Abstract:
This invention relates to compounds which are agonists of the progesterone receptor which have the general structure: wherein: R1, R2, R3, R4, R5 and Q1 are as defined herein, or a pharmaceutically acceptable salt thereof, as well as methods of using these compounds to induce contraception or treat progesterone-related carcinomas and adenocarcinomas.
Abstract translation:本发明涉及作为孕酮受体激动剂的化合物,其具有以下通式结构:其中:R 1,R 2,R 3, R 4,R 5和Q 1如本文所定义,或其药学上可接受的盐,以及使用这些化合物的方法 诱导避孕或治疗孕激素相关的癌和腺癌。
Abstract:
A chain tensioner has a spring-biased plunger with rack teeth engageable with teeth of wedge-shaped cam chips cooperating with a spring-biased cam-receiving ring in a recess formed in a tensioner housing. A seal plate, having a central hole through which the plunger extends, is provided as a closure for the recess to hold the cam chip assembly in place. A wire loop, for temporarily engaging a pin protruding laterally from the plunger, is pivoted in tube formed by rolling a portion of a seal plate. The wire loop holds the plunger in its retracted state while the tensioner is being installed, and automatically disengages the laterally protruding pin when the plunger is pushed inward by a tensioner lever, thereby releasing the plunger for normal operation.
Abstract:
A waste carbonizing and energy utilizing system comprises a carbonizer, a gasifying fusion furnace, and a power generation plant for utilizing heat energy. The carbonizer 20 carbonizes waste to generate charcoal. The gasifying fusion furnace incinerates the charcoal, and then the heat generated by the incineration of the charcoal is used for operation of the power generation plant. Exhaust heat from the power generation plant is recycled to the carbonizer.
Abstract:
A wetsuit is composed multiple panels sewn together in edge-to-edge relationship, each panel comprising a highly stretchable base fabric sandwiched between an outer and inner layer of synthetic rubber, the outer synthetic rubber layer is dense and tough, providing protection against damage by abrasion, while the inner synthetic rubber layer is thicker and less dense, providing the material with a good insulating ability. The outer layer is thinner than the inner layer to compensate for the higher elastic modulus of the denser outer layer, so that the layers stretch uniformly. A thin, colored, chloroprene adhesive coating is provided on the outside of the outer layer, and the outer layer is embossed with a mesh pattern. The seams are blind-stitched through the base fabric from the outside. Because the stretchable fabric is on the inside of the wetsuit material, the wetsuit dries rapidly.
Abstract:
The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating vaginal and skin atrophy.
Abstract:
Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R1-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X′-Y′-R2 SEQ ID NO: 1 or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti-bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.
Abstract:
Provided is a hafnium silicide target for forming a gate oxide film composed of HfSi0.82-0.98, wherein the oxygen content is 500 to 10000 ppm. Manufactured is a hafnium silicide target for forming a gate oxide film, wherein powder of the composition composed of HfSi0.82-0.98 is synthesized, pulverized to be 100 mesh or less, and thereafter subject to hot pressing or hot isostatic pressing (HIP) at 1700° C. to 2120° C. and 150 to 2000 kgf/cm2. Thereby obtained is a hafnium silicide target, and the manufacturing method thereof, suitable for forming a HfSiO film and HfSiON film that may be used as a high dielectric gate insulation film, superior in embrittlement resistance, having a low generation of particles, and which is not likely to cause ignition of sintering powder or explosion of powder dust during the manufacturing process thereof.
Abstract:
In laminated, resin-impregnated doctor blades for removing water from a grooved belt in the press part of a papermaking machine, fibers of the belt-contacting layer are oriented in the direction of travel of the belt. The doctor blade so constructed exhibits greater adhesion to the belt, an improved water-removal capability, and greater durability, when compared with a doctor blade having randomly oriented surface fibers.
Abstract:
A wear-resistant coating, capable of imparting excellent wear resistance to a silent chain, comprises a base coating consisting of a hard inorganic material having interspersed particles of a hard inorganic material different from the inorganic material of the base coating. A part of the interspersed particles is exposed on the surface of the coating. The coating has superior oil-retaining properties as a result of gaps formed at the interface between the particles and the base coating, and the superior oil-retaining properties contribute to the wear-resistance of the coating.