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公开(公告)号:US11123433B2
公开(公告)日:2021-09-21
申请号:US16306429
申请日:2017-02-07
申请人: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人: Donghui Zhang , Vijay John , Yueheng Zhang , Sunting Xuan
摘要: A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery.
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公开(公告)号:US11106980B2
公开(公告)日:2021-08-31
申请号:US16759595
申请日:2018-10-25
发明人: Eliot Kapit
摘要: Embodiments herein implement quantum annealing with a driver Hamiltonian that uses oscillating fields to advantageously obtain a quantum speedup over classical computing techniques. For a many-body quantum system formed with qubits, the oscillating fields drive the qubits so as to independently modulate the magnitudes and/or directions of transverse terms of the driver Hamiltonian. In particular, embodiments provide a quantum speedup for two types of first-order phase transitions: the paramagnet-to-spin-glass transition, and transitions between distinct “bit string” states. The resulting speedup is robust against energy fluctuations (e.g., 1/f noise), in contrast to other strategies like variable-rate annealing. Each oscillating field may be an oscillating electric field or magnetic field. The oscillating fields can be implemented with superconducting flux qubits by coupling oscillating fluxes and/or voltages to the flux qubits.
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公开(公告)号:US11029303B2
公开(公告)日:2021-06-08
申请号:US15827241
申请日:2017-11-30
发明人: Diane Blake , Yue Sun
摘要: The invention is directed to antibody compositions that specifically bind to polycyclic aromatic hydrocarbons (PAHs) and kits encompassing the same.
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公开(公告)号:US20210162033A1
公开(公告)日:2021-06-03
申请号:US17046723
申请日:2019-04-10
摘要: Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be 5 used as adjuvants in compositions and methods to potentiate the immune response to immunogens.
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公开(公告)号:US20210109083A1
公开(公告)日:2021-04-15
申请号:US17081213
申请日:2020-10-27
发明人: Damir Khismatullin , Daishen Luo
摘要: The disclosed apparatus, systems and methods relate to ATPA technology that provides a method for the real-time assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device. The acoustic tweezing technology integrates photo-optical tests used in plasma coagulation assays with mechanical (viscoelastic) tests used in whole blood analysis. Its key disruptive features are the increased reliability and accuracy due to non-contact measurement, low sample volume requirement, relatively short procedure time (less than 10 minutes), and the ability to assess the level of Factor XIII function from measurements of the fibrin network formation time.
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16.
公开(公告)号:US10953081B2
公开(公告)日:2021-03-23
申请号:US16591599
申请日:2019-10-02
IPC分类号: A61K39/00 , A61K39/104 , A61K39/108 , A61K9/00
摘要: The invention provides methods and compositions for preventing or ameliorating pulmonary infections with Pseudomonas aeruginosa.
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公开(公告)号:US10537634B2
公开(公告)日:2020-01-21
申请号:US16176743
申请日:2018-10-31
IPC分类号: A61K39/395 , C07K17/02 , C07K16/10 , A61K39/12 , C07K14/005 , A61K39/00
摘要: Immunogenic influenza hemagglutinin-derived peptide compositions described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide compositions comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein bound to an immunogenic carrier protein, such as an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide compositions described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections.
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公开(公告)号:US10400237B2
公开(公告)日:2019-09-03
申请号:US15448225
申请日:2017-03-02
发明人: Shusheng Wang , Qinbo Zhou
IPC分类号: A61K31/713 , C12N15/113 , A61K45/06 , C12N5/00
摘要: The present disclosure provides compositions and methods of their use to impair angiogenesis in a patient to treat indications including, but not limited to, tumor growth, age-related macular degeneration, and metastasis. Also provided are compositions and methods for promoting angiogenesis in patients in need thereof.
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公开(公告)号:US20190115869A1
公开(公告)日:2019-04-18
申请号:US16089294
申请日:2017-03-28
发明人: Matthew David Escarra , Qi Xy , Yaping Ji , Brian C. Riggs , Adam Ollanik , Kazi M. Islam , Daniel Codd , Vince Romanin , Nicholas David Farrar-Foley
IPC分类号: H02S40/42 , H01L31/052 , H02S40/22 , H02S20/32 , H01L31/048 , H02S40/44 , H01L31/0687
摘要: A spectrum splitting, transmissive concentrating photovoltaic (tCPV) module is proposed and designed for a hybrid photovoltaic-solar thermal (PV/T) system. The system may be able to fully utilize the full spectrum of incoming sunlight. By utilizing III-V triple junction solar cells with bandgaps of approximately 2.1 eV, 1.7 eV, and 1.4 eV in the module, ultraviolet (UV) and visible light (in-band light) are absorbed and converted to electricity, while infrared (IR) light (out-of-band light) passes through and is captured by a solar thermal receiver and stored as heat. The stored heat energy may be dispatched as electricity or process heat as needed. The tCPV module may have an overall power conversion efficiency exceeding 43.5% for above bandgap (in-band) light under a standard AM1.5D solar spectrum with an average concentration ratio of 400 suns. Passive and/or active cooling methods may be used to keep cells below 110° C. while transmitting >75% of out-of-band light to the thermal receiver, which may attain thermal energy capture at temperatures as high as 500° C. or more. A transparent active cooling system may improve the CPV module efficiency by about 1% (absolute) relative to a passive cooling system by reducing the maximum cell working temperature by about 16° C.
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20.
公开(公告)号:US10259975B2
公开(公告)日:2019-04-16
申请号:US15366444
申请日:2016-12-01
发明人: Noshir Pesika , Kejia Jin
IPC分类号: C09J9/00 , C09J7/00 , C09J183/04 , B82Y30/00 , B81C1/00 , C09J175/04 , F16B5/07 , F16B11/00
摘要: The present invention relates to an easy, scalable method, relying on conventional and unconventional techniques, to incorporate tilt in the fabrication of synthetic polymer-based dry adhesives mimicking the gecko adhesive system. These dry, reversible adhesives demonstrate anisotropic adhesion properties, providing strong adhesion and friction forces when actuated in the gripping direction and an initial repulsive normal force and negligible friction when actuated in the releasing direction.
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