公开(公告)号：US10080738B2

公开(公告)日：2018-09-25

申请号：US15331939

申请日：2016-10-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K31/407 ,  A61K47/10 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K47/12 ,  A61M37/00

CPC classification number: A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

公开(公告)号：US20180015049A1

公开(公告)日：2018-01-18

申请号：US15547645

申请日：2016-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Masahiro SATO ,  Yasuhisa KOSE ,  Takaaki YOSHINAGA

IPC: A61K9/70 ,  A61K31/045 ,  A61F13/00 ,  A61F13/02 ,  A61K47/34 ,  A61K31/618

CPC classification number: A61K9/7053 ,  A61F13/00063 ,  A61F13/0243 ,  A61F13/0253 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K47/06 ,  A61K47/34 ,  A61L15/00 ,  B32B5/02 ,  B32B27/00

Abstract: Disclosed is an adhesive patch having a support and an adhesive agent layer laminated on the support, wherein the support consists of spunlace nonwoven fabric, the adhesive agent layer comprises an SIS block copolymer and liquid paraffin, the adhesive patch has a first direction, which is a predetermined reference axis direction, and a second direction, which is orthogonal to the first direction, and a bending resistance in the first direction of the adhesive patch is 18 to 30 mm.

公开(公告)号：USD800573S1

公开(公告)日：2017-10-24

申请号：US29582203

申请日：2016-10-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Sayaka Mochizuki ,  Shigeo Kusumi

公开(公告)号：US09775799B2

公开(公告)日：2017-10-03

申请号：US14766893

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya Sugahara ,  Kazuya Machida

IPC: A61K38/00 ,  A61K9/00 ,  A61K47/12 ,  A61K47/18 ,  A61L31/16 ,  A61M5/32 ,  A61K47/02 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K38/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61L31/16 ,  A61L2300/214 ,  A61M5/329 ,  A61M37/0015 ,  Y02A50/389

Abstract: Disclosed is a microneedle coating composition comprising a physiologically active substance (excluding Japanese encephalitis vaccine antigen), a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.

公开(公告)号：US20170233343A1

公开(公告)日：2017-08-17

申请号：US15502793

申请日：2015-10-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi SONOBE ,  Takashi YASUKOCHI ,  Yasunori TAKADA ,  Kenji ATARASHI ,  Motohiro SUZUKI ,  Shinichi YOKOTA

IPC: C07D213/75

CPC classification number: C07D213/75 ,  A61K31/44

Abstract: The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein R is a hydrogen atom, a C1-6 alkyl group optionally substituted with one or more hydroxyl groups, a C1-6 alkoxy group, or a cyano group.

公开(公告)号：US20170172981A1

公开(公告)日：2017-06-22

申请号：US15454066

申请日：2017-03-09

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki SUZUKI ,  Hiroaki OKUTSU ,  Takashi YASUKOCHI ,  Yasunori TAKADA

IPC: A61K31/407 ,  A61M37/00 ,  A61K47/12 ,  A61K9/70 ,  A61K47/14

Abstract: A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.

公开(公告)号：USD775964S1

公开(公告)日：2017-01-10

申请号：US29530495

申请日：2015-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Sayaka Mochizuki ,  Shigeo Kusumi

公开(公告)号：USD774400S1

公开(公告)日：2016-12-20

申请号：US29530477

申请日：2015-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Masaki Miyazaki ,  Shigeo Kusumi

公开(公告)号：US20160263363A1

公开(公告)日：2016-09-15

申请号：US15032709

申请日：2014-11-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shunsuke ARAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

Abstract translation: 施用器被构造成通过皮肤用皮肤穿刺用微针将活性成分转移到皮肤中。 涂抹器包括活塞板，活塞板在活塞板的主体的下表面侧设置有第一突出部和第二突出部。 微针设置在第一突出部的表面上。 第二突起部分设置在与第一突出部分间隔开的第一突出部分的周边。

公开(公告)号：US20160144160A1

公开(公告)日：2016-05-26

申请号：US14899148

申请日：2014-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023

Abstract: An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface.

Abstract translation: 用于将微针施加到皮肤的一个方面的涂抹器包括电阻部分，其被构造成施加抵抗沿着所述片材的主表面形成的具有多个微针的微针片的运动的阻力;以及弯曲部分，其被配置为弯曲经过的微针片 电阻部分，用于将微针从主表面上升。