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    USE OF NITRITES AND NITRATES AND COMPOSITIONS CONTAINING THESE
    1.
    发明申请
    USE OF NITRITES AND NITRATES AND COMPOSITIONS CONTAINING THESE 审中-公开
    使用硝酸盐和硝酸盐及其组合物

    公开(公告)号：US20100092441A1

    公开(公告)日：2010-04-15

    申请号：US12528794

    申请日：2008-02-26

    申请人： Jon Lundberg ,  Eddie Weitzberg

    发明人： Jon Lundberg ,  Eddie Weitzberg

    IPC分类号： A61K33/00 ,  C01B21/20 ,  A61K35/74 ,  A61P3/00

    CPC分类号： A61K31/05 ,  A23L33/16 ,  A61K31/21 ,  A61K33/00 ,  A61K36/185 ,  A61K36/21 ,  A61K36/28 ,  A61K2300/00

    摘要： Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a drop in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.

    摘要翻译： 无机阴离子硝酸盐和亚硝酸盐影响代谢速率和葡萄糖体内平衡。 亚硝酸盐的输入iv导致休息能量消耗（耗氧量）和硝酸盐的急剧下降，当口服给药时，导致运动中氧消耗下降，口服葡萄糖耐量试验后观察到的血糖增加减少。 硝酸盐和亚硝酸盐的剂量不会引起血红蛋白水平的任何可检测的变化。 硝酸盐和亚硝酸盐也不会改变血液中的乳酸水平。 该发现提供了通过施用无机亚硝酸盐和/或硝酸盐来调节哺乳动物的能量消耗和葡萄糖体内平衡的有用治疗方法。

    Method and device for diagnosis using an oscillating airflow
    2.
    发明授权
    Method and device for diagnosis using an oscillating airflow 有权
    使用振荡气流进行诊断的方法和装置

    公开(公告)号：US07270638B2

    公开(公告)日：2007-09-18

    申请号：US10496897

    申请日：2003-01-31

    申请人： Jon Lundberg ,  Eddie Weitzberg

    发明人： Jon Lundberg ,  Eddie Weitzberg

    IPC分类号： A61B5/08

    CPC分类号： A61B5/411 ,  A61B5/08 ,  A61B5/082 ,  A61B5/085 ,  A61B7/003

    摘要： It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.

    摘要翻译： 惊奇地发现，通过在健康受试者中存在振荡气流，鼻NO释放被大大增加。 因此，包括用于产生和/或维持振荡气流的装置的装置被描述和建议用于诊断人的上呼吸道的状况。 本发明还包括其中在存在和不存在作用在上呼吸道或其部分上的振荡气流的情况下确定和记录在鼻呼出空气中的至少一种气体组分的浓度和/或流量的方法。

    Ventilator device
    3.
    发明授权
    Ventilator device 失效
    呼吸机装置

    公开(公告)号：US06308703B1

    公开(公告)日：2001-10-30

    申请号：US09292598

    申请日：1999-04-16

    申请人： Kjell Alving ,  Jan M. Lundberg ,  Jon Lundberg ,  Eddie Weitzberg

    发明人： Kjell Alving ,  Jan M. Lundberg ,  Jon Lundberg ,  Eddie Weitzberg

    IPC分类号： A61M1500

    CPC分类号： A61M16/0045 ,  A61M16/00 ,  A61M16/04 ,  A61M16/0666 ,  A61M2202/0275 ,  A61M2202/203 ,  A61M2202/206

    摘要： The present invention restores the normal low-dose flushing of the lower airways with air from the upper airways, containing nitric oxide (NO) and possible other biologically active agents by aspiration of air from the upper airways and introducing said air in the inspiratory airflow of a ventilator. The inventive apparatus and method is free from the risks associated with traditional administration of exogenous NO.

    摘要翻译： 本发明通过从上呼吸道吸入空气从上呼吸道的空气中回收含有一氧化氮（NO）和可能的其它生物活性剂的下气道的正常低剂量冲洗，并将所述空气在吸气气流中引入 一个呼吸机 本发明的装置和方法没有与传统给药外源NO相关的风险。

    Method and device for use in the diagnosis of inflammatory states in the urogenital tract
    4.
    发明授权
    Method and device for use in the diagnosis of inflammatory states in the urogenital tract 失效
    用于诊断泌尿生殖道炎症状态的方法和装置

    公开(公告)号：US6149606A

    公开(公告)日：2000-11-21

    申请号：US156000

    申请日：1998-12-08

    申请人： Kjell Alving ,  Jan M. Lundberg ,  Jon Lundberg ,  Eddie Weitzberg ,  Peter Wiklund

    发明人： Kjell Alving ,  Jan M. Lundberg ,  Jon Lundberg ,  Eddie Weitzberg ,  Peter Wiklund

    IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/497

    CPC分类号： A61B5/145 ,  A61B5/411 ,  G01N33/497

    摘要： Device and method for collecting endogenous gaseous nitric oxide (NO), in the urogenital tract, for example in the urinary tract and in the uterus and oviducts. According to one embodiment, a NO permeable, liquid impermeable inflatable body (16) is positioned in the urethra (5) surrounded by the prostate gland (17), whereby an additional inflatable body (4) positioned in the bladder (2) serves to seal off the bladder from the urethra and helps in the positioning of the device. The present invention further relates to a method and a system for use in the diagnosis of inflammatory states in said organs.

    摘要翻译： PCT No.PCT / SE97 / 00610 Sec。 371日期1998年12月8日第 102（e）日期1998年12月8日PCT 1997年4月11日PCT PCT。 公开号WO97 / 37587 日期1997年10月16日在泌尿生殖道中，例如在尿道和子宫和输卵管中收集内源性一氧化氮（NO）的装置和方法。 根据一个实施例，NO渗透的液体不可渗透的可充气体（16）定位在由前列腺（17）包围的尿道（5）中，由此定位在囊（2）中的另外的可充气体（4）用于 从尿道密封膀胱，有助于设备的定位。 本发明还涉及用于诊断所述器官中炎性状态的方法和系统。

    Method and composition for inhibition of nitric oxide production in the oral cavity
    6.
    发明授权
    Method and composition for inhibition of nitric oxide production in the oral cavity 有权
    抑制口腔一氧化氮生成的方法和组成

    公开(公告)号：US06626844B1

    公开(公告)日：2003-09-30

    申请号：US09601289

    申请日：2000-09-01

    申请人： Kjell Alving ,  Jon Lundberg

    发明人： Kjell Alving ,  Jon Lundberg

    IPC分类号： A61B500

    CPC分类号： G01N33/497

    摘要： The disturbing influence or orally produced nitric oxide in the measuring of exhaled nitric oxide can be ameliorated or totally eliminated through the use of a method and composition according to the present invention. The production of NO in the oral cavity is temporarily inhibited by the application of a composition having anti-bacterial and/or pH increasing effect.

    摘要翻译： 通过使用根据本发明的方法和组合物可以改善或完全消除呼出一氧化氮测量中的干扰影响或口服产生的一氧化氮。 通过施用具有抗菌和/或pH增加效果的组合物，临时抑制口腔内产生NO。

    Method and device for diagnosis using an oscillating airflow
    9.
    发明申请
    Method and device for diagnosis using an oscillating airflow 有权
    使用振荡气流进行诊断的方法和装置

    公开(公告)号：US20050143673A1

    公开(公告)日：2005-06-30

    申请号：US10496897

    申请日：2003-01-31

    申请人： Jon Lundberg ,  Eddie Weitzberg

    发明人： Jon Lundberg ,  Eddie Weitzberg

    IPC分类号： A61B10/00 ,  A61B5/08 ,  A61B5/083 ,  A61B5/085 ,  A61B5/087 ,  A61B7/00 ,  G01N1/22 ,  G01N31/00 ,  G01N33/497

    CPC分类号： A61B5/411 ,  A61B5/08 ,  A61B5/082 ,  A61B5/085 ,  A61B7/003

    摘要： It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.

    摘要翻译： 惊奇地发现，通过在健康受试者中存在振荡气流，鼻NO释放被大大增加。 因此，包括用于产生和/或维持振荡气流的装置的装置被描述和建议用于诊断人的上呼吸道的状况。 本发明还包括其中在存在和不存在作用在上呼吸道或其部分上的振荡气流的情况下确定和记录在鼻呼出空气中的至少一种气体组分的浓度和/或流量的方法。

    Use of nitrites and nitrates and compositions containing these
    10.
    发明授权
    Use of nitrites and nitrates and compositions containing these 有权

    公开(公告)号：US10406118B2

    公开(公告)日：2019-09-10

    申请号：US12528794

    申请日：2008-02-26

    申请人： Jon Lundberg ,  Eddie Weitzberg

    发明人： Jon Lundberg ,  Eddie Weitzberg

    IPC分类号： A23L33/16 ,  A61K31/05 ,  A61K33/00 ,  A61K31/21 ,  A61K36/21 ,  A61K36/28 ,  A61K36/185

    摘要： Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a drop in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.