公开(公告)号：US20070101007A1

公开(公告)日：2007-05-03

申请号：US11264806

申请日：2005-11-01

申请人： William Brown ,  Richard Muirhead ,  Francis Reddington

发明人： William Brown ,  Richard Muirhead ,  Francis Reddington

IPC分类号： G06F15/16

CPC分类号： H04L67/2819 ,  H04L67/28

摘要： Methods, systems, and computer program products are provided for workflow decision management. Embodiments include maintaining a device state history; identifying a device usage pattern in dependence upon the device state history; identifying a workflow scenario in dependence upon the device usage pattern; identifying a workflow in dependence upon the workflow scenario; executing the workflow including: sending, to an intermediate message validation service, a message to be forwarded to a device to administer at least one value of an attribute of the device; determining, by the intermediate message validation service, that the message is valid; and forwarding, by the intermediate message validation service, the valid message to the device.

摘要翻译： 提供方法，系统和计算机程序产品用于工作流决策管理。 实施例包括维护设备状态历史; 根据设备状态历史识别设备使用模式; 根据设备使用模式识别工作流场景; 根据工作流场景识别工作流; 执行所述工作流程包括：向中间消息验证服务发送要转发到设备的消息以管理所述设备的属性的至少一个值; 由所述中间消息验证服务确定所述消息有效; 并通过中间消息验证服务将有效消息转发到设备。

公开(公告)号：US20070086017A1

公开(公告)日：2007-04-19

申请号：US11539275

申请日：2006-10-06

申请人： Eric Buckland ,  John Marciante ,  Joseph Izatt ,  William Brown

发明人： Eric Buckland ,  John Marciante ,  Joseph Izatt ,  William Brown

IPC分类号： G01B9/02 ,  G01J3/45 ,  G01B11/02

CPC分类号： G01N21/45 ,  A61B3/102 ,  A61B3/1225 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/23 ,  G01N2021/1787

摘要： Optical imaging systems are provided including a light source and a depolarizer. The light source is provided in a source arm of the optical imaging system. A depolarizer is coupled to the light source in the source arm of the optical imaging system and is configured to substantially depolarize the light from the light source. Related methods and controllers are also provided.

摘要翻译： 提供了包括光源和消偏振器的光学成像系统。 光源设置在光学成像系统的源臂中。 去偏振器耦合到光学成像系统的源极臂中的光源，并且被配置为基本上使来自光源的光去极化。 还提供了相关方法和控制器。

公开(公告)号：US20070073993A1

公开(公告)日：2007-03-29

申请号：US11239597

申请日：2005-09-29

申请人： Kenneth Allen ,  William Brown ,  Richard Kirkman ,  Kenneth Vossen

发明人： Kenneth Allen ,  William Brown ,  Richard Kirkman ,  Kenneth Vossen

IPC分类号： G06F12/00

CPC分类号： G06F12/121 ,  G06F9/5016 ,  G06F12/08

摘要： Memory allocation in a multi-node computer, including evaluating memory affinity among nodes and allocating memory in dependence upon the evaluations. Evaluating memory affinity may include assigning to nodes weighted coefficients of memory affinity where each weighted coefficient represents a desirability of allocating memory of a node to a processor of a node, and allocating memory may include allocating memory in dependence upon the weighted coefficients of memory affinity.

摘要翻译： 多节点计算机中的内存分配，包括评估节点之间的内存亲和度，并根据评估分配内存。 评估存储器亲和性可以包括向节点分配加权的存储器亲和度系数，其中每个加权系数表示将节点的存储器分配给节点的处理器的可取性，并且分配存储器可以包括依赖于加权的存储器亲和度系数来分配存储器。

公开(公告)号：US20070066653A1

公开(公告)日：2007-03-22

申请号：US10557068

申请日：2004-05-13

申请人： William Brown ,  Andrew Griffin

发明人： William Brown ,  Andrew Griffin

IPC分类号： A61K31/445 ,  C07D211/26

CPC分类号： C07D211/70

摘要： Compounds of general formula: Formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

摘要翻译： 通式为其中R 1，R 2，R 3和R 4的通式（I）的化合物是 如本说明书中所定义，以及其盐，对映异构体和包含该化合物的药物组合物。 它们可用于治疗，特别是治疗疼痛。

公开(公告)号：US07186733B2

公开(公告)日：2007-03-06

申请号：US10477633

申请日：2002-05-16

申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

IPC分类号： A61K31/4468 ,  C07D211/58

CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety or functional gastrointestinal disorders.

摘要翻译： 通式I R 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任一种; 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑或功能性胃肠道疾病中的用途。

公开(公告)号：US20060282963A1

公开(公告)日：2006-12-21

申请号：US11513632

申请日：2006-08-31

申请人： William Brown ,  Thomas Christman ,  Georges Driesen ,  Thomas Fritsch ,  Michael Roberts ,  Armin Schwarz-Hartmann

发明人： William Brown ,  Thomas Christman ,  Georges Driesen ,  Thomas Fritsch ,  Michael Roberts ,  Armin Schwarz-Hartmann

IPC分类号： A46B7/08

CPC分类号： A61C17/222 ,  A46B9/025 ,  A46B2200/1066

摘要： A head for an electric toothbrush includes a support member having a plurality of holes extending completely therethrough. A plurality of tufts of bristles each extends through one of the holes. A first brushing end of each tuft projects from a first side of the support member. Each tuft is prevented from being withdrawn from its hole when a tensile force is applied to the first end of each tuft along a long axis of the tuft. A resilient cushion is positioned adjacent a second side of the support member such that a second end of each tuft can contact the cushion. When a compressive force is applied to the first end of each tuft along the long axis of each tuft, each tuft can move in its hole in a first direction into the cushion. When the compressive force is removed the cushion causes each tuft to move in its hole in a second direction substantially opposite the first direction.

公开(公告)号：US20060118362A1

公开(公告)日：2006-06-08

申请号：US10998827

申请日：2004-11-30

申请人： William Brown ,  Walter Murray

发明人： William Brown ,  Walter Murray

IPC分类号： F16N33/00

CPC分类号： B60H1/00585 ,  F25B45/00 ,  F25B2345/001 ,  F25B2345/003

摘要： An automated hose clearing after refrigerant charge method and appropriate apparatus is provided. The method includes, determining if a pressure differential between a high and low pressure hose exceeds a predetermined threshold and temporarily providing fluid communication between the interiors of the high and low-pressure hoses.

摘要翻译： 提供制冷剂充注方法后的自动软管清理和适当的装置。 该方法包括：确定高低压软管之间的压力差是否超过预定阈值，并临时提供高压和低压软管内部之间的流体连通。

公开(公告)号：US07045625B2

公开(公告)日：2006-05-16

申请号：US10468989

申请日：2002-03-05

申请人： William Brown ,  Niklas Plobeck

发明人： William Brown ,  Niklas Plobeck

IPC分类号： C07D401/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D413/00

CPC分类号： C07D405/12 ,  C07D215/12 ,  C07D409/12

摘要： An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral sulfinimine to give adducts in predominantly one diastereomer can subsequently be transferred into pure enantiomers of by cleavage of the chiral auxilliary which is followed by synthesis of the piperazine ring by alkylation procedures.

摘要翻译： 描述了二芳基甲基哌嗪的不对称合成。 合成路线使得能够制备各种具有不同N-烷基的对映异构纯胺。 本发明包括将有机金属化合物不对称地加成到手性亚磺酰亚胺中以在主要一种非对映异构体中产生加合物，随后可以通过手性辅助剂的切割转移成纯对映异构体，然后通过烷基化方法合成哌嗪环。

公开(公告)号：US07022715B2

公开(公告)日：2006-04-04

申请号：US10477851

申请日：2002-05-16

申请人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

发明人： William Brown ,  Christopher Walpole ,  Zhongyong Wei

IPC分类号： A61K31/445 ,  A61K31/451 ,  C07D211/08

CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

摘要： Compounds of general formula I: R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C?6? alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

摘要翻译： 通式I：R 1的化合物选自苯基，吡啶基，吡咯基，噻吩基，呋喃基，咪唑基，三唑基，噻唑基和吡啶N-氧化物中的任何一种; 其中每个R 1苯基环和R 1'杂芳环可以任选地和独立地被1,2或3个选自直链和支链C 1的取代基取代， -C≡6 烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴，和 碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

公开(公告)号：US20060059804A1

公开(公告)日：2006-03-23

申请号：US11207738

申请日：2005-08-22

申请人： William Brown

发明人： William Brown

IPC分类号： E04C5/08

CPC分类号： E04C5/168 ,  E04C5/0604 ,  E04C5/0645

摘要： Structural reinforcing members are supplied for use in resisting shear forces within larger construction projects using reinforced concrete, along sites where strengthening ribs or beams between formers are to be created. The members also force the channels apart and maintain the reinforcing therein before curing at predetermined dimensions and spacings. A variant provides reinforcing cages that can be put together on the site for maintaining multiple reinforcing rods. The cages of different beams can intermesh at rib cross-over points. Example cages are eight-bar cages where each bar is made of 1.25 inch diameter reinforcing steel. During assembly the bars are held in place by the members with the assistance of gravity so that relatively little linking together of the reinforcing parts is required.

摘要翻译： 在使用钢筋混凝土的大型建筑工程中，为了抵抗剪切力，提供结构加固件，沿着要形成加强筋或梁之间的部位。 这些构件还在通道以预定的尺寸和间隔固化之前强制通道分开并保持其中的增强。 一个变体提供了可以在现场放置在一起以保持多个加强杆的加强笼。 不同梁的笼子可以在肋交叉点处相互啮合。 示例的笼子是八巴笼，其中每个条由1.25英寸直径的钢筋制成。 在组装期间，通过重力的帮助，杆被部件保持就位，因此需要加强部件相对较少的连接在一起。