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公开(公告)号：US20100092441A1
公开(公告)日：2010-04-15
申请号：US12528794
申请日：2008-02-26
申请人： Jon Lundberg , Eddie Weitzberg
发明人： Jon Lundberg , Eddie Weitzberg
CPC分类号： A61K31/05 , A23L33/16 , A61K31/21 , A61K33/00 , A61K36/185 , A61K36/21 , A61K36/28 , A61K2300/00
摘要： Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a drop in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.
摘要翻译： 无机阴离子硝酸盐和亚硝酸盐影响代谢速率和葡萄糖体内平衡。 亚硝酸盐的输入iv导致休息能量消耗（耗氧量）和硝酸盐的急剧下降，当口服给药时，导致运动中氧消耗下降，口服葡萄糖耐量试验后观察到的血糖增加减少。 硝酸盐和亚硝酸盐的剂量不会引起血红蛋白水平的任何可检测的变化。 硝酸盐和亚硝酸盐也不会改变血液中的乳酸水平。 该发现提供了通过施用无机亚硝酸盐和/或硝酸盐来调节哺乳动物的能量消耗和葡萄糖体内平衡的有用治疗方法。
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公开(公告)号：US07270638B2
公开(公告)日：2007-09-18
申请号：US10496897
申请日：2003-01-31
申请人： Jon Lundberg , Eddie Weitzberg
发明人： Jon Lundberg , Eddie Weitzberg
IPC分类号： A61B5/08
摘要： It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.
摘要翻译： 惊奇地发现，通过在健康受试者中存在振荡气流，鼻NO释放被大大增加。 因此，包括用于产生和/或维持振荡气流的装置的装置被描述和建议用于诊断人的上呼吸道的状况。 本发明还包括其中在存在和不存在作用在上呼吸道或其部分上的振荡气流的情况下确定和记录在鼻呼出空气中的至少一种气体组分的浓度和/或流量的方法。
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公开(公告)号：US06308703B1
公开(公告)日：2001-10-30
申请号：US09292598
申请日：1999-04-16
申请人： Kjell Alving , Jan M. Lundberg , Jon Lundberg , Eddie Weitzberg
发明人： Kjell Alving , Jan M. Lundberg , Jon Lundberg , Eddie Weitzberg
IPC分类号： A61M1500
CPC分类号： A61M16/0045 , A61M16/00 , A61M16/04 , A61M16/0666 , A61M2202/0275 , A61M2202/203 , A61M2202/206
摘要： The present invention restores the normal low-dose flushing of the lower airways with air from the upper airways, containing nitric oxide (NO) and possible other biologically active agents by aspiration of air from the upper airways and introducing said air in the inspiratory airflow of a ventilator. The inventive apparatus and method is free from the risks associated with traditional administration of exogenous NO.
摘要翻译： 本发明通过从上呼吸道吸入空气从上呼吸道的空气中回收含有一氧化氮（NO）和可能的其它生物活性剂的下气道的正常低剂量冲洗，并将所述空气在吸气气流中引入 一个呼吸机 本发明的装置和方法没有与传统给药外源NO相关的风险。
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4.发明授权Method and device for use in the diagnosis of inflammatory states in the urogenital tract 失效用于诊断泌尿生殖道炎症状态的方法和装置
公开(公告)号：US6149606A
公开(公告)日：2000-11-21
申请号：US156000
申请日：1998-12-08
申请人： Kjell Alving , Jan M. Lundberg , Jon Lundberg , Eddie Weitzberg , Peter Wiklund
发明人： Kjell Alving , Jan M. Lundberg , Jon Lundberg , Eddie Weitzberg , Peter Wiklund
IPC分类号： A61B10/00 , A61B5/00 , G01N33/497
CPC分类号： A61B5/145 , A61B5/411 , G01N33/497
摘要： Device and method for collecting endogenous gaseous nitric oxide (NO), in the urogenital tract, for example in the urinary tract and in the uterus and oviducts. According to one embodiment, a NO permeable, liquid impermeable inflatable body (16) is positioned in the urethra (5) surrounded by the prostate gland (17), whereby an additional inflatable body (4) positioned in the bladder (2) serves to seal off the bladder from the urethra and helps in the positioning of the device. The present invention further relates to a method and a system for use in the diagnosis of inflammatory states in said organs.
摘要翻译： PCT No.PCT / SE97 / 00610 Sec。 371日期1998年12月8日第 102（e）日期1998年12月8日PCT 1997年4月11日PCT PCT。 公开号WO97 / 37587 日期1997年10月16日在泌尿生殖道中，例如在尿道和子宫和输卵管中收集内源性一氧化氮（NO）的装置和方法。 根据一个实施例，NO渗透的液体不可渗透的可充气体（16）定位在由前列腺（17）包围的尿道（5）中，由此定位在囊（2）中的另外的可充气体（4）用于 从尿道密封膀胱，有助于设备的定位。 本发明还涉及用于诊断所述器官中炎性状态的方法和系统。
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公开(公告)号：US09180140B2
公开(公告)日：2015-11-10
申请号：US12528798
申请日：2008-02-26
申请人： Jon Lundberg , Eddie Weitzberg
发明人： Jon Lundberg , Eddie Weitzberg
CPC分类号： A61K33/00 , A23L2/52 , A23L33/105 , A23L33/135 , A23L33/16 , A23V2002/00 , A61K9/0056 , A61K31/375 , A61K36/185 , A61K36/21 , A61K45/06 , C01D9/00 , A61K2300/00 , A23V2200/33 , A23V2250/15
摘要： The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.
摘要翻译： 可以通过向所述哺乳动物施用无毒量的硝酸盐和/或亚硝酸盐来增强体育运动期间表现为氧吸收降低（VO2）的哺乳动物的表现。 提供液体，半固体和固体小吃，食品和营养补充剂，如运动饮料。
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公开(公告)号：US20050143673A1
公开(公告)日：2005-06-30
申请号：US10496897
申请日：2003-01-31
申请人： Jon Lundberg , Eddie Weitzberg
发明人： Jon Lundberg , Eddie Weitzberg
IPC分类号： A61B10/00 , A61B5/08 , A61B5/083 , A61B5/085 , A61B5/087 , A61B7/00 , G01N1/22 , G01N31/00 , G01N33/497
摘要： It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.
摘要翻译： 惊奇地发现，通过在健康受试者中存在振荡气流，鼻NO释放被大大增加。 因此，包括用于产生和/或维持振荡气流的装置的装置被描述和建议用于诊断人的上呼吸道的状况。 本发明还包括其中在存在和不存在作用在上呼吸道或其部分上的振荡气流的情况下确定和记录在鼻呼出空气中的至少一种气体组分的浓度和/或流量的方法。
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公开(公告)号：US20070239107A1
公开(公告)日：2007-10-11
申请号：US10583113
申请日：2004-12-15
申请人： Jon Lundberg , Eddie Weitzberg
发明人： Jon Lundberg , Eddie Weitzberg
IPC分类号： A61M29/00
CPC分类号： A61M31/00 , A61J15/0015 , A61J15/0042 , A61M25/10
摘要： The present invention discloses a device and a method for reducing the risk of hospital-acquired infections, nocosomial infections, originating from the insertion of the device and/or use of the device in the body of a human or animal. The invention in particular relates to a device releasing at least one low molecular antimicrobial compound permeating the device thereby exerting its antimicrobial effect also on the outside of the device.
摘要翻译： 本发明公开了一种用于降低医院获得性感染的风险的装置和方法，其来源于该装置的插入和/或将该装置用于人体或动物体内。 本发明特别涉及一种释放至少一种渗透该装置的低分子抗微生物化合物的装置，从而也在该装置的外部施加其抗微生物作用。
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公开(公告)号：US06723056B1
公开(公告)日：2004-04-20
申请号：US09688860
申请日：2000-10-17
IPC分类号： A61B500
CPC分类号： A61B5/411 , A61B5/097 , G01N33/497
摘要： A gas sample containing an inorganic constituent, such as a sample of exhaled air is collected in a bag (b 1) comprising an inlet/outlet (2) and a reagent chamber (3) which makes possible the storage and transport of said sample and thus enables efficient and repeatable off-line determinations of inorganic components in said sample. A sample collection device, a system comprising said device and a method of its use is disclosed.
摘要翻译： 含有无机成分（如呼出空气样品）的气体样品被收集在包括入口/出口（2）和试剂室（3）的袋子（b 1）中，所述袋子（2）和试剂室（3）使得所述样品的储存和运输成为可能， 从而能够对所述样品中的无机组分进行有效和可重复的离线测定。 公开了一种样品收集装置，包括所述装置的系统及其使用方法。
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公开(公告)号：US06183416B2
公开(公告)日：2001-02-06
申请号：US09273514
申请日：1999-03-22
申请人： Kjell Alving , Jan M. Lundberg , Jon Lundberg , Eddie Weitzberg
发明人： Kjell Alving , Jan M. Lundberg , Jon Lundberg , Eddie Weitzberg
IPC分类号： A61B500
CPC分类号： A61B10/00 , A61B2010/0083 , G01N33/497 , Y10T436/173076
摘要： Method for diagnosis of inflammatory conditions in the intestinal canal of humans, characterized in that NO is measured in the lumen of the intestines. The NO level obtained is then compared with the level obtained for healthy individuals or with the level obtained for the same individual at another occasion. An increased level compared to the normal levels in the intestines of the healthy population is an indication of an inflammatory condition in the intestine.
摘要翻译： 用于诊断人体肠道炎症状况的方法，其特征在于在肠腔内测量NO。 然后将获得的NO水平与对于健康个体获得的水平或在另一时间为相同个体获得的水平进行比较。 与健康人群的肠道正常水平相比，增加了肠道炎症状态。
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公开(公告)号：US20100047344A1
公开(公告)日：2010-02-25
申请号：US12528798
申请日：2008-02-26
申请人： Jon Lundberg , Eddie Weitzberg
发明人： Jon Lundberg , Eddie Weitzberg
CPC分类号： A61K33/00 , A23L2/52 , A23L33/105 , A23L33/135 , A23L33/16 , A23V2002/00 , A61K9/0056 , A61K31/375 , A61K36/185 , A61K36/21 , A61K45/06 , C01D9/00 , A61K2300/00 , A23V2200/33 , A23V2250/15
摘要： The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.
摘要翻译： 可以通过向所述哺乳动物施用无毒量的硝酸盐和/或亚硝酸盐来增强体育运动期间表现为氧吸收降低（VO2）的哺乳动物的表现。 提供液体，半固体和固体小吃，食品和营养补充剂，如运动饮料。
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