公开(公告)号：US20100061984A1

公开(公告)日：2010-03-11

申请号：US12161192

申请日：2007-01-22

Applicant: Mark L. Greene ,  Sandra W. Saouaf ,  Bin Li ,  Hongtao Zhang ,  Wayne Hancock

Inventor： Mark L. Greene ,  Sandra W. Saouaf ,  Bin Li ,  Hongtao Zhang ,  Wayne Hancock

IPC: A61K39/395 ,  A61K39/00 ,  A61K35/14 ,  A61K38/12 ,  A61K48/00 ,  A61K31/675 ,  A61K31/519 ,  A61K31/52 ,  A61K31/4355 ,  A61K31/436

CPC classification number: C12N5/0636 ,  A61K31/19 ,  A61K35/17 ,  A61K38/1793 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/39 ,  A61K49/0008 ,  C12N15/1137 ,  C12N2310/14 ,  A61K2300/00

Abstract: Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.

Abstract translation: 公开了治疗自身免疫性疾病，冠状动脉疾病，过敏症状，同种异体移植排斥败血症/中毒性休克的方法。 一些方法包括施用一种或多种调节组合物以通过与T抑制刺激和/或抗原组合增加FOXP3的乙酰化水平和/或蛋白水平来激活T抑制细胞。 一些方法包括施用一种或多种调节组合物以通过增加FOXP3的乙酰化水平和/或蛋白水平来激活T抑制细胞。 一些方法包括施用可结合GITR配体的可溶性GITR或抗体。 疫苗接种方法也公开了治疗癌症，感染性疾病和免疫缺陷的方法。 所述方法包括施用一种或多种调节组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平来灭活T抑制细胞。 公开了改进的疫苗和疫苗接种方法。 公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。

公开(公告)号：US20100041729A1

公开(公告)日：2010-02-18

申请号：US12440331

申请日：2007-09-10

Applicant: Yingping Guo ,  Genhui Chen ,  Bin Li

Inventor： Yingping Guo ,  Genhui Chen ,  Bin Li

IPC: A61K31/407 ,  C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R1, R2, and R3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.

Abstract translation: 本发明提供通式I的二硫代环吡咯酮化合物及其盐，其中A为硫或碳，R1，R2和R3选自本文定义的基团，其中当A为硫时，B为氧， n = 1或2，当A为碳时，B为氧或硫，n = 1。 这些化合物可用于预防和治疗诸如HIV感染的微生物感染，以及用于治疗血液病症，例如中性白细胞减少症。 特别地，这些化合物可用于制备用于增加白细胞的药物。

公开(公告)号：US07636781B2

公开(公告)日：2009-12-22

申请号：US10542593

申请日：2003-09-17

Applicant: Bin Li ,  Xuegui Cao ,  Shaowen Ma ,  Zhong Chen ,  Baojiang Chen

Inventor： Bin Li ,  Xuegui Cao ,  Shaowen Ma ,  Zhong Chen ,  Baojiang Chen

IPC: G06F15/167 ,  G06G15/16 ,  G06F11/00

CPC classification number: H04L47/825 ,  H04L45/04 ,  H04L47/17 ,  H04L47/2408 ,  H04L47/2441 ,  H04L47/245 ,  H04L47/2491 ,  H04L47/39 ,  H04L47/70 ,  H04L47/724 ,  H04L47/745 ,  H04L47/765 ,  H04L47/786 ,  H04L47/822 ,  H04L47/829

Abstract: The present invention relates to a system for implementing resource allocation in network communication and a method thereof. It effectively solves the end-to-end QOS problem through dividing a communication network into a plurality of QOS domains and managing them. In the present invention, only end-to-end path information is maintained at the QER of the QOS domain that is directly connected with the source/destination terminal, while only edge-to-edge resource reservation information for aggregate flows is maintained at other QERs, thus significantly reducing flow state information maintained at the network nodes as well as overhead of signaling protocol processing and storage at the network nodes.

Abstract translation: 本发明涉及网络通信中资源分配实现的系统及其方法。 通过将通信网络划分为多个QOS域并进行管理，可以有效地解决端到端QOS问题。 在本发明中，只有端到端路径信息维持在与源/目的终端直接连接的QOS域的QER上，而仅用于集合流的边到边资源预留信息被保持在其他 QER，从而显着地减少了在网络节点处维护的流状态信息以及网络节点处的信令协议处理和存储的开销。

公开(公告)号：US07620123B2

公开(公告)日：2009-11-17

申请号：US12166702

申请日：2008-07-02

Applicant: Bin Li ,  Gregory S. Sternberg ,  Philip J. Pietraski

Inventor： Bin Li ,  Gregory S. Sternberg ,  Philip J. Pietraski

IPC: H03D1/24

CPC classification number: H04L27/38 ,  H04L1/20

Abstract: An improved receiver and method estimate one or more parameters, such as amplitude and signal-to-noise ratio, of a received signal, such as an M-QAM or q-ASK signal. The amplitude of an M-QAM signal is estimated based upon known or ascertainable phase information regarding a plurality of transmitted symbols. The amplitude of a q-ASK signal is estimated based upon known or ascertainable magnitude information regarding a plurality of transmitted symbols. In another embodiment, the amplitude of an M-QAM or q-ASK signal is estimated based on statistical knowledge of the amplitude of the transmitted symbols. Other embodiments estimate amplitude, noise power, and signal-to-noise ratio of a received signal utilizing second-order and fourth-order moments of received samples, a maximum likelihood searching process, or a Kurtosis estimation process.

Abstract translation: 改进的接收机和方法估计诸如M-QAM或q-ASK信号的接收信号的一个或多个参数，例如振幅和信噪比。 基于关于多个发送符号的已知或可确定的相位信息来估计M-QAM信号的幅度。 基于关于多个发送符号的已知或可确定的幅度信息来估计q-ASK信号的幅度。 在另一个实施例中，M-QAM或q-ASK信号的振幅基于所发送符号的幅度的统计知识来估计。 其他实施例使用接收样本的二阶和四阶矩，最大似然搜索处理或峰度估计过程来估计接收信号的幅度，噪声功率和信噪比。

公开(公告)号：US20090264644A1

公开(公告)日：2009-10-22

申请号：US12084959

申请日：2006-11-28

Applicant: Genhui Chen ,  Bin Li ,  John M. Webster ,  Kaiji Hu ,  Jianxiong Li

Inventor： Genhui Chen ,  Bin Li ,  John M. Webster ,  Kaiji Hu ,  Jianxiong Li

IPC: C07D269/00 ,  A61P31/00 ,  A61P35/00

CPC classification number: C07D269/00

Abstract: The invention is drawn to novel macrolide compounds of formula I having antibiotic and antineoplastic activities, useful as medicaments and/or agrochemicals for microorganism infections, in particularly for infectious diseases involving drug-resistant Staphylococcus, and for treatment of human and animal cancers.

Abstract translation: 本发明涉及具有抗生素和抗肿瘤活性的新型的具有抗生素和抗肿瘤活性的大环内酯类化合物，可用作微生物感染的药物和/或农药，特别是涉及耐药性葡萄球菌的感染性疾病，以及用于治疗人和动物癌症。

公开(公告)号：US20090190645A1

公开(公告)日：2009-07-30

申请号：US12419333

申请日：2009-04-07

Applicant: Bin Li ,  Robert A. DiFazio ,  Jung-Lin Pan ,  Alexander Reznik ,  John David Kaewell, JR. ,  Peter Edward Becker

Inventor： Bin Li ,  Robert A. DiFazio ,  Jung-Lin Pan ,  Alexander Reznik ,  John David Kaewell, JR. ,  Peter Edward Becker

IPC: H04L25/49 ,  H03H7/30

CPC classification number: H04L25/03159 ,  H04B17/336

Abstract: A receiver or an integrated circuit (IC) incorporated therein includes a fast Fourier transform (FFT)-based (or hybrid FFT-based) sliding window block level equalizer (BLE) for generating equalized samples. The BLE includes a noise power estimator, first and second channel estimators, an FFT-based chip level equalizer (CLEQ) and a channel monitor unit. The noise power estimator generates a noise power estimate based on two diverse sample data streams. The channel estimators generate respective channel estimates based on the sample data streams. The channel monitor unit generates a first channel monitor signal including truncated channel estimate vectors based on the channel estimates, and a second channel monitor signal which indicates an approximate rate of change of the truncated channel estimate vectors. The FFT-based CLEQ generates the equalized samples based on the noise power estimate, one-block samples of the first and second sample data streams, the channel estimates and the monitor signals.

Abstract translation: 结合在其中的接收器或集成电路（IC）包括用于产生均衡样本的基于快速傅立叶变换（FFT）（或基于混合FFT）的滑动窗口块级均衡器（BLE）。 BLE包括噪声功率估计器，第一和第二信道估计器，基于FFT的码片级均衡器（CLEQ）和信道监视器单元。 噪声功率估计器基于两个不同的采样数据流产生噪声功率估计。 信道估计器基于样本数据流生成相应的信道估计。 信道监视单元基于信道估计产生包括截断的信道估计向量的第一信道监视信号，以及指示截断的信道估计向量的近似变化率的第二信道监视信号。 基于FFT的CLEQ基于噪声功率估计，第一和第二采样数据流的一个块采样，信道估计和监视信号来生成均衡的采样。

公开(公告)号：USD595353S1

公开(公告)日：2009-06-30

申请号：US29304852

申请日：2008-03-07

Applicant: Bin Li

Designer： Bin Li

公开(公告)号：US07524628B2

公开(公告)日：2009-04-28

申请号：US09977716

申请日：2001-10-15

Applicant: Mark I. Greene ,  Hong Tao Zhang ,  Bin Li ,  Qindu Liu ,  Ramchandran Murali

Inventor： Mark I. Greene ,  Hong Tao Zhang ,  Bin Li ,  Qindu Liu ,  Ramchandran Murali

IPC: C12Q1/68 ,  C12P19/34 ,  G01N33/53

CPC classification number: C07K5/1013 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/32 ,  C07K2319/32 ,  G01N33/532 ,  G01N33/58 ,  G01N33/6857 ,  G01N33/6878 ,  G01N2500/04

Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR, CDR mimetic or engineered CDR structure attached to an oligonucleotide.

Abstract translation: 提供方法，系统和试剂盒，用于通过使用含有选定表位的单链Fv或与寡核苷酸连接的约束表位特异性CDR，CDR模拟或工程化CDR结构的表位检测器来检测在样品中表达选定表位的分子。

公开(公告)号：USD589088S1

公开(公告)日：2009-03-24

申请号：US29302807

申请日：2008-01-24

Applicant: Bin Li

Designer： Bin Li

公开(公告)号：US07502426B2

公开(公告)日：2009-03-10

申请号：US10750203

申请日：2003-12-31

Applicant: Bin Li ,  Gregory S. Sternberg ,  Philip J. Pietraski

Inventor： Bin Li ,  Gregory S. Sternberg ,  Philip J. Pietraski

IPC: H03D1/24

CPC classification number: H04L27/38 ,  H04L1/20

Abstract: An improved system and method for estimating one or more parameters, such as amplitude and signal-to-noise ratio, of a received signal, such as an M-QAM or q-ASK signal, is set forth herein. The amplitude of an M-QAM signal is estimated based upon known or ascertainable phase information regarding a plurality of transmitted symbols. The amplitude of a q-ASK signal is estimated based upon known or ascertainable magnitude information regarding a plurality of transmitted symbols. In another embodiment, the amplitude of an M-QAM or q-ASK signal is estimated based on statistical knowledge of the amplitude of the transmitted symbols. Other embodiments of the present invention estimate amplitude, noise power, and signal-to-noise ratio of a received signal utilizing second-order and fourth-order moments of received samples, a maximum likelihood searching process, or a Kurtosis estimation process.

Abstract translation: 本文阐述了用于估计接收信号（诸如M-QAM或q-ASK信号）的一个或多个参数（诸如振幅和信噪比）的改进的系统和方法。 基于关于多个发送符号的已知或可确定的相位信息来估计M-QAM信号的幅度。 基于关于多个发送符号的已知或可确定的幅度信息来估计q-ASK信号的幅度。 在另一个实施例中，M-QAM或q-ASK信号的振幅基于所发送符号的幅度的统计知识来估计。 本发明的其他实施例使用接收样本的二阶和四阶矩，最大似然搜索处理或者峰度估计过程来估计接收信号的幅度，噪声功率和信噪比。