公开(公告)号：US20090137548A1

公开(公告)日：2009-05-28

申请号：US12087290

申请日：2006-12-29

Applicant: Amjad Ali ,  Zhijian Lu ,  Peter J. Sinclair ,  Yi-Heng Chen ,  Cameron J. Smith ,  Hong Li

Inventor： Amjad Ali ,  Zhijian Lu ,  Peter J. Sinclair ,  Yi-Heng Chen ,  Cameron J. Smith ,  Hong Li

IPC: C07D263/20 ,  A61K31/421 ,  A61K31/454 ,  A61K31/427 ,  C07D413/10 ,  C07D417/10 ,  A61P9/10

CPC classification number: C07D263/20 ,  C07D263/24 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14

Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.

Abstract translation: 具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于升高HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。 化合物具有通过单键连接的3个环状基团，例如三苯基，其直接连接到式I的环或连接在位置B.

公开(公告)号：US20090064293A1

公开(公告)日：2009-03-05

申请号：US11850542

申请日：2007-09-05

Applicant: Hong Li ,  Rita H. Wouhaybi

Inventor： Hong Li ,  Rita H. Wouhaybi

IPC: H04L9/32

CPC classification number: H04L63/105 ,  G06F21/55 ,  G06Q10/10

Abstract: Machine-readable media, methods, apparatus and system for a community-based trust are provided. In an embodiment, it may be determined whether a requesting node obtains a trust from a targeting node through an endorsement from an intermediate node. If the requesting node obtains the trust through the endorsement from the intermediate node, an intermediate trust level that indicates how much the targeting node trusts the intermediate node may be obtained; and a new trust level that indicates how much the targeting node trusts the requesting node may be calculated based upon the intermediate trust level.

Abstract translation: 提供了用于基于社区的信任的机器可读介质，方法，装置和系统。 在一个实施例中，可以确定请求节点是否通过来自中间节点的认可从目标节点获得信任。 如果请求节点通过来自中间节点的认可获得信任，则可以获得指示目标节点信任中间节点多少的中间信任级别; 以及指示目标节点信任请求节点多少的新信任级别可以基于中间信任级别来计算。

公开(公告)号：US20090047284A1

公开(公告)日：2009-02-19

申请号：US11985984

申请日：2007-11-19

Applicant: Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

Inventor： Linda Fredriksson ,  Hong Li ,  Christina Fieber ,  Xuri Li ,  Ulf Eriksson

IPC: A61K39/395 ,  A61K38/48 ,  C07K16/18 ,  A61P7/00

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K14/49 ,  C07K14/8132 ,  C07K16/40 ,  C12N9/6459 ,  C12N9/99 ,  C12Y304/21069

Abstract: Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.

Abstract translation: 抑制血管发生的方法包括施用组织纤溶酶原激活剂（tPA）抑制剂和适用于包含tPA抑制剂的方法的药物组合物。 还提供了用于刺激血管生成的方法，其包括向有需要的患者施用tPA，以及包含用于刺激方法的有效量的tPA的药物组合物。 本发明公开了tPA是特异性PDGF-C活化蛋白酶，PDGF-CC中的CUB结构域与蛋白酶直接相互作用，是有效的蛋白水解所必需的，而释放的CUB结构域是tPA抑制剂。 优选地，本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

公开(公告)号：US20080146430A1

公开(公告)日：2008-06-19

申请号：US11610761

申请日：2006-12-14

Applicant: Hong Li ,  Cheryl A. Richards

Inventor： Hong Li ,  Cheryl A. Richards

IPC: C03C3/091 ,  C03C3/093 ,  C03C13/00 ,  C03C13/02

CPC classification number: C03C3/118 ,  C03C3/091 ,  C03C13/00 ,  H05K1/0366

Abstract: Glass compositions are provided that are useful in electronic applications, e.g., as reinforcements in printed circuit board substrates. Reduced dielectric constants are provided relative to E-glass, and fiber forming properties are provided that are more commercially practical than D-glass.

Abstract translation: 提供了可用于电子应用的玻璃组合物，例如作为印刷电路板基底中的增强物。 提供了相对于E玻璃的降低的介电常数，并且提供了比D玻璃更商业上实用的纤维形成性能。

公开(公告)号：US20080139720A1

公开(公告)日：2008-06-12

申请号：US11986313

申请日：2007-11-20

Applicant: Hong Li ,  Robert A. Montague ,  Cheryl A. Richards ,  Nikita Sergeevitch Shelekhov ,  Natalia Aleksandrovna Kazachenok

Inventor： Hong Li ,  Robert A. Montague ,  Cheryl A. Richards ,  Nikita Sergeevitch Shelekhov ,  Natalia Aleksandrovna Kazachenok

IPC: C08K3/22

CPC classification number: C09C3/10 ,  C01P2002/82 ,  C01P2002/88 ,  C01P2004/04 ,  C01P2006/10 ,  C01P2006/40 ,  C08K9/04 ,  C08K9/08 ,  C09C3/12 ,  H05K1/0306 ,  H05K1/0373 ,  H05K2201/0116 ,  H05K2203/121 ,  Y10T428/31678 ,  Y10T428/31692

Abstract: The present invention relates to materials comprising organic-inorganic polymeric networks. In some embodiments, the present invention provides an organic-inorganic composite material comprising an inorganic metal oxide matrix interpenetrating with a polymeric phase. Additionally, the present invention provides methods of producing organic-inorganic composite materials.

Abstract translation: 本发明涉及包含有机 - 无机聚合物网络的材料。 在一些实施方案中，本发明提供了包含与聚合物相互渗透的无机金属氧化物基质的有机 - 无机复合材料。 另外，本发明提供了生产有机 - 无机复合材料的方法。

公开(公告)号：US20070165284A1

公开(公告)日：2007-07-19

申请号：US11333567

申请日：2006-01-17

Applicant: Hong Li ,  Gerhard Thompson ,  Chai Wu

Inventor： Hong Li ,  Gerhard Thompson ,  Chai Wu

IPC: H04N1/409

CPC classification number: H04N1/40062 ,  H04N1/409

Abstract: A method and system of processing a document, includes analyzing a characteristic of a first pixel in a document and at least one second pixel positioned near the first pixel, classifying a value of the first pixel in accordance with the analysis, and modifying the value of the first pixel based upon the classification.

Abstract translation: 一种处理文件的方法和系统，包括：分析文档中的第一像素的特性和位于第一像素附近的至少一个第二像素，根据分析对第一像素的值进行分类，并修改 基于分类的第一个像素。

公开(公告)号：US20070150431A1

公开(公告)日：2007-06-28

申请号：US10595765

申请日：2004-12-01

Applicant: Robert Jochemsen ,  Johannes Korst ,  Hong Li

Inventor： Robert Jochemsen ,  Johannes Korst ,  Hong Li

IPC: G06F17/30

CPC classification number: H04N21/2393

Abstract: The invention relates to real-time handling of data in more in particular, estimation of time needed to retrieve frames for video rendering, taking fragmentation of frames into account. Especially for data retrieval for trick-play, this is non-trivial, as it is not known on beforehand whether the frames to be retrieved are fragmented. Retrieval of non contiguously fragmented frames takes at least twice as much time as retrieval of a non-fragmented frame. The invention provides various advantageous embodiments, taking into account that when allocation units are substantially larger than the size of frames to be retrieved. An embodiment of the invention provides a method for accurate retrieval time estimation when trick play speed, allocation unit size, frame size and logical data distance between frames to retrieve is known.

Abstract translation: 本发明尤其涉及对数据的实时处理，尤其涉及检索用于视频呈现的帧所需的时间的估计，考虑到帧的碎片化。 特别是对于特技播放的数据检索，这是不平凡的，因为事先不知道要检索的帧是否被分段。 非连续分片帧的检索至少需要检索非碎片帧的两倍。 本发明提供了各种有利的实施例，考虑到当分配单元实质上大于要检索的帧的大小时。 本发明的一个实施例提供了一种当特技播放速度，分配单元大小，帧大小以及要检索的帧之间的逻辑数据距离是已知的时，精确检索时间估计的方法。

公开(公告)号：US20060188469A1

公开(公告)日：2006-08-24

申请号：US11345021

申请日：2006-01-31

Applicant: William Turnell ,  Vassil Vassilev ,  Kristin DeFife ,  Hong Li ,  Zaza Gomurashvili ,  Ramaz Katsarava

Inventor： William Turnell ,  Vassil Vassilev ,  Kristin DeFife ,  Hong Li ,  Zaza Gomurashvili ,  Ramaz Katsarava

IPC: A61K39/00

CPC classification number: A61K39/385 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K2039/544 ,  A61K2039/6093 ,  A61K2039/64 ,  C07K14/005 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: The present invention provides synthetic vaccine delivery compositions based on polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers for stimulating an immune response to a variety of pathogenic organisms and tumor cells in humans and other mammals. The vaccine delivery compositions are formulated as a liquid dispersion of polymer particles or molecules including class I or class II antigen peptides derived from organism or tumor cell proteins, which are taken up by antigen presenting cells of the mammal to induce an immune response in the mammal. Methods of inducing an immune response to the pathogenic organism or tumor cells in the invention compositions are also included.

Abstract translation: 本发明提供了基于聚酯酰胺（PEA），聚酯聚氨酯（PEUR）和聚酯尿素（PEU）聚合物的合成疫苗递送组合物，用于刺激人和其它哺乳动物中各种致病生物体和肿瘤细胞的免疫应答。 疫苗递送组合物被配制为聚合物颗粒或分子的液体分散体，包括衍生自生物或肿瘤细胞蛋白的I类或II类抗原肽，其被哺乳动物的抗原呈递细胞吸收以在哺乳动物中诱导免疫应答 。 还包括诱导本发明组合物中致病生物或肿瘤细胞的免疫应答的方法。

公开(公告)号：US20060085506A1

公开(公告)日：2006-04-20

申请号：US10965170

申请日：2004-10-14

Applicant: Don Meyers ,  Robert Johnson ,  Hong Li

Inventor： Don Meyers ,  Robert Johnson ,  Hong Li

IPC: G06F15/16

CPC classification number: H04L63/104 ,  H04L51/12 ,  H04L63/1425 ,  H04L63/1441

Abstract: Spam and other unwanted electronic-mail may be controlled by a system in which a given external message transfer agent using a given Internet protocol address and a given domain name is limited in the number of connections that it may make and the number of messages it may deliver over a given time period. Based on the performance of that external message transfer agent, the passage of time and the number of connections, its assigned connection limit may be increased so that progressively trust is increased and more message connections and a higher number of messages delivered may be permitted.

公开(公告)号：US20050259276A1

公开(公告)日：2005-11-24

申请号：US10403971

申请日：2003-03-28

Applicant: James Smith ,  Hong Li ,  Joseph Czyszczewski ,  Mikel Stanich

Inventor： James Smith ,  Hong Li ,  Joseph Czyszczewski ,  Mikel Stanich

IPC: G06F3/12 ,  H04N1/407 ,  H04N1/60

CPC classification number: H04N1/4072 ,  H04N1/60

Abstract: Methods, systems, and media to calibrate a reprographic system are disclosed. Embodiments of the invention may calibrate a component like scanner and/or printer in response to user input and/or coupling the component to the reprographic system. More specifically, embodiments may generate a curve that describes tone differences between an image scanned by a scanner or an image printed by the printer by comparing the outputs to acceptable tone descriptions for the image. Some embodiments comprise a graphical user interface (GUI) to communicate with the user, allowing the user to select user preference curves to change, for example, the brightness of an image being copied. Some embodiments incorporate network and phone system interfaces to communicate with remote components as well as to receive input from and/or output to other systems via email, facsimile, etc.

Abstract translation: 公开了用于校准复制系统的方法，系统和介质。 本发明的实施例可以响应于用户输入和/或将组件耦合到复制系统来校准诸如扫描仪和/或打印机的组件。 更具体地，实施例可以生成描述由扫描仪扫描的图像或由打印机打印的图像之间的色差的曲线，通过将输出与图像的可接受的色调描述进行比较。 一些实施例包括与用户通信的图形用户界面（GUI），允许用户选择用户偏好曲线来改变例如被复制的图像的亮度。 一些实施例将网络和电话系统接口与远程组件进行通信，以及通过电子邮件，传真等从其他系统接收和/或输出输入。