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公开(公告)号：US10344073B2
公开(公告)日：2019-07-09
申请号：US15110111
申请日：2015-01-08
Inventor： Abraham Rutenberg , Ronny Uzana , Michal Lotem , Arthur Machlenkin , Galit Eisenberg , Tamar Peretz-Yablonsky , Shoshana Frankenburg , Roni Engelstein
IPC: C07K14/705 , C07K14/725 , A61K39/39 , A61K39/395 , A61K35/17 , C12N5/0783 , A61K45/06 , C07K16/28 , A61K39/00
Abstract: Provided is directed to the field of immunotherapy. Specifically, provided are compositions and methods for improved T cell modulation ex vivo and in vivo and for the treatment of cancer and other pathologies. More specifically, embodiments of the subject matter are directed to the use of soluble NTB-A polypeptides or agonists thereof for the treatment of cancer patients, for preventing and treating cytopenia in susceptible patients, and for the ex vivo preparation of improved cell compositions.
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公开(公告)号：US10328098B2
公开(公告)日：2019-06-25
申请号：US15206280
申请日：2016-07-10
Applicant: Hadasit Medical Research Services and Development Ltd. , Ben-Gurion University of the Negev Research and Development Authority
Inventor： Yaron Ilan , Gadi Lalazar , Eyal Shteyer , Ami Ben-Ya'acov , Smadar Cohen , Tsiona Elkayam
IPC: A61K31/738 , A61K31/734 , A61L27/20 , A61L31/04 , A61P1/16
Abstract: The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.
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公开(公告)号：US20190167179A1
公开(公告)日：2019-06-06
申请号：US16323791
申请日：2017-08-07
Inventor： Shahar ARZY
IPC: A61B5/00
Abstract: A method of neuropsychological analysis comprises: presenting to a subject, by a user interface, a subject-specific cognitive task having at least one task portion selected from the group consisting of a time-domain task portion, a space-domain task portion, and a person-domain task portion. The method also comprises receiving responses entered by the subject using the user interface for each of the task portions, representing the responses as a set of parameters, and classifying the subject into one of a plurality of cognitive function classification groups, based on the set of parameters.
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公开(公告)号：US10307462B2
公开(公告)日：2019-06-04
申请号：US14534394
申请日：2014-11-06
Inventor： Dina Ben Yehuda , Ihab Abd-Elrahman , Riki Perlman , Marjorie Pick
IPC: A61K39/00 , A61K38/17 , C12N5/078 , C12N5/0789 , A61K45/06 , A61K35/28 , A61K35/545
Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.
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公开(公告)号：US10087232B2
公开(公告)日：2018-10-02
申请号：US14773349
申请日：2014-03-06
Inventor： Yaron Ilan , Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Tami Ariel , Svetlana Gingis-Velitski
IPC: A61K39/00 , A61K38/00 , A61K38/16 , C07K14/705 , C07K14/525 , C12N15/82 , A61K9/00 , A61K36/81 , C07K16/24
Abstract: A method of treating a TNF Alpha associated medical condition selected from the group consisting of obesity, metabolic syndrome, diabetes and a liver disease or disorder is provided. The method comprising enterally administering to a subject in need thereof a therapeutically effective amount of plant cells expressing a TNF Alpha polypeptide inhibitor, thereby treating the TNF Alpha associated medical condition.
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Patent Agency Ranking
公开(公告)号：US10064927B2
公开(公告)日：2018-09-04
申请号：US15051205
申请日：2016-02-23
Inventor： Tamar Peretz , Michal Lotem , Arthur Machlenkin , Shoshana Frankenburg , Inna Ben David , Anna Kuznetz , Yael Gelfand , Galit Eisenberg , Merav Darash Yahana
IPC: A61K39/00 , C12N5/09 , C12Q1/6886 , G01N33/574
Abstract: The present invention relates to cancer immunotherapy, specifically to allogeneic tumor cell vaccines. According to some embodiments, the invention provides novel cell lines useful as therapeutic cell vaccine compositions. The invention further provides advantageous screening methods and means for identifying patients amenable for treatment with partially Human Leukocyte Antigen (HLA) matched allogeneic cell vaccines. Therapeutic compositions and methods for use in proliferative disorders are further provided.
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公开(公告)号：US20180187269A1
公开(公告)日：2018-07-05
申请号：US15896902
申请日：2018-02-14
Inventor： Asher SALMON , Tamar PERETZ
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/156 , C12Q2600/158
Abstract: The present invention relates to diagnostic compositions methods and kits for the detection of carriers of mutations in the BRCA1 and BRCA2 genes. The detection is based on the use of detecting nucleic acids or amino acid based molecules, specific for determination of the expression of at least six marker genes of the invention, in a test sample. The invention thereby provides methods compositions and kits for the diagnosis of cancerous disorders associated with mutations in the BRCA1 and BRCA2 genes, specifically, of ovarian and breast cancer.
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168.发明授权公开(公告)号：US09944988B2
公开(公告)日：2018-04-17
申请号：US15256781
申请日：2016-09-06
Inventor： Rifaat Safadi
IPC: C07H21/02 , C12Q1/68 , A61K31/7088 , A61K45/06 , C12N15/113 , A61K31/713 , A61K31/7105
CPC classification number: C12Q1/6883 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12Q2600/158
Abstract: The present invention provides a method of diagnosing and/or monitoring a liver disorder in a subject. The method calls for isolating an immune cell population from a biological sample of the subject; and detecting expression level of an NLGn4 gene product in the immune cell population using NLGn4 specific primers or NLGn4 specific probes.
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公开(公告)号：US20180085347A1
公开(公告)日：2018-03-29
申请号：US15560170
申请日：2016-03-24
Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Sara GOLDSTEIN , Amram SAMUNI , Neville BERKMAN
IPC: A61K31/40
CPC classification number: A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/45
Abstract: Cyclic nitroxide compounds including, but not limited to, compounds having the general formula I: wherein the dashed line and R1-R8 are as defined herein, are disclosed herein for use in treating diseases and disorders of the respiratory tract and/or respiratory tract remodeling.
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公开(公告)号：US20170199190A1
公开(公告)日：2017-07-13
申请号：US15470926
申请日：2017-03-28
Inventor： Benjamin Eithan REUBINOFF , Nurit YACHIMOVICH-COHEN , Limor MATZRAFI
IPC: G01N33/569 , C12N5/079 , G01N33/58
CPC classification number: G01N33/56966 , C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/45 , C12N2509/00 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/4704 , G01N2333/46
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
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