公开(公告)号：US20060057732A1

公开(公告)日：2006-03-16

申请号：US11225313

申请日：2005-09-12

申请人： Per Agvald ,  Dag Linnarsson ,  Christofer Adding ,  Lars Gustafsson ,  Kristofer Nilsson

发明人： Per Agvald ,  Dag Linnarsson ,  Christofer Adding ,  Lars Gustafsson ,  Kristofer Nilsson

IPC分类号： G01N33/48

CPC分类号： A61B5/082 ,  A61B5/0836 ,  Y10T436/177692

摘要： Pulmonary embolism in a human patient can be detected or confirmed by monitoring the level of endogenous NO in expired air, comparing the measured level with baseline values previously obtained for the same patient or baseline values representing a healthy population. The method can be used alone, or as a supplemental or adjunct step in traditional methods for diagnosing pulmonary embolism. Analysis of the obtained NO value, with consideration of the flow and resistance, can be used to indicate the severity of the pulmonary embolism.

摘要翻译： 可以通过监测呼出空气中内源性NO的水平来检测或确认人类患者的肺栓塞，将测量的水平与先前为同一患者获得的基线值或代表健康人群的基线值进行比较。 该方法可以单独使用，也可用作诊断肺栓塞的传统方法中的补充或辅助步骤。 分析获得的NO值，考虑流量和阻力，可用于指示肺栓塞的严重程度。

公开(公告)号：US09304100B2

公开(公告)日：2016-04-05

申请号：US13744533

申请日：2013-01-18

申请人： Niclas Roxhed ,  Goran Stemme ,  Hithesh K. Gatty

发明人： Niclas Roxhed ,  Goran Stemme ,  Hithesh K. Gatty

IPC分类号： G01N27/404 ,  G01N33/497

CPC分类号： G01N27/4045 ,  G01N33/497

摘要： A miniaturised electrochemical sensor for detection of a component in a gas is provided. The sensor comprises a reference electrode, a counter electrode and a structure comprising a plurality of passages delineated by walls extending along the passages. A working electrode covers the walls of the structure and a layer of an ionomer covers at least part of the working electrode along the walls of the structure. The layer of ionomer is in ion conducting contact with the electrodes. The disclosure further relates to a method of fabricating a miniaturised electrochemical sensor and to a device for measuring content of NO in exhaled breath comprising such a miniaturised electrochemical sensor.

摘要翻译： 提供了用于检测气体中的组分的小型化学电化学传感器。 传感器包括参比电极，对电极和包括沿着通道延伸的壁所描绘的多个通道的结构。 工作电极覆盖结构的壁，并且离子交换聚合物层沿着结构的壁覆盖工作电极的至少一部分。 离聚物层与电极离子导电接触。 本发明还涉及一种制造小型化学电化学传感器的方法和用于测量包含这种小型化学电化学传感器的呼出气体中的NO含量的装置。

公开(公告)号：USD752090S1

公开(公告)日：2016-03-22

申请号：US29469432

申请日：2013-10-10

申请人： Aerocrine AB

设计人： Fernanda Barbato

公开(公告)号：US08539809B2

公开(公告)日：2013-09-24

申请号：US12525301

申请日：2008-01-28

申请人： Tryggve Hemmingsson ,  Mats Carlsson

发明人： Tryggve Hemmingsson ,  Mats Carlsson

IPC分类号： G01N21/00

CPC分类号： G01N33/497

摘要： The present invention relates to the field of gas measurements, andmore specifically to the field of testing the measuring function of a measuring device (7) for gas measurements, the measuring device (7) including a gas sensor (9) generating at least one output signal. The method includes connecting at least one simulation signal to the measuring device (7) and/or feeding a gas mixture to the measuring device wherein the magnitude of the concentration of a gas to be measured in the gas mixture is known. The invention also relates to a simulation device (1) for connection to the measuring device (7) for gas measurements when testing the measuring function of the measuring device (7). The simulation device (1) generates at least one simulation signal which can attain at least one signal level, wherein a certain signal value corresponds to a certain gas concentration.

摘要翻译： 本发明涉及气体测量领域，更具体地涉及用于气体测量的测量装置（7）的测量功能的测试领域，测量装置（7）包括气体传感器（9），其产生至少一个输出 信号。 该方法包括将至少一个模拟信号连接到测量装置（7）和/或将气体混合物馈送到测量装置，其中在气体混合物中待测量的气体的浓度的大小是已知的。 本发明还涉及一种用于在测量测量装置（7）的测量功能时连接到用于气体测量的测量装置（7）的模拟装置（1）。 模拟装置（1）产生至少一个能够获得至少一个信号电平的模拟信号，其中某个信号值对应于一定的气体浓度。

公开(公告)号：US08181503B2

公开(公告)日：2012-05-22

申请号：US12421094

申请日：2009-04-09

申请人： Bryan Flaherty ,  Bhairavi Parikh ,  Kevin Nason ,  David Chazan ,  Jonathan Fay ,  John Kaiser ,  James Stone

发明人： Bryan Flaherty ,  Bhairavi Parikh ,  Kevin Nason ,  David Chazan ,  Jonathan Fay ,  John Kaiser ,  James Stone

IPC分类号： G01N33/497

CPC分类号： G01N33/497 ,  A61B5/097 ,  G01N21/783

摘要： The present invention is a disposable sensor for use with a device that quantifies analytes in a gaseous sample. It comprises (i) a sensing element, (ii) a means for interfacing the disposable sensor with a gas analysis device, and (iii) a housing. When used with a device that can quantify the concentration of an analyte in a gas sample, the present invention facilitates the use of exhaled breath analysis as a clinical tool.

摘要翻译： 本发明是用于量化气态样品中分析物的装置的一次性传感器。 它包括（i）感测元件，（ii）用于将一次性传感器与气体分析装置连接的装置，以及（iii）壳体。 当与可以量化气体样品中分析物的浓度的装置一起使用时，本发明有助于使用呼气分析作为临床工具。

公开(公告)号：US20110314896A1

公开(公告)日：2011-12-29

申请号：US12808672

申请日：2008-12-01

申请人： Mats Carlson ,  Tryggve Hemmingsson

发明人： Mats Carlson ,  Tryggve Hemmingsson

IPC分类号： G01N33/497

CPC分类号： A61B5/091 ,  A61B5/411

摘要： The function of a measuring device can be tested using a healthy person as an external control, provided that this person fulfils certain criteria and that particular method steps are adhered to.

摘要翻译： 测量装置的功能可以使用健康人作为外部控制进行测试，只要该人符合某些标准，并遵守特定的方法步骤。

公开(公告)号：US20080023078A1

公开(公告)日：2008-01-31

申请号：US11632253

申请日：2006-01-24

申请人： Svante Bahrton

发明人： Svante Bahrton

IPC分类号： F16K17/34

CPC分类号： F16K17/34 ,  F15C3/04 ,  F16K31/385 ,  G05D7/0113 ,  Y10T137/0396 ,  Y10T137/7754 ,  Y10T137/8593

摘要： A constant flow regulator device for maintaining a constant flow of fluid when a variable fluid pressure is applied, comprising an inlet duct (506) for incoming fluid, a housing (500), and a movable partition (502) facing the inlet duct and being subjected to an elastic force. A fluid passage (510) of variable cross section area is formed between the inlet duct and the movable partition. The housing and movable partition form an inner compartment (504) in fluid communication with the inlet duct for establishing a fluid pressure inside the inner compartment approximately equal to the fluid pressure in the inlet duct. The size of the movable partition is significantly greater than the size of the inlet duct such that, in use, the partition is moved towards the inlet duct against the elastic force when the fluid pressure in the inlet duct increases to reduce said fluid passage cross section area, and vice versa, thereby maintaining constant fluid flow.

摘要翻译： 一种用于在施加可变流体压力时保持流体恒定流量的恒定流量调节器装置，包括用于输入流体的入口管道（506），壳体（500）和面向入口管道的可移动分隔件（502） 受到弹力。 在入口管道和可移动隔板之间形成有可变横截面积的流体通道（510）。 壳体和可移动隔板形成与入口管道流体连通的内部隔室（504），用于在内部隔室内建立大致等于入口管道中的流体压力的流体压力。 可移动隔板的尺寸明显大于入口管道的尺寸，使得在使用中，当入口管道中的流体压力增加时，分隔件抵抗弹性力朝向入口管道移动，以减少所述流体通道横截面 面积，反之亦然，从而保持恒定的流体流动。

公开(公告)号：US20050143673A1

公开(公告)日：2005-06-30

申请号：US10496897

申请日：2003-01-31

申请人： Jon Lundberg ,  Eddie Weitzberg

发明人： Jon Lundberg ,  Eddie Weitzberg

IPC分类号： A61B10/00 ,  A61B5/08 ,  A61B5/083 ,  A61B5/085 ,  A61B5/087 ,  A61B7/00 ,  G01N1/22 ,  G01N31/00 ,  G01N33/497

CPC分类号： A61B5/411 ,  A61B5/08 ,  A61B5/082 ,  A61B5/085 ,  A61B7/003

摘要： It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.

摘要翻译： 惊奇地发现，通过在健康受试者中存在振荡气流，鼻NO释放被大大增加。 因此，包括用于产生和/或维持振荡气流的装置的装置被描述和建议用于诊断人的上呼吸道的状况。 本发明还包括其中在存在和不存在作用在上呼吸道或其部分上的振荡气流的情况下确定和记录在鼻呼出空气中的至少一种气体组分的浓度和/或流量的方法。

公开(公告)号：US6099480A

公开(公告)日：2000-08-08

申请号：US125872

申请日：1999-05-14

申请人： Lars Erik Gustafsson

发明人： Lars Erik Gustafsson

IPC分类号： A61B5/08 ,  A61B5/083 ,  A61B5/097 ,  G01N1/00 ,  G01N1/02 ,  G01N21/76 ,  G01N33/00 ,  G01N33/497

CPC分类号： G01N33/0037 ,  G01N21/76 ,  G01N33/497

摘要： The present invention relates to apparatus for determining a relevant proportion (a) of a chosen gas, an NO-gas or NO.sub.2 -gas, present in a gas mixture (A), such as in a gas mixture deriving from the expiration air or inspiration air of a living being (1), wherein an adapted sample proportion of the breathing air is passed from an outlet (11) in the immediate vicinity of said being, via a hose (10') or the like, to measuring equipment (13') that includes a measuring chamber (14') that is placed under a subpressure and to which ozone gas is also supplied, wherewith the nitrogen oxide present reacts with the ozone-gas to form NO.sub.2 and light, and wherein the apparatus includes a light measuring unit (13') which is adapted to evaluate the light thus generated and to calculate (18) the amount of predominant gas in the breathing air on the basis of this evaluation. The volume (14b') of the measuring chamber of such apparatus is adapted to include the volume enclosed in the hose (10') used. The hose-related valve (11a') or constriction that delimits the subpressure volume of the measuring chamber is provided in the close proximity of the being (1). A means (30) for reducing the water vapour in the breathing air sample (A), e.g. by cooling and/or freezing, is adapted upstream of the measuring chamber (14') to reduce or eliminate precipitation of water in the measuring chamber.

摘要翻译： PCT No.PCT / SE97 / 00159 Sec。 371日期1999年5月14日 102（e）日期1999年5月14日PCT提交1997年2月1日PCT公布。 出版物WO97 / 32210 日期1997年9月4日本发明涉及用于确定气体混合物（A）中存在的选定气体，NO气体或NO 2气体的相关比例（a）的装置，例如来自 活体（1）的呼气或呼吸空气，其中呼吸空气的适应样品比例通过软管（10'）等从所述出口（11）通过， 包括设置在副压力下并且还供应臭氧气体的测量室（14'）的测量设备（13'），其中存在的氮氧化物与臭氧气体反应以形成NO 2和光，并且其中 所述装置包括光测量单元（13'），其适于评估由此产生的光，并且基于该评估计算（18）呼吸空气中的主要气体的量。 这种装置的测量室的体积（14b'）适于包括封闭在所使用的软管（10'）中的体积。 在与（1）的非常接近的地方设置限定测量室的负压容积的软管相关阀（11a'）或缩颈。 一种用于减少呼吸空气样品（A）中的水蒸气的装置（30），例如， 通过冷却和/或冷冻来适应测量室（14'）的上游，以减少或消除测量室中的水的沉淀。

公开(公告)号：US09931057B2

公开(公告)日：2018-04-03

申请号：US13989491

申请日：2011-12-07

申请人： Rudiger Eichler

发明人： Rudiger Eichler

IPC分类号： A61B5/08 ,  A61B5/097 ,  G01N33/497 ,  A61B5/113 ,  A61B5/00

摘要： An apparatus for the collection of samples of exhaled air during normal respiration, comprising a flow generator, an orally insertable exhalation air receiver, and a device for isolating the nasal airways, wherein the apparatus further comprises: a sensor for detecting a change in a parameter representing the change from inhalation to exhalation and to transmit said change as a signal; a control unit adapted to receive said signal and to control said device for isolating the nasal airways; wherein the flow generator is connected to or integrated with the exhalation air receiver. A method of collecting samples of exhaled air during normal respiration conditions, comprising the steps of: detecting a change in a parameter representing the change from inhalation to exhalation and transmitting said change as a signal; receiving said signal in a control unit; activating a device for isolating the nasal airways; activating a flow generator connected to an exhalation air receiver; and collecting a sample of exhaled air during exhalation when the nasal airways are isolated.