公开(公告)号：US09453793B2

公开(公告)日：2016-09-27

申请号：US13452218

申请日：2012-04-20

Applicant: Alexandre M Bratkovski ,  R Stanley Williams ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  R Stanley Williams ,  Zhiyong Li

IPC: G01N21/00 ,  G01N21/01 ,  G01N21/65 ,  G01N21/64

CPC classification number: G01N21/01 ,  G01N21/648 ,  G01N21/658

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a flexible substrate, and an array of spaced apart sensing members formed on a surface of the flexible substrate. Each of the spaced apart sensing members includes a plurality of polygon assemblies. The polygon assemblies are arranged in a controlled pattern on the surface of the flexible substrate such that each of the plurality of polygon assemblies is a predetermined distance from each other of the plurality of polygon assemblies, and each of the plurality of polygon assemblies including collapsible signal amplifying structures controllably positioned in a predetermined geometric shape.

Abstract translation: 本文公开了集成传感器的示例。 集成传感器的示例包括柔性基板和形成在柔性基板的表面上的间隔开的感测部件阵列。 每个间隔开的感测构件包括多个多边形组件。 多边形组件以可控的图案布置在柔性基板的表面上，使得多个多边形组件中的每一个距离多个多边形组件中的彼此之间是预定距离，并且多个多边形组件中的每一个包括可折叠信号 放大结构可控地定位在预定的几何形状。

公开(公告)号：US09279767B2

公开(公告)日：2016-03-08

申请号：US13879255

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/00 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/6428 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54373

Abstract: A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing. The chemical-analysis device includes a metallic-nanofinger device, and a platform. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A method for using, and a chemical-analysis apparatus including the chemical-analysis device are also provided.

Abstract translation: 与用于化学感测的金属纳米酮装置集成的化学分析装置。 化学分析装置包括金属纳米装置和平台。 金属纳米装置包括衬底和与衬底耦合的多个纳米器件。 多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。 至少纳米角蛋白和多个纳米针的第二纳米角键将与至少一个分析物分子自组织成紧密堆积的构型。 金属盖的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了一种使用方法和包括该化学分析装置的化学分析装置。

公开(公告)号：US09274058B2

公开(公告)日：2016-03-01

申请号：US13879245

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

Abstract translation: 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。

公开(公告)号：US09244015B2

公开(公告)日：2016-01-26

申请号：US13636784

申请日：2010-04-20

Applicant: Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu

IPC: G01J3/44 ,  B05D5/06 ,  B44C1/22 ,  C23C16/48 ,  C25D5/02 ,  G02B5/08 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1 C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.

Abstract translation: 用于表面增强发光的自配置发光增强装置101。 用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。 多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。 至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和 各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。

公开(公告)号：US20150177151A1

公开(公告)日：2015-06-25

申请号：US13194556

申请日：2011-07-29

Applicant: Min HU ,  Zhiyong LI ,  Fung Suong OU ,  Ansoon KIM

Inventor： Min HU ,  Zhiyong LI ,  Fung Suong OU ,  Ansoon KIM

IPC: G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01N21/658 ,  B82Y20/00 ,  G01J3/0256 ,  G01J3/4412 ,  G01N2201/06113 ,  Y10S977/954 ,  Y10T29/49

Abstract: In a method of fabricating an apparatus for use in a sensing application, a plurality of nano-fingers are formed on a substrate and a Raman-active material nano-particle is formed on respective tips of the nano-fingers. In addition, the Raman-active material nano-particles on the tips of adjacent ones of the nano-fingers are caused to come into contact with the Raman-active material nano-particle on the tip of at least another one of the plurality of nano-fingers to form respective clusters and the clusters of Raman-active material nano-particles are transferred to a component layer from the plurality of nano-fingers while maintaining a spatial relationship between the contacting Raman-active material nano-particles.

Abstract translation: 在制造用于感测应用的装置的方法中，在衬底上形成多个纳米指，并且在纳米手指的各个尖端上形成拉曼活性材料纳米颗粒。 另外，使相邻的纳米指尖的拉曼活性物质纳米粒子与多个纳米尺寸中的至少另一个的前端的拉曼活性物质纳米粒子接触 - 形成相应的簇，并且拉曼活性材料纳米颗粒簇从多个纳米指转移到组分层，同时保持接触拉曼活性材料纳米颗粒之间的空间关系。

公开(公告)号：US20150173656A1

公开(公告)日：2015-06-25

申请号：US14406601

申请日：2012-07-29

Applicant: Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

Inventor： Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

IPC: A61B5/1459 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/6862 ,  G01N21/658

Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.

Abstract translation: 可植入纳米传感器包括待植入流体导管内的支架。 支架在支架表面有一个井。 可植入纳米传感器还包括设置在井中的纳米级图案感测基片。 纳米级图案化感测衬底将产生光学散射响应信号，该信号指示由光学刺激信号询问时由流体导管携带的流体中的分析物的存在。

公开(公告)号：US20150116706A1

公开(公告)日：2015-04-30

申请号：US14394287

申请日：2012-04-24

Applicant: Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

Inventor： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01N2201/06113 ,  Y10S977/954

Abstract: An apparatus for performing a sensing application includes a reservoir to contain a solution, a dispenser to dispense the solution from the reservoir, and a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, in which the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus also includes an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, in which light is to be emitted from the analyte in response to being illuminated. The apparatus further includes a detector to detect the light emitted from the analyte.

Abstract translation: 用于执行感测应用的装置包括容纳溶液的储存器，用于从储存器分配溶液的分配器以及具有多个纳米手指的基板，该多个纳米手指定位成接收分配的溶液，其中多个纳米手指 是柔性的，使得多个纳米手指可相对于彼此配置。 所述装置还包括照亮所接收的溶液的照明源，围绕所述多个纳米手指引入的分析物和所述多个纳米手指，其中光将响应于被照亮从分析物发射。 该装置还包括检测器，用于检测从分析物发射的光。

公开(公告)号：US09019495B2

公开(公告)日：2015-04-28

申请号：US13563362

申请日：2012-07-31

Applicant: Ansoon Kim ,  Zhiyong Li ,  Steven J. Barcelo ,  Zhang-Lin Zhou ,  Gary Gibson

Inventor： Ansoon Kim ,  Zhiyong Li ,  Steven J. Barcelo ,  Zhang-Lin Zhou ,  Gary Gibson

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/77

CPC classification number: G01N21/658 ,  G01N2021/775 ,  Y10T29/49826

Abstract: According to an example, an apparatus for performing spectroscopy includes a structure having an opening. The apparatus also includes a plurality of surface-enhanced Raman spectroscopy (SERS) elements positioned within the structure and a porous membrane covering the opening and the plurality of SERS elements. The porous membrane is to allow a predetermined analyte to reach the SERS elements while substantially preventing other analytes from reaching the SERS elements.

Abstract translation: 根据示例，用于执行光谱的装置包括具有开口的结构。 该装置还包括位于结构内的多个表面增强拉曼光谱（SERS）元件和覆盖该开口的多孔膜和多个SERS元件。 多孔膜是允许预定的分析物到达SERS元素，同时基本上防止其它分析物到达SERS元件。

公开(公告)号：US08842265B2

公开(公告)日：2014-09-23

申请号：US13090016

申请日：2011-04-19

Applicant: David A. Fattal ,  Raymond G. Beausoieil ,  Zhiyong Li

Inventor： David A. Fattal ,  Raymond G. Beausoieil ,  Zhiyong Li

IPC: G01J3/44 ,  B82Y20/00 ,  G02B5/18 ,  B29D11/00

CPC classification number: B82Y20/00 ,  B29D11/00346 ,  B29D11/0074 ,  G02B5/1809 ,  G02B5/1828

Abstract: A configurable grating based on collapsing nano-fingers includes a substrate; and a plurality of bendable nano-fingers supported on the substrate. The nano-fingers may be formed in a regular first array and the nano-fingers may be formed in a spacing that, upon closing at their tops, forms a second array to act as an optical grating or a diagnostic tool. A method of fabricating a configurable optical grating based on collapsing nano-fingers is also disclosed, as well as a method of determining an open or closed state for a plurality of nano-fingers.

Abstract translation: 基于塌陷纳米指的可配置光栅包括基底; 以及支撑在基板上的多个可弯曲的纳米手指。 纳米指可以形成为规则的第一阵列，并且纳米指可以以间隔形成，在其顶部关闭时，形成第二阵列以用作光栅或诊断工具。 还公开了一种基于塌陷纳米手指制造可配置光栅的方法，以及确定多个纳米手指的打开或关闭状态的方法。

公开(公告)号：US08773882B2

公开(公告)日：2014-07-08

申请号：US12761300

申请日：2010-04-15

Applicant: Zhiyong Li ,  Warren Robinett

Inventor： Zhiyong Li ,  Warren Robinett

IPC: G11C5/06 ,  G11C5/12 ,  B82Y10/00 ,  B82B1/00 ,  B82B3/00 ,  B82Y40/00

CPC classification number: G11C5/06 ,  B82B1/00 ,  B82B3/00 ,  B82Y10/00 ,  B82Y40/00 ,  G11C5/12 ,  G11C2213/81 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/0676 ,  H01L29/068 ,  H01L51/0595 ,  Y10S977/762 ,  Y10S977/94

Abstract: Certain embodiments of the present invention are directed to a method of programming nanowire-to-conductive element electrical connections. The method comprises: providing a substrate including a number of conductive elements overlaid with a first layer of nanowires, at least some of the conductive elements electrically coupled to more than one of the nanowires through individual switching junctions, each of the switching junctions configured in either a low-conductance state or a high-conductance state; and switching a portion of the switching junctions from the low-conductance state to the high-conductance state or the high-conductance state to the low-conductance state so that individual nanowires of the first layer of nanowires are electrically coupled to different conductive elements of the number of conductive elements using a different one of the switching junctions configured in the high-conductance state. Other embodiments of the present invention are directed to a nanowire structure including a mixed-scale interface.

Abstract translation: 本发明的某些实施例涉及一种编程纳米线至导电元件电连接的方法。 该方法包括：提供包括覆盖有第一纳米线层的多个导电元件的衬底，至少一些导电元件通过单独的开关结与多于一个的纳米线电耦合，每个开关结配置在 低电导状态或高电导状态; 以及将所述开关结的一部分从所述低电导状态切换到所述高电导状态或所述高电导状态至所述低电导状态，使得所述第一纳米线层的单个纳米线电耦合到不同的导电元件 使用在高电导状态下配置的不同的一个开关结的导电元件的数量。 本发明的其它实施方案涉及包括混合规模界面的纳米线结构。