38/18

Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.

公开(公告)号：US20210238171A1

公开(公告)日：2021-08-05

申请号：US17050070

申请日：2019-04-26

Applicant: OSAKA UNIVERSITY ,  KYOTO UNIVERSITY ,  Inter-University Research Institute Corporation National Institutes of Natural Sciences

Inventor： Ryu NAGATA ,  Yasuo MORI ,  Masayuki MORI ,  Motohiro NISHIDA ,  Takuro TOMITA

IPC: C07D413/12 ,  C07D413/14 ,  C07D261/20 ,  C07D417/12 ,  C07D487/08 ,  C07D413/04 ,  A61P43/00

Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).

公开(公告)号：US11065084B2

公开(公告)日：2021-07-20

申请号：US15770461

申请日：2016-10-21

Applicant: OSAKA UNIVERSITY

Inventor： Chihiro Tanikawa ,  Kenji Takada

IPC: A61C7/00 ,  G16H30/40 ,  A61B34/10 ,  G16H50/50 ,  G06T13/40

Abstract: To have convenient and highly precise prediction of the shape of a human body after a treatment by calculation processing that includes extracting a feature vector Fnew from face data of a patient as an evaluation subject, selecting a plurality of case patients having feature vectors Fpre(i), extracted from the face data of a plurality of previous patients, obtaining pre-orthodontic facial shape models Hpre(i) and a post-orthodontic facial shape models Hpost(i) in which the faces of the selected previous case patients before and after a treatment have been normalized, obtaining a facial shape model Hnew, and obtaining a three-dimensional predicted facial shape model Hprd, by modifying the facial shape model Hnew of the patient as an evaluation subject, using a vector average difference AVEpost−AVEpre between the pre-treatment and post-treatment facial shape models.

公开(公告)号：US20210216016A1

公开(公告)日：2021-07-15

申请号：US17251722

申请日：2019-06-14

Applicant: OSAKA UNIVERSITY

Inventor： Seiichi TAGAWA

IPC: G03F7/38

Abstract: A resist pattern formation method includes: forming on a substrate a resist layer containing a base resin, a sensitizer precursor, an acid generator, a base generator, and a base; generating a sensitizer from the sensitizer precursor; generating an acid from the acid generator and a base from the base generator; performing heat treatment on the resist layer after flood exposure; and developing the resist layer after the heat treatment. A ratio (C1=A1/B1) of a value (A1) representing an acid in pattern exposure to a value (B1) representing a base in the pattern exposure satisfies a relationship 0.9×C1

公开(公告)号：US11053313B2

公开(公告)日：2021-07-06

申请号：US16611678

申请日：2018-04-26

Applicant: OSAKA UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY ,  FUJIFILM Wako Pure Chemical Corporation

Inventor： Masuo Kondoh ,  Kiyohito Yagi ,  Takefumi Doi ,  Yoshiaki Okada ,  Yosuke Hashimoto ,  Tatsuya Sawasaki ,  Hiroyuki Takeda ,  Kohki Endo ,  Maki Tamura

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28

Abstract: An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.