公开(公告)号：US10407484B2

公开(公告)日：2019-09-10

申请号：US15256152

申请日：2016-09-02

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Yuwen Zhu ,  Barish H. Edil ,  Richard D. Schulick ,  Alessandro Paniccia ,  Michelle Koenig ,  Alexander C. Schulick

IPC: C07K16/00 ,  C12P21/08 ,  C07K14/705 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K14/725 ,  A61K47/68 ,  A61K47/69

Abstract: The present disclosure relates to compositions and methods for modulating T-cell mediated immune response in a subject in need thereof. The method includes administering to the subject an effective amount of a CD112R protein, a fusion polypeptide, a complex including CD112R and a second protein, or an anti-CD112R antibody of the present disclosure.

公开(公告)号：US20190270677A1

公开(公告)日：2019-09-05

申请号：US16319734

申请日：2017-07-21

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： ZHIYONG REN ,  MITCHELL TYLER HUGGINS ,  JUSTIN C. BIFFINGER ,  COREY T. LOVE ,  SE-HEE LEE ,  JUSTIN M. WHITELEY

IPC: C04B35/83 ,  H01M4/587 ,  H01M10/0525 ,  C04B35/64 ,  C04B35/626 ,  H01M10/0562 ,  H01M10/0568 ,  C12P1/02

Abstract: The invention provides filamentous organism-derived carbonaceous materials doped with organic and/or inorganic compounds, and methods of making the same. In certain embodiments, these carbonaceous materials are used as electrodes in solid state batteries and/or lithium-ion batteries. In another aspect, these carbonaceous materials are used as a catalyst, catalyst support, adsorbent, filter and/or other carbon-based material or adsorbent. In yet another aspect, the invention provides battery devices incorporating the carbonaceous electrode materials.

公开(公告)号：US10404224B2

公开(公告)日：2019-09-03

申请号：US15828353

申请日：2017-11-30

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Taylor W. Barton ,  Prathamesh H. Pednekar

IPC: H03F3/18 ,  H03F3/189 ,  H03F1/56 ,  H03F3/20 ,  H03F3/24 ,  H03F3/60

Abstract: In various implementations of a load modulated balanced amplifier (LMBA), a control signal is generated (e.g., automatically generated) based at least in part on an input signal. The LBMA generally comprises a balanced amplifier, an input splitter, and a control path. A common theme of the different variants described below is that we use a nonlinear characteristic to generate a power-dependent asymmetry in the relative output power levels of the balanced and control amplifiers. This power-depended asymmetry results in dynamic load modulation of the balanced amplifiers, which in turn provides improved efficiency. In one implementation, for example, an LMBA comprises a pair of primary amplifiers collectively providing a balanced amplifier and a control amplifier coupled to the balanced amplifier and adapted to provide a control signal to the balanced amplifier. The control amplifier is adapted to automatically generate the control signal based at least in part upon the input signal to provide load modulation of the balanced amplifier.

公开(公告)号：US10400309B2

公开(公告)日：2019-09-03

申请号：US14915573

申请日：2014-08-28

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Alan W. Weimer ,  Aaron Palumbo ,  Illias Hischier ,  Boris A. Chubukov ,  Scott C. Rowe ,  Richard Fisher ,  Arto J. Groehn

IPC: C22B26/22 ,  C01B21/06 ,  C01B21/068 ,  C01B21/072 ,  C22B5/10 ,  C22B19/20 ,  B01D53/00 ,  C22B1/14 ,  C22B5/16

Abstract: Methods, systems, and components suitable for carbothermal reduction processes are disclosed. Exemplary systems include a reactor, such as hybrid solarthermal-electric reactor, a solar thermal reactor, an electric reactor, or a reactor heated by gas combustion, a pellet source, a gas reactant source, and a vacuum source. The reactor can operate as a moving bed or pseudo moving bed reactor.

公开(公告)号：US20190262315A1

公开(公告)日：2019-08-29

申请号：US16168896

申请日：2018-10-24

Applicant: MEDIVATION PROSTATE THERAPEUTICS LLC ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Andrew A. Protter ,  Jennifer Richer ,  Dawn Cochrane

IPC: A61K31/4184 ,  A61K31/4166

Abstract: The disclosure describes compounds useful for treating breast cancers.

公开(公告)号：US10363288B2

公开(公告)日：2019-07-30

申请号：US15541074

申请日：2016-01-13

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate ,  NATIONAL JEWISH HEALTH

Inventor： Aaron Michels ,  John Kappler ,  Peter A. Gottlieb

IPC: G01N33/50 ,  A61K38/28 ,  C07K14/62

Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.

公开(公告)号：US20190194693A1

公开(公告)日：2019-06-27

申请号：US16275465

申请日：2019-02-14

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Ryan T. Gill ,  Andrew Garst

IPC: C12N15/90 ,  C40B40/08 ,  C12N15/10 ,  C12N15/11 ,  C12N9/22

Abstract: Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.

公开(公告)号：US20190194650A1

公开(公告)日：2019-06-27

申请号：US16295393

申请日：2019-03-07

Applicant: The Regents of the University of Colorado, a body corporate ,  Inscripta, Inc.

Inventor： Ryan T. Gill ,  Andrew Garst ,  Tanya Elizabeth Warnecke Lipscomb ,  Marcelo Colika Bassalo ,  Ramsey Ibrahim Zeitoun

IPC: C12N15/10 ,  C12N15/11

CPC classification number: C12N15/1065 ,  C12N15/102 ,  C12N15/1079 ,  C12N15/1082 ,  C12N15/11 ,  C12N2310/20 ,  C12Q2563/179

Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.

公开(公告)号：US20190180637A1

公开(公告)日：2019-06-13

申请号：US16215149

申请日：2018-12-10

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Meredith Mealer

IPC: G09B5/04 ,  G06F3/01

Abstract: Various embodiments of the present technology generally relate to virtual and augmented reality simulations. More specifically, some embodiments of the present technology generally relate to virtual and augmented reality simulations to improve resiliency for healthcare clinicians. Some embodiments provide for a VR training system to allow a realistic, immersive and safe environment for students or other trainees to encounter traumatic experiences. Exposure to trauma in a safe environment offers the opportunity for new and seasoned individual to build resilient skills through cognitive flexibility and reframing thus alleviating symptoms of burnout, PTSD, anxiety and depression that is caused by the work environment and critical encounters. The participant can be the ‘player’ within simulation hosting multiple virtual characters and/or multiple other ‘players’ for team building and organizational resilience.

公开(公告)号：US20190151147A1

公开(公告)日：2019-05-23

申请号：US16186030

申请日：2018-11-09

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Jeffrey Olson

IPC: A61F9/00 ,  A61F2/16

Abstract: An implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof. The substrate may be capable of capturing a target molecule present in the eye and/or from fluid of the eye (e.g., an intraocular target molecule). In some embodiments, the substrate has a relatively high affinity for a target molecule.