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公开(公告)号：US10706904B2
公开(公告)日：2020-07-07
申请号：US16234876
申请日：2018-12-28
Inventor： Kien Trinh Quang , Massimo Alioto , Sergio Ruocco
Abstract: A method of providing a reference voltage for reading of a resistive memory array, and a read circuit for reading of a resistive memory array. The method comprises the steps of generating a first reference voltage when a bitline of the resistive memory array is in a first resistance state, and generating a second reference voltage when the bitline is in a second resistance state; wherein the first reference voltage is different from the first reference voltage and the first resistance state is different from the second resistance state.
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公开(公告)号：US10684272B2
公开(公告)日：2020-06-16
申请号：US15745431
申请日：2016-07-15
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Ee Chee Ren , Hul Ling Ko
IPC: A61K48/00 , C07H21/02 , C07H21/04 , G01N33/50 , A61K38/17 , C07K14/00 , C07K14/02 , A61P1/16 , A61P31/20 , A61K31/713 , G01N33/576
Abstract: Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.
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公开(公告)号：US20200181612A1
公开(公告)日：2020-06-11
申请号：US16329970
申请日：2017-09-04
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Ernesto GUCCIONE , Keng Boon Dave WEE
IPC: C12N15/113 , A61K9/127 , A61P35/00
Abstract: The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample.
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公开(公告)号：US20200181283A1
公开(公告)日：2020-06-11
申请号：US16309439
申请日：2017-06-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Qi ZENG
Abstract: The present invention relates to humanised antibodies that bind PRL3.
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公开(公告)号：US20200179487A1
公开(公告)日：2020-06-11
申请号：US16318089
申请日：2017-06-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Bruno REVERSADE , Lena Wai Mun HO
Abstract: The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detecting the susceptibility of an individual to pre-eclampsia, wherein the method comprises detecting modulation, preferably down-regulation of expression, amount or activity of ELABELA.
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Patent Agency Ranking
公开(公告)号：US10679860B2
公开(公告)日：2020-06-09
申请号：US15551821
申请日：2016-03-09
Applicant: Agency for Science, Technology and Research
Inventor： Lakshmi Kanta Bera , Yee Chong Loke , Surani Bin Dolmanan , Sudhiranjan Tripathy , Wai Hoe Tham
IPC: H01L29/66 , H01L21/285 , H01L29/51 , H01L29/20 , H01L29/778 , H01L21/28 , H01L29/205 , H01L29/40 , H01L29/45 , H01L29/49
Abstract: A method for fabrication of high electron mobility transistor (HEMT) semiconductor devices is presented. The method includes providing a substrate, growing a HEMT layer structure on the substrate; and self-aligned common metal stack formation of source, drain and gate electrodes on the HEMT layer structure using a single lithographic mask.
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公开(公告)号：US20200158642A1
公开(公告)日：2020-05-21
申请号：US16491960
申请日：2018-03-27
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Laura Sutarlie , Sian Yang Ow , Shilin Chen , Xiaodi Su
IPC: G01N21/64 , G01N33/542 , G01N33/569 , G01N15/06 , G01N21/359
Abstract: This invention relates to a sensor that detects bacteria cells comprising (a) a primary negatively charged, nanoparticulate sensing material; (b) a secondary positively charged, fluorescent sensing material; (c) a housing; and (d) at least one illuminator; wherein said housing contains said primary negatively charged, nanoparticulate sensing material, said secondary positively charged fluorescent sensing material and a sample potentially comprising bacteria in aqueous medium, wherein said illuminator provides light of at least one pre-specified wavelength λi to excite at least said secondary positively charged, fluorescent material, wherein said secondary positively charged, fluorescent material electrostatically attached to bacteria cells provides at least one fluorescent response at a second different wavelength λn wherein both i and n are integers, wherein said negatively charged, nanoparticulate sensing material electrostatically attached to said fluorescent material suppresses fluorescing of said fluorescent material at said second wavelength λn; and wherein said housing permits illumination of the contents of said housing by said illuminator and wherein said housing further permits the detection of a fluorescent response at a second wavelength λn. The negatively charged material includes (dsDNA coated) spherical AuNPs and graphene oxide (GO). The positively charged fluorescent material includes water soluble cationic conjugated polyelectrolytes (COPE) or positively charged peptide/polymer labeled with fluorescence dye. The sensor makes use of the FRET phenomenon between the primary and secondary sensing materials. The sensor allows making a distinction between living and dead bacteria and can measure the total bacteria count. A method for detecting bacteria utilizing the sensor is another part of the invention.
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公开(公告)号：US10654921B2
公开(公告)日：2020-05-19
申请号：US16321020
申请日：2017-07-26
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Simeon Cua , Andre Boon Hwa Choo , Heng Liang Tan , Wey Jia Fong , Vanessa Mei Yee Ding , Leonard Wen Yan Leong
IPC: A61K39/395 , C07K16/18 , A61K47/68 , A61P35/00 , G01N33/574 , A61K31/282 , A61K31/337 , A61K31/5377 , A61K38/17 , C07K14/705 , A61K39/00
Abstract: The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.
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公开(公告)号：US10647860B2
公开(公告)日：2020-05-12
申请号：US14350057
申请日：2012-10-04
Applicant: Agency for Science, Technology and Research
Inventor： Xu Li , Chaobin He , Siew Yee Wong
Abstract: The present invention relates to a method for forming a layered silicate/polymer composite, the composite comprising individual exfoliated silicate layers separated in a continuous polymer matrix, wherein the polymer is a hydrophobic polymer, the method comprising: exfoliating sheet silicate in water to form a silicate suspension; replacing the water in the silicate suspension by an organic solvent to form a silicate/organic solvent suspension; contacting the silicate/organic solvent suspension with a solution of a hydrophobic polymer precursor in an organic solvent to form a silicate/polymer precursor suspension; coating the silicate/polymer precursor suspension on a substrate; removing the organic solvents; curing the hydrophobic polymer precursor of the coating of the silicate/polymer precursor; and annealing the cured coating to form the layered silicate/polymer composite on the substrate.
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公开(公告)号：US10595527B2
公开(公告)日：2020-03-24
申请号：US15839402
申请日：2017-12-12
Applicant: International Business Machines Corporation , Agency for Science, Technology and Research
Inventor： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC: A01N25/10 , A01N37/26 , A01N43/50 , C07C279/10 , C08G69/26 , C08L79/02 , C08G73/02 , A01N47/44 , C08L101/00 , A61Q17/00
Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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