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公开(公告)号:US20160175262A1
公开(公告)日:2016-06-23
申请号:US14974288
申请日:2015-12-18
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Yasuhisa KOSE , Takaaki YOSHINAGA
CPC classification number: A61K9/7061 , A61K31/618 , A61K47/14 , A61K47/26
Abstract: A gel patch includes a base fabric, an adhesive layer, and a release liner in this order, wherein the adhesive layer contains a physiologically active substance, a water-soluble (meth)acrylic polymer, water, a surfactant, and poly(methyl acrylate/2-ethylhexyl acrylate), and the surfactant comprises a polyethylene glycol fatty acid ester or a polyoxyethylene sorbitan fatty acid ester.
Abstract translation: 凝胶贴剂依次包括基底织物,粘合剂层和剥离衬垫,其中粘合剂层含有生理活性物质,水溶性(甲基)丙烯酸聚合物,水,表面活性剂和聚(丙烯酸甲酯 丙烯酸-2-乙基己酯),表面活性剂包括聚乙二醇脂肪酸酯或聚氧乙烯脱水山梨糖醇脂肪酸酯。
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公开(公告)号:US20170348248A1
公开(公告)日:2017-12-07
申请号:US15537952
申请日:2015-12-14
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Yasuhisa KOSE , Takaaki YOSHINAGA
IPC: A61K9/70 , A61K31/618 , A61K47/14 , A61K47/26
CPC classification number: A61K9/7061 , A61K31/618 , A61K47/14 , A61K47/26
Abstract: The present invention provides a gel patch comprising a base fabric, an adhesive layer, and a release liner in this order, wherein the adhesive layer contains a physiologically active substance, a water-soluble (meth)acrylic polymer, water, a surfactant, and poly(methyl acrylate/2-ethylhexyl acrylate), and the surfactant comprises a polyethylene glycol fatty acid ester or a polyoxyethylene sorbitan fatty acid ester.
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公开(公告)号:US20180015049A1
公开(公告)日:2018-01-18
申请号:US15547645
申请日:2016-02-05
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Kentaro NAKASHIMA , Masahiro SATO , Yasuhisa KOSE , Takaaki YOSHINAGA
IPC: A61K9/70 , A61K31/045 , A61F13/00 , A61F13/02 , A61K47/34 , A61K31/618
CPC classification number: A61K9/7053 , A61F13/00063 , A61F13/0243 , A61F13/0253 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K47/06 , A61K47/34 , A61L15/00 , B32B5/02 , B32B27/00
Abstract: Disclosed is an adhesive patch having a support and an adhesive agent layer laminated on the support, wherein the support consists of spunlace nonwoven fabric, the adhesive agent layer comprises an SIS block copolymer and liquid paraffin, the adhesive patch has a first direction, which is a predetermined reference axis direction, and a second direction, which is orthogonal to the first direction, and a bending resistance in the first direction of the adhesive patch is 18 to 30 mm.
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公开(公告)号:US20220125626A1
公开(公告)日:2022-04-28
申请号:US17430035
申请日:2020-02-14
Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.
Inventor: Kentaro NAKASHIMA , Keiichiro TSURUSHIMA , Takaaki YOSHINAGA
IPC: A61F7/02 , C09J129/04 , C08K5/12
Abstract: A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.
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公开(公告)号:US20160206569A1
公开(公告)日:2016-07-21
申请号:US14913455
申请日:2014-08-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Yasuhisa KOSE , Seiichiro TSURU , Shinji YAMASOTO , Takaaki YOSHINAGA
IPC: A61K9/70
CPC classification number: A61K9/7061 , A61L15/225 , A61L15/585 , A61L15/60 , C08F220/14 , C08L33/02 , C08L71/00 , C08L33/08 , C08F2220/1858
Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.
Abstract translation: 一种凝胶贴片,其包含支撑体上的膏药层,所述膏药层包含至少中和的聚丙烯酸,聚(丙烯酸甲酯/丙烯酸2-乙基己酯)乳液和水的混合物,其中所述聚(丙烯酸甲酯/ 丙烯酸乙基己酯)乳液是通过在介质沸点以上加热而蒸发残留物为57〜61%的乳液,其存在量为中和的聚丙烯酸的质量的至少2.5倍,优选至少3倍 酸。
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公开(公告)号:US20230093050A1
公开(公告)日:2023-03-23
申请号:US17798412
申请日:2021-02-04
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Kentaro NAKASHIMA , Kento ICHINOHE , Keiichiro TSURUSHIMA , Takaaki YOSHINAGA
IPC: C09J133/02 , C09J11/06 , C09J11/08 , C09J7/30
Abstract: A method for producing an adhesive layer composition for producing a cooling sheet including a backing layer, an adhesive layer, and a liner layer, the method comprising the step of:
mixing a composition to be mixed containing water, an alum, sodium edetate, a polyacrylic acid, and a neutralized polyacrylic acid such that a mixing temperature becomes 5 to 23° C., to obtain an adhesive layer composition, wherein
in the composition to be mixed,
a content of the water is 69 to 938.24% by mass relative to a total mass of the composition to be mixed,
a content of the alum is 0.18 to 0.42% by mass relative to the total mass of the composition to be mixed,
a content of the sodium edetate is 0.08 to 0.18% by mass relative to the total mass of the composition to be mixed, and
a mass ratio between the content of the alum and the content of the sodium edetate (the content of the alum:the content of the sodium edetate) is 1:1 to 5.25:1.-
公开(公告)号:US20200009075A1
公开(公告)日:2020-01-09
申请号:US16483510
申请日:2018-02-15
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Masakazu SAEKI , Takaaki YOSHINAGA
Abstract: A patch base comprises gelatin, polyvinyl alcohol, a methyl acrylate/2-ethylhexyl acrylate copolymer, and L-menthyl glyceryl ether, whereinrelative to the total mass of the base,the content of the gelatin is 1.5 to 6% by mass,the content of the polyvinyl alcohol is 0.5 to 8% by mass, andthe content of the methyl acrylate/2-ethylhexyl acrylate copolymer is 0.5 to 13% by mass.
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公开(公告)号:US20160113877A1
公开(公告)日:2016-04-28
申请号:US14894188
申请日:2014-05-30
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Takaaki YOSHINAGA , Yuko NAGASE , Toshihiro NAKANISHI
IPC: A61K9/20 , A61K31/4439 , A61K47/44 , A61K47/38 , A61K47/14
CPC classification number: A61K9/2086 , A61K9/006 , A61K9/2054 , A61K31/4439 , A61K47/14 , A61K47/26 , A61K47/38 , A61K47/44
Abstract: An oral cavity patch comprising: a drug layer and an adhesive layer, wherein the drug layer comprises a drug-release-controlling agent consisting of at least one selected from the group consisting of a hydroxyalkyl alkyl cellulose, hydroxypropyl cellulose, a sodium carboxyalkyl cellulose, ethyl cellulose, hydrogenated castor oil, and a sucrose fatty acid ester.
Abstract translation: 一种口腔贴剂,其包含:药物层和粘合剂层,其中所述药物层包含药物释放控制剂,所述药物释放控制剂由选自羟烷基烷基纤维素,羟丙基纤维素,羧基烷基纤维素钠, 乙基纤维素,氢化蓖麻油和蔗糖脂肪酸酯。
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